Physical Properties of Shellac Material Used for Hot Melt Extrusion with Potential Application in the Pharmaceutical Industry

Hot melt extrusion offers an efficient way of increasing the solubility of a poorly soluble drug. Shellac has potential as a pharmaceutical matrix polymer that can be used in this extrusion process, with further advantages for use in enteric drug delivery systems. The rheological property of a mater...

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Autores principales:	Guangming Yan, Zhi Cao, Declan Devine, Manfred Penning, Noel M. Gately
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	shellac hot melt extrusion rheology solubility enhancement processability DSC Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/f45908b1b9b343ed839c52cc3976236a
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spelling	oai:doaj.org-article:f45908b1b9b343ed839c52cc3976236a2021-11-11T18:45:10ZPhysical Properties of Shellac Material Used for Hot Melt Extrusion with Potential Application in the Pharmaceutical Industry10.3390/polym132137232073-4360https://doaj.org/article/f45908b1b9b343ed839c52cc3976236a2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/21/3723https://doaj.org/toc/2073-4360Hot melt extrusion offers an efficient way of increasing the solubility of a poorly soluble drug. Shellac has potential as a pharmaceutical matrix polymer that can be used in this extrusion process, with further advantages for use in enteric drug delivery systems. The rheological property of a material affects the extrusion process conditions. However, the literature does not refer to any published work that investigates the processability of various shellac materials. This work explores various types of shellac and explores their physicochemical and thermal properties along with their processability in the hot melt extrusion application. Physicochemical characterization of the materials was achieved using differential scanning calorimetry, Fourier transform infrared spectroscopy, scanning electron microscopy and energy-dispersive X-ray spectroscopy. Additional processability characterization was achieved using melt flow index and rheology analysis. The results indicated that there was no chemical difference between the various shellac types compared in this study. However, the extrudable temperature ranges and rheological properties of different shellac types varied; SSB 55 Pharma FL had the lowest processing temperature and glass transition temperatures. Due to the shear-thinning behaviours, shellac can be extruded at lower temperatures. This study provides necessary data to determine the processing conditions in hot melt extrusion applications for the range of shellac materials.Guangming YanZhi CaoDeclan DevineManfred PenningNoel M. GatelyMDPI AGarticleshellachot melt extrusionrheologysolubility enhancementprocessabilityDSCOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3723, p 3723 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	shellac hot melt extrusion rheology solubility enhancement processability DSC Organic chemistry QD241-441
spellingShingle	shellac hot melt extrusion rheology solubility enhancement processability DSC Organic chemistry QD241-441 Guangming Yan Zhi Cao Declan Devine Manfred Penning Noel M. Gately Physical Properties of Shellac Material Used for Hot Melt Extrusion with Potential Application in the Pharmaceutical Industry
description	Hot melt extrusion offers an efficient way of increasing the solubility of a poorly soluble drug. Shellac has potential as a pharmaceutical matrix polymer that can be used in this extrusion process, with further advantages for use in enteric drug delivery systems. The rheological property of a material affects the extrusion process conditions. However, the literature does not refer to any published work that investigates the processability of various shellac materials. This work explores various types of shellac and explores their physicochemical and thermal properties along with their processability in the hot melt extrusion application. Physicochemical characterization of the materials was achieved using differential scanning calorimetry, Fourier transform infrared spectroscopy, scanning electron microscopy and energy-dispersive X-ray spectroscopy. Additional processability characterization was achieved using melt flow index and rheology analysis. The results indicated that there was no chemical difference between the various shellac types compared in this study. However, the extrudable temperature ranges and rheological properties of different shellac types varied; SSB 55 Pharma FL had the lowest processing temperature and glass transition temperatures. Due to the shear-thinning behaviours, shellac can be extruded at lower temperatures. This study provides necessary data to determine the processing conditions in hot melt extrusion applications for the range of shellac materials.
format	article
author	Guangming Yan Zhi Cao Declan Devine Manfred Penning Noel M. Gately
author_facet	Guangming Yan Zhi Cao Declan Devine Manfred Penning Noel M. Gately
author_sort	Guangming Yan
title	Physical Properties of Shellac Material Used for Hot Melt Extrusion with Potential Application in the Pharmaceutical Industry
title_short	Physical Properties of Shellac Material Used for Hot Melt Extrusion with Potential Application in the Pharmaceutical Industry
title_full	Physical Properties of Shellac Material Used for Hot Melt Extrusion with Potential Application in the Pharmaceutical Industry
title_fullStr	Physical Properties of Shellac Material Used for Hot Melt Extrusion with Potential Application in the Pharmaceutical Industry
title_full_unstemmed	Physical Properties of Shellac Material Used for Hot Melt Extrusion with Potential Application in the Pharmaceutical Industry
title_sort	physical properties of shellac material used for hot melt extrusion with potential application in the pharmaceutical industry
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f45908b1b9b343ed839c52cc3976236a
work_keys_str_mv	AT guangmingyan physicalpropertiesofshellacmaterialusedforhotmeltextrusionwithpotentialapplicationinthepharmaceuticalindustry AT zhicao physicalpropertiesofshellacmaterialusedforhotmeltextrusionwithpotentialapplicationinthepharmaceuticalindustry AT declandevine physicalpropertiesofshellacmaterialusedforhotmeltextrusionwithpotentialapplicationinthepharmaceuticalindustry AT manfredpenning physicalpropertiesofshellacmaterialusedforhotmeltextrusionwithpotentialapplicationinthepharmaceuticalindustry AT noelmgately physicalpropertiesofshellacmaterialusedforhotmeltextrusionwithpotentialapplicationinthepharmaceuticalindustry
_version_	1718431740510339072

Physical Properties of Shellac Material Used for Hot Melt Extrusion with Potential Application in the Pharmaceutical Industry

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