A prebiotic template-directed peptide synthesis based on amyloids

Amyloids may have played an important role in prebiotic molecular evolution but understanding replication of such information-coding molecules is still a problem. Here the authors design a model amyloid substrate and demonstrate sequence regio- and stereoselectivity during template-based replication...

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Autores principales:	Saroj K. Rout, Michael P. Friedmann, Roland Riek, Jason Greenwald
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f4617bced55d408e84bbb721d41321de
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spelling	oai:doaj.org-article:f4617bced55d408e84bbb721d41321de2021-12-02T14:41:07ZA prebiotic template-directed peptide synthesis based on amyloids10.1038/s41467-017-02742-32041-1723https://doaj.org/article/f4617bced55d408e84bbb721d41321de2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02742-3https://doaj.org/toc/2041-1723Amyloids may have played an important role in prebiotic molecular evolution but understanding replication of such information-coding molecules is still a problem. Here the authors design a model amyloid substrate and demonstrate sequence regio- and stereoselectivity during template-based replication.Saroj K. RoutMichael P. FriedmannRoland RiekJason GreenwaldNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Saroj K. Rout Michael P. Friedmann Roland Riek Jason Greenwald A prebiotic template-directed peptide synthesis based on amyloids
description	Amyloids may have played an important role in prebiotic molecular evolution but understanding replication of such information-coding molecules is still a problem. Here the authors design a model amyloid substrate and demonstrate sequence regio- and stereoselectivity during template-based replication.
format	article
author	Saroj K. Rout Michael P. Friedmann Roland Riek Jason Greenwald
author_facet	Saroj K. Rout Michael P. Friedmann Roland Riek Jason Greenwald
author_sort	Saroj K. Rout
title	A prebiotic template-directed peptide synthesis based on amyloids
title_short	A prebiotic template-directed peptide synthesis based on amyloids
title_full	A prebiotic template-directed peptide synthesis based on amyloids
title_fullStr	A prebiotic template-directed peptide synthesis based on amyloids
title_full_unstemmed	A prebiotic template-directed peptide synthesis based on amyloids
title_sort	prebiotic template-directed peptide synthesis based on amyloids
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f4617bced55d408e84bbb721d41321de
work_keys_str_mv	AT sarojkrout aprebiotictemplatedirectedpeptidesynthesisbasedonamyloids AT michaelpfriedmann aprebiotictemplatedirectedpeptidesynthesisbasedonamyloids AT rolandriek aprebiotictemplatedirectedpeptidesynthesisbasedonamyloids AT jasongreenwald aprebiotictemplatedirectedpeptidesynthesisbasedonamyloids AT sarojkrout prebiotictemplatedirectedpeptidesynthesisbasedonamyloids AT michaelpfriedmann prebiotictemplatedirectedpeptidesynthesisbasedonamyloids AT rolandriek prebiotictemplatedirectedpeptidesynthesisbasedonamyloids AT jasongreenwald prebiotictemplatedirectedpeptidesynthesisbasedonamyloids
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A prebiotic template-directed peptide synthesis based on amyloids

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