Long-Term Evolution of Malnutrition and Loss of Muscle Strength after COVID-19: A Major and Neglected Component of Long COVID-19

Post-acute consequences of COVID-19, also termed long COVID, include signs and symptoms persisting for more than 12 weeks with prolonged multisystem involvement; most often, however, malnutrition is ignored. Method: The objective was to analyze persistent symptoms, nutritional status, the evolution...

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Autores principales:	Marine Gérard, Meliha Mahmutovic, Aurélie Malgras, Niasha Michot, Nicolas Scheyer, Roland Jaussaud, Phi-Linh Nguyen-Thi, Didier Quilliot
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	long COVID-19 muscle strength malnutrition self-evaluation obesity cohort study Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/f45f9361978347e592c4a8bcbe425ac1
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spelling	oai:doaj.org-article:f45f9361978347e592c4a8bcbe425ac12021-11-25T18:35:39ZLong-Term Evolution of Malnutrition and Loss of Muscle Strength after COVID-19: A Major and Neglected Component of Long COVID-1910.3390/nu131139642072-6643https://doaj.org/article/f45f9361978347e592c4a8bcbe425ac12021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3964https://doaj.org/toc/2072-6643Post-acute consequences of COVID-19, also termed long COVID, include signs and symptoms persisting for more than 12 weeks with prolonged multisystem involvement; most often, however, malnutrition is ignored. Method: The objective was to analyze persistent symptoms, nutritional status, the evolution of muscle strength and performance status (PS) at 6 months post-discharge in a cohort of COVID-19 survivors. Results: Of 549 consecutive patients hospitalized for COVID-19 between 1 March and 29 April 2020, 23.7% died and 288 patients were at home at D30 post-discharge. At this date, 136 of them (47.2%) presented persistent malnutrition, a significant decrease in muscle strength or a PS ≥ 2. These patients received dietary counseling, nutritional supplementation, adapted physical activity guidance or physiotherapy assistance, or were admitted to post-care facilities. At 6 months post-discharge, 91.0% of the 136 patients (n = 119) were evaluated and 36.0% had persistent malnutrition, 14.3% complained of a significant decrease in muscle strength and 14.9% had a performance status > 2. Obesity was more frequent in patients with impairment than in those without (52.8% vs. 31.0%; <i>p</i> = 0.0071), with these patients being admitted more frequently to ICUs (50.9% vs. 31.3%; <i>p</i> = 0.010). Among those with persistent symptoms, 10% had psychiatric co-morbidities (mood disorders, anxiety, or post-traumatic stress syndrome), 7.6% had prolonged pneumological symptoms and 4.2% had neurological symptoms. Conclusions: Obese subjects as well as patients who have stayed in intensive care have a higher risk of functional loss or undernutrition 6 months after a severe COVID infection. Malnutrition and loss of muscle strength should be considered in the clinical assessment of these patients.Marine GérardMeliha MahmutovicAurélie MalgrasNiasha MichotNicolas ScheyerRoland JaussaudPhi-Linh Nguyen-ThiDidier QuilliotMDPI AGarticlelong COVID-19muscle strengthmalnutritionself-evaluationobesitycohort studyNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3964, p 3964 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	long COVID-19 muscle strength malnutrition self-evaluation obesity cohort study Nutrition. Foods and food supply TX341-641
spellingShingle	long COVID-19 muscle strength malnutrition self-evaluation obesity cohort study Nutrition. Foods and food supply TX341-641 Marine Gérard Meliha Mahmutovic Aurélie Malgras Niasha Michot Nicolas Scheyer Roland Jaussaud Phi-Linh Nguyen-Thi Didier Quilliot Long-Term Evolution of Malnutrition and Loss of Muscle Strength after COVID-19: A Major and Neglected Component of Long COVID-19
description	Post-acute consequences of COVID-19, also termed long COVID, include signs and symptoms persisting for more than 12 weeks with prolonged multisystem involvement; most often, however, malnutrition is ignored. Method: The objective was to analyze persistent symptoms, nutritional status, the evolution of muscle strength and performance status (PS) at 6 months post-discharge in a cohort of COVID-19 survivors. Results: Of 549 consecutive patients hospitalized for COVID-19 between 1 March and 29 April 2020, 23.7% died and 288 patients were at home at D30 post-discharge. At this date, 136 of them (47.2%) presented persistent malnutrition, a significant decrease in muscle strength or a PS ≥ 2. These patients received dietary counseling, nutritional supplementation, adapted physical activity guidance or physiotherapy assistance, or were admitted to post-care facilities. At 6 months post-discharge, 91.0% of the 136 patients (n = 119) were evaluated and 36.0% had persistent malnutrition, 14.3% complained of a significant decrease in muscle strength and 14.9% had a performance status > 2. Obesity was more frequent in patients with impairment than in those without (52.8% vs. 31.0%; <i>p</i> = 0.0071), with these patients being admitted more frequently to ICUs (50.9% vs. 31.3%; <i>p</i> = 0.010). Among those with persistent symptoms, 10% had psychiatric co-morbidities (mood disorders, anxiety, or post-traumatic stress syndrome), 7.6% had prolonged pneumological symptoms and 4.2% had neurological symptoms. Conclusions: Obese subjects as well as patients who have stayed in intensive care have a higher risk of functional loss or undernutrition 6 months after a severe COVID infection. Malnutrition and loss of muscle strength should be considered in the clinical assessment of these patients.
format	article
author	Marine Gérard Meliha Mahmutovic Aurélie Malgras Niasha Michot Nicolas Scheyer Roland Jaussaud Phi-Linh Nguyen-Thi Didier Quilliot
author_facet	Marine Gérard Meliha Mahmutovic Aurélie Malgras Niasha Michot Nicolas Scheyer Roland Jaussaud Phi-Linh Nguyen-Thi Didier Quilliot
author_sort	Marine Gérard
title	Long-Term Evolution of Malnutrition and Loss of Muscle Strength after COVID-19: A Major and Neglected Component of Long COVID-19
title_short	Long-Term Evolution of Malnutrition and Loss of Muscle Strength after COVID-19: A Major and Neglected Component of Long COVID-19
title_full	Long-Term Evolution of Malnutrition and Loss of Muscle Strength after COVID-19: A Major and Neglected Component of Long COVID-19
title_fullStr	Long-Term Evolution of Malnutrition and Loss of Muscle Strength after COVID-19: A Major and Neglected Component of Long COVID-19
title_full_unstemmed	Long-Term Evolution of Malnutrition and Loss of Muscle Strength after COVID-19: A Major and Neglected Component of Long COVID-19
title_sort	long-term evolution of malnutrition and loss of muscle strength after covid-19: a major and neglected component of long covid-19
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f45f9361978347e592c4a8bcbe425ac1
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Long-Term Evolution of Malnutrition and Loss of Muscle Strength after COVID-19: A Major and Neglected Component of Long COVID-19

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