Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division

Polarized localization of Numb and Pon in Drosophila neuroblasts (NBs) enables their unequal segregation during asymmetric cell divisions. Here, the authors demonstrate liquid-liquid phase separation of Pon and Numb in NBs mediated by multivalent intermolecular interactions is required for their bas...

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Autores principales:	Zelin Shan, Yuting Tu, Ying Yang, Ziheng Liu, Menglong Zeng, Huisha Xu, Jiafu Long, Mingjie Zhang, Yu Cai, Wenyu Wen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f45e83778d8742c9b81a80ceb914abed
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spelling	oai:doaj.org-article:f45e83778d8742c9b81a80ceb914abed2021-12-02T15:33:45ZBasal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division10.1038/s41467-018-03077-32041-1723https://doaj.org/article/f45e83778d8742c9b81a80ceb914abed2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03077-3https://doaj.org/toc/2041-1723Polarized localization of Numb and Pon in Drosophila neuroblasts (NBs) enables their unequal segregation during asymmetric cell divisions. Here, the authors demonstrate liquid-liquid phase separation of Pon and Numb in NBs mediated by multivalent intermolecular interactions is required for their basal condensation.Zelin ShanYuting TuYing YangZiheng LiuMenglong ZengHuisha XuJiafu LongMingjie ZhangYu CaiWenyu WenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zelin Shan Yuting Tu Ying Yang Ziheng Liu Menglong Zeng Huisha Xu Jiafu Long Mingjie Zhang Yu Cai Wenyu Wen Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division
description	Polarized localization of Numb and Pon in Drosophila neuroblasts (NBs) enables their unequal segregation during asymmetric cell divisions. Here, the authors demonstrate liquid-liquid phase separation of Pon and Numb in NBs mediated by multivalent intermolecular interactions is required for their basal condensation.
format	article
author	Zelin Shan Yuting Tu Ying Yang Ziheng Liu Menglong Zeng Huisha Xu Jiafu Long Mingjie Zhang Yu Cai Wenyu Wen
author_facet	Zelin Shan Yuting Tu Ying Yang Ziheng Liu Menglong Zeng Huisha Xu Jiafu Long Mingjie Zhang Yu Cai Wenyu Wen
author_sort	Zelin Shan
title	Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division
title_short	Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division
title_full	Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division
title_fullStr	Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division
title_full_unstemmed	Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division
title_sort	basal condensation of numb and pon complex via phase transition during drosophila neuroblast asymmetric division
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f45e83778d8742c9b81a80ceb914abed
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_version_	1718387060077756416

Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division

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