The Set1 N-terminal domain and Swd2 interact with RNA polymerase II CTD to recruit COMPASS

Methylation of histone H3 lysine 4 (H3K4) by Set1/COMPASS occurs co-transcriptionally, and is important for gene regulation. Here the authors provide evidence that the Set1 N-terminal region and the COMPASS subunit Swd2 interact with RNA polymerase II CTD to recruit COMPASS in budding yeast.

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Autores principales: Hyun Jin Bae, Marion Dubarry, Jongcheol Jeon, Luis M. Soares, Catherine Dargemont, Jaehoon Kim, Vincent Geli, Stephen Buratowski
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/f45ecf358a5a4b8a8f4052500b0aec19
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Sumario:Methylation of histone H3 lysine 4 (H3K4) by Set1/COMPASS occurs co-transcriptionally, and is important for gene regulation. Here the authors provide evidence that the Set1 N-terminal region and the COMPASS subunit Swd2 interact with RNA polymerase II CTD to recruit COMPASS in budding yeast.