Association between diabetes status and subsequent onset of glaucoma in postmenopausal women

Abstract The purpose of this study was to analyze the risk of glaucoma based on diabetes status using a large nationwide longitudinal cohort of postmenopausal women. This study included 1,372,240 postmenopausal women aged ≥ 40 years who underwent National Health Screening Program in 2009. Subjects w...

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Autores principales:	Younhea Jung, Kyungdo Han, Kyoung Ohn, Da Ran Kim, Jung II Moon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f45d2387740c4b04b339d5e2155f4450
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spelling	oai:doaj.org-article:f45d2387740c4b04b339d5e2155f44502021-12-02T18:02:31ZAssociation between diabetes status and subsequent onset of glaucoma in postmenopausal women10.1038/s41598-021-97740-32045-2322https://doaj.org/article/f45d2387740c4b04b339d5e2155f44502021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97740-3https://doaj.org/toc/2045-2322Abstract The purpose of this study was to analyze the risk of glaucoma based on diabetes status using a large nationwide longitudinal cohort of postmenopausal women. This study included 1,372,240 postmenopausal women aged ≥ 40 years who underwent National Health Screening Program in 2009. Subjects were classified into the following 5 categories based on diabetes status: no diabetes, impaired fasting glucose (IFG), new onset diabetes, diabetes treated with oral hypoglycemic medication, and diabetes treated with insulin. Subjects were followed from 2005 through 2018, and hazard ratios of glaucoma onset were calculated for each group. Subgroup analyses of subjects stratified by age, smoking, drinking, hypertension, and dyslipidemia were performed. During the follow up period, 42,058 subjects developed glaucoma. The adjusted hazard ratio was 1.061 (95% CI, 1.036–1.086) in the IFG group, 1.151 (95% CI, 1.086–1.220) in the new onset diabetes group, 1.449 (95% CI, 1.406–1.493) in the diabetes treated with oral hypoglycemic medication group, and 1.884(95% CI, 1.777–1.999) in the diabetes treated with insulin group compared to the no diabetes group. The results were consistent in subgroup analyses after stratifying by age, lifestyle factors (smoking and drinking), and comorbidities (hypertension and dyslipidemia). Diabetes status is associated with increased risk of glaucoma development in postmenopausal women.Younhea JungKyungdo HanKyoung OhnDa Ran KimJung II MoonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Younhea Jung Kyungdo Han Kyoung Ohn Da Ran Kim Jung II Moon Association between diabetes status and subsequent onset of glaucoma in postmenopausal women
description	Abstract The purpose of this study was to analyze the risk of glaucoma based on diabetes status using a large nationwide longitudinal cohort of postmenopausal women. This study included 1,372,240 postmenopausal women aged ≥ 40 years who underwent National Health Screening Program in 2009. Subjects were classified into the following 5 categories based on diabetes status: no diabetes, impaired fasting glucose (IFG), new onset diabetes, diabetes treated with oral hypoglycemic medication, and diabetes treated with insulin. Subjects were followed from 2005 through 2018, and hazard ratios of glaucoma onset were calculated for each group. Subgroup analyses of subjects stratified by age, smoking, drinking, hypertension, and dyslipidemia were performed. During the follow up period, 42,058 subjects developed glaucoma. The adjusted hazard ratio was 1.061 (95% CI, 1.036–1.086) in the IFG group, 1.151 (95% CI, 1.086–1.220) in the new onset diabetes group, 1.449 (95% CI, 1.406–1.493) in the diabetes treated with oral hypoglycemic medication group, and 1.884(95% CI, 1.777–1.999) in the diabetes treated with insulin group compared to the no diabetes group. The results were consistent in subgroup analyses after stratifying by age, lifestyle factors (smoking and drinking), and comorbidities (hypertension and dyslipidemia). Diabetes status is associated with increased risk of glaucoma development in postmenopausal women.
format	article
author	Younhea Jung Kyungdo Han Kyoung Ohn Da Ran Kim Jung II Moon
author_facet	Younhea Jung Kyungdo Han Kyoung Ohn Da Ran Kim Jung II Moon
author_sort	Younhea Jung
title	Association between diabetes status and subsequent onset of glaucoma in postmenopausal women
title_short	Association between diabetes status and subsequent onset of glaucoma in postmenopausal women
title_full	Association between diabetes status and subsequent onset of glaucoma in postmenopausal women
title_fullStr	Association between diabetes status and subsequent onset of glaucoma in postmenopausal women
title_full_unstemmed	Association between diabetes status and subsequent onset of glaucoma in postmenopausal women
title_sort	association between diabetes status and subsequent onset of glaucoma in postmenopausal women
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f45d2387740c4b04b339d5e2155f4450
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Association between diabetes status and subsequent onset of glaucoma in postmenopausal women

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