Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation

Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation

Non-alcoholic fatty liver (NAFLD) disease causes degeneration of the liver, affects about 25% of people globally, and has no approved treatment. Here, the authors show that the therapeutic siRNA-driven silencing of MCJ in the liver is an effective and safe treatment for NAFLD in multiple mouse model...

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Autores principales: Lucía Barbier-Torres, Karen A. Fortner, Paula Iruzubieta, Teresa C. Delgado, Emily Giddings, Youdinghuan Chen, Devin Champagne, David Fernández-Ramos, Daniela Mestre, Beatriz Gomez-Santos, Marta Varela-Rey, Virginia Gutiérrez de Juan, Pablo Fernández-Tussy, Imanol Zubiete-Franco, Carmelo García-Monzón, Águeda González-Rodríguez, Dhaval Oza, Felipe Valença-Pereira, Qian Fang, Javier Crespo, Patricia Aspichueta, Frederic Tremblay, Brock C. Christensen, Juan Anguita, María Luz Martínez-Chantar, Mercedes Rincón
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/f4585c15ec8641c2ad4a105f86c1a9ca
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spelling oai:doaj.org-article:f4585c15ec8641c2ad4a105f86c1a9ca2021-12-02T16:32:09ZSilencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation10.1038/s41467-020-16991-22041-1723https://doaj.org/article/f4585c15ec8641c2ad4a105f86c1a9ca2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16991-2https://doaj.org/toc/2041-1723Non-alcoholic fatty liver (NAFLD) disease causes degeneration of the liver, affects about 25% of people globally, and has no approved treatment. Here, the authors show that the therapeutic siRNA-driven silencing of MCJ in the liver is an effective and safe treatment for NAFLD in multiple mouse models.Lucía Barbier-TorresKaren A. FortnerPaula IruzubietaTeresa C. DelgadoEmily GiddingsYoudinghuan ChenDevin ChampagneDavid Fernández-RamosDaniela MestreBeatriz Gomez-SantosMarta Varela-ReyVirginia Gutiérrez de JuanPablo Fernández-TussyImanol Zubiete-FrancoCarmelo García-MonzónÁgueda González-RodríguezDhaval OzaFelipe Valença-PereiraQian FangJavier CrespoPatricia AspichuetaFrederic TremblayBrock C. ChristensenJuan AnguitaMaría Luz Martínez-ChantarMercedes RincónNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lucía Barbier-Torres
Karen A. Fortner
Paula Iruzubieta
Teresa C. Delgado
Emily Giddings
Youdinghuan Chen
Devin Champagne
David Fernández-Ramos
Daniela Mestre
Beatriz Gomez-Santos
Marta Varela-Rey
Virginia Gutiérrez de Juan
Pablo Fernández-Tussy
Imanol Zubiete-Franco
Carmelo García-Monzón
Águeda González-Rodríguez
Dhaval Oza
Felipe Valença-Pereira
Qian Fang
Javier Crespo
Patricia Aspichueta
Frederic Tremblay
Brock C. Christensen
Juan Anguita
María Luz Martínez-Chantar
Mercedes Rincón
Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation
description Non-alcoholic fatty liver (NAFLD) disease causes degeneration of the liver, affects about 25% of people globally, and has no approved treatment. Here, the authors show that the therapeutic siRNA-driven silencing of MCJ in the liver is an effective and safe treatment for NAFLD in multiple mouse models.
format article
author Lucía Barbier-Torres
Karen A. Fortner
Paula Iruzubieta
Teresa C. Delgado
Emily Giddings
Youdinghuan Chen
Devin Champagne
David Fernández-Ramos
Daniela Mestre
Beatriz Gomez-Santos
Marta Varela-Rey
Virginia Gutiérrez de Juan
Pablo Fernández-Tussy
Imanol Zubiete-Franco
Carmelo García-Monzón
Águeda González-Rodríguez
Dhaval Oza
Felipe Valença-Pereira
Qian Fang
Javier Crespo
Patricia Aspichueta
Frederic Tremblay
Brock C. Christensen
Juan Anguita
María Luz Martínez-Chantar
Mercedes Rincón
author_facet Lucía Barbier-Torres
Karen A. Fortner
Paula Iruzubieta
Teresa C. Delgado
Emily Giddings
Youdinghuan Chen
Devin Champagne
David Fernández-Ramos
Daniela Mestre
Beatriz Gomez-Santos
Marta Varela-Rey
Virginia Gutiérrez de Juan
Pablo Fernández-Tussy
Imanol Zubiete-Franco
Carmelo García-Monzón
Águeda González-Rodríguez
Dhaval Oza
Felipe Valença-Pereira
Qian Fang
Javier Crespo
Patricia Aspichueta
Frederic Tremblay
Brock C. Christensen
Juan Anguita
María Luz Martínez-Chantar
Mercedes Rincón
author_sort Lucía Barbier-Torres
title Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation
title_short Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation
title_full Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation
title_fullStr Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation
title_full_unstemmed Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation
title_sort silencing hepatic mcj attenuates non-alcoholic fatty liver disease (nafld) by increasing mitochondrial fatty acid oxidation
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/f4585c15ec8641c2ad4a105f86c1a9ca
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