CD71+ erythroid suppressor cells impair adaptive immunity against Bordetella pertussis

Abstract Infant’s immune system cannot control infection or respond to vaccination as efficiently as older individuals, a phenomenon that has been attributed to immunological immaturity. Recently, we challenged this notion and proposed the presence of actively immunosuppressive and physiologically e...

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Autores principales:	Afshin Namdar, Petya Koleva, Shima Shahbaz, Stacy Strom, Volker Gerdts, Shokrollah Elahi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f45ac271bb1740f7b3de8106fa477fd5
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spelling	oai:doaj.org-article:f45ac271bb1740f7b3de8106fa477fd52021-12-02T15:06:14ZCD71+ erythroid suppressor cells impair adaptive immunity against Bordetella pertussis10.1038/s41598-017-07938-72045-2322https://doaj.org/article/f45ac271bb1740f7b3de8106fa477fd52017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07938-7https://doaj.org/toc/2045-2322Abstract Infant’s immune system cannot control infection or respond to vaccination as efficiently as older individuals, a phenomenon that has been attributed to immunological immaturity. Recently, we challenged this notion and proposed the presence of actively immunosuppressive and physiologically enriched CD71+ erythroid cells in neonates. Here we utilized Bordetella pertussis, a common neonatal respiratory tract pathogen, as a proof of concept to investigate the role of these cells in adaptive immunity. We observed that CD71+ cells have distinctive immunosuppressive properties and prevent recruitment of immune cells to the mucosal site of infection. CD71+ cells ablation unleashed induction of B. pertussis-specific protective cytokines (IL-17 and IFN-γ) in the lungs and spleen upon re-infection or vaccination. We also found that CD71+ cells suppress systemic and mucosal B. pertussis-specific antibody responses. Enhanced antigen-specific adaptive immunity following CD71+ cells depletion increased resistance of mice to B. pertussis infection. Furthermore, we found that human cord blood CD71+ cells also suppress T and B cell functions in vitro. Collectively, these data provide important insight into the role of CD71+ erythroid cells in adaptive immunity. We anticipate our results will spark renewed investigation in modulating the function of these cells to enhance host defense to infections in newborns.Afshin NamdarPetya KolevaShima ShahbazStacy StromVolker GerdtsShokrollah ElahiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Afshin Namdar Petya Koleva Shima Shahbaz Stacy Strom Volker Gerdts Shokrollah Elahi CD71+ erythroid suppressor cells impair adaptive immunity against Bordetella pertussis
description	Abstract Infant’s immune system cannot control infection or respond to vaccination as efficiently as older individuals, a phenomenon that has been attributed to immunological immaturity. Recently, we challenged this notion and proposed the presence of actively immunosuppressive and physiologically enriched CD71+ erythroid cells in neonates. Here we utilized Bordetella pertussis, a common neonatal respiratory tract pathogen, as a proof of concept to investigate the role of these cells in adaptive immunity. We observed that CD71+ cells have distinctive immunosuppressive properties and prevent recruitment of immune cells to the mucosal site of infection. CD71+ cells ablation unleashed induction of B. pertussis-specific protective cytokines (IL-17 and IFN-γ) in the lungs and spleen upon re-infection or vaccination. We also found that CD71+ cells suppress systemic and mucosal B. pertussis-specific antibody responses. Enhanced antigen-specific adaptive immunity following CD71+ cells depletion increased resistance of mice to B. pertussis infection. Furthermore, we found that human cord blood CD71+ cells also suppress T and B cell functions in vitro. Collectively, these data provide important insight into the role of CD71+ erythroid cells in adaptive immunity. We anticipate our results will spark renewed investigation in modulating the function of these cells to enhance host defense to infections in newborns.
format	article
author	Afshin Namdar Petya Koleva Shima Shahbaz Stacy Strom Volker Gerdts Shokrollah Elahi
author_facet	Afshin Namdar Petya Koleva Shima Shahbaz Stacy Strom Volker Gerdts Shokrollah Elahi
author_sort	Afshin Namdar
title	CD71+ erythroid suppressor cells impair adaptive immunity against Bordetella pertussis
title_short	CD71+ erythroid suppressor cells impair adaptive immunity against Bordetella pertussis
title_full	CD71+ erythroid suppressor cells impair adaptive immunity against Bordetella pertussis
title_fullStr	CD71+ erythroid suppressor cells impair adaptive immunity against Bordetella pertussis
title_full_unstemmed	CD71+ erythroid suppressor cells impair adaptive immunity against Bordetella pertussis
title_sort	cd71+ erythroid suppressor cells impair adaptive immunity against bordetella pertussis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f45ac271bb1740f7b3de8106fa477fd5
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CD71+ erythroid suppressor cells impair adaptive immunity against Bordetella pertussis

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