Nanomaterials Enhance the Immunomodulatory Effect of Molecular Targeted Therapy

Zhongmin Li, Yilun Liu, Xuedong Fang, Zhenbo Shu Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, People’s Republic of ChinaCorrespondence: Zhenbo Shu Email shuzb@jlu.edu.cnAbstract: Molecular targeted therapy, a...

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Autores principales:	Li Z, Liu Y, Fang X, Shu Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	nanomaterial molecular targeted therapy immunomodulation immunotherapy cancer therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f461ce49a63348e4b6eb09e5a3634b6a
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spelling	oai:doaj.org-article:f461ce49a63348e4b6eb09e5a3634b6a2021-12-02T14:40:41ZNanomaterials Enhance the Immunomodulatory Effect of Molecular Targeted Therapy1178-2013https://doaj.org/article/f461ce49a63348e4b6eb09e5a3634b6a2021-03-01T00:00:00Zhttps://www.dovepress.com/nanomaterials-enhance-the-immunomodulatory-effect-of-molecular-targete-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Zhongmin Li, Yilun Liu, Xuedong Fang, Zhenbo Shu Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, People’s Republic of ChinaCorrespondence: Zhenbo Shu Email shuzb@jlu.edu.cnAbstract: Molecular targeted therapy, a tumor therapy strategy that inhibits specific oncogenic targets, has been shown to modulate the immune response. In addition to directly inhibiting the proliferation and metastasis of tumor cells, molecular targeted drugs can activate the immune system through a variety of mechanisms, including by promoting tumor antigen processing and presentation, increasing intratumoral T cell infiltration, enhancing T cell activation and function, and attenuating the immunosuppressive effect of the tumor microenvironment. However, poor water solubility, insufficient accumulation at the tumor site, and nonspecific targeting of immune cells limit their application. To this end, a variety of nanomaterials have been developed to overcome these obstacles and amplify the immunomodulatory effects of molecular targeted drugs. In this review, we summarize the impact of molecular targeted drugs on the antitumor immune response according to their mechanisms, highlight the advantages of nanomaterials in enhancing the immunomodulatory effect of molecular targeted therapy, and discuss the current challenges and future prospects.Keywords: nanomaterial, molecular targeted therapy, immunomodulation, immunotherapy, cancer therapyLi ZLiu YFang XShu ZDove Medical Pressarticlenanomaterialmolecular targeted therapyimmunomodulationimmunotherapycancer therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 1631-1661 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanomaterial molecular targeted therapy immunomodulation immunotherapy cancer therapy Medicine (General) R5-920
spellingShingle	nanomaterial molecular targeted therapy immunomodulation immunotherapy cancer therapy Medicine (General) R5-920 Li Z Liu Y Fang X Shu Z Nanomaterials Enhance the Immunomodulatory Effect of Molecular Targeted Therapy
description	Zhongmin Li, Yilun Liu, Xuedong Fang, Zhenbo Shu Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, People’s Republic of ChinaCorrespondence: Zhenbo Shu Email shuzb@jlu.edu.cnAbstract: Molecular targeted therapy, a tumor therapy strategy that inhibits specific oncogenic targets, has been shown to modulate the immune response. In addition to directly inhibiting the proliferation and metastasis of tumor cells, molecular targeted drugs can activate the immune system through a variety of mechanisms, including by promoting tumor antigen processing and presentation, increasing intratumoral T cell infiltration, enhancing T cell activation and function, and attenuating the immunosuppressive effect of the tumor microenvironment. However, poor water solubility, insufficient accumulation at the tumor site, and nonspecific targeting of immune cells limit their application. To this end, a variety of nanomaterials have been developed to overcome these obstacles and amplify the immunomodulatory effects of molecular targeted drugs. In this review, we summarize the impact of molecular targeted drugs on the antitumor immune response according to their mechanisms, highlight the advantages of nanomaterials in enhancing the immunomodulatory effect of molecular targeted therapy, and discuss the current challenges and future prospects.Keywords: nanomaterial, molecular targeted therapy, immunomodulation, immunotherapy, cancer therapy
format	article
author	Li Z Liu Y Fang X Shu Z
author_facet	Li Z Liu Y Fang X Shu Z
author_sort	Li Z
title	Nanomaterials Enhance the Immunomodulatory Effect of Molecular Targeted Therapy
title_short	Nanomaterials Enhance the Immunomodulatory Effect of Molecular Targeted Therapy
title_full	Nanomaterials Enhance the Immunomodulatory Effect of Molecular Targeted Therapy
title_fullStr	Nanomaterials Enhance the Immunomodulatory Effect of Molecular Targeted Therapy
title_full_unstemmed	Nanomaterials Enhance the Immunomodulatory Effect of Molecular Targeted Therapy
title_sort	nanomaterials enhance the immunomodulatory effect of molecular targeted therapy
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/f461ce49a63348e4b6eb09e5a3634b6a
work_keys_str_mv	AT liz nanomaterialsenhancetheimmunomodulatoryeffectofmoleculartargetedtherapy AT liuy nanomaterialsenhancetheimmunomodulatoryeffectofmoleculartargetedtherapy AT fangx nanomaterialsenhancetheimmunomodulatoryeffectofmoleculartargetedtherapy AT shuz nanomaterialsenhancetheimmunomodulatoryeffectofmoleculartargetedtherapy
_version_	1718390210341896192

Nanomaterials Enhance the Immunomodulatory Effect of Molecular Targeted Therapy

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