Maintenance of epigenetic landscape requires CIZ1 and is corrupted in differentiated fibroblasts in long-term culture

The inactive X chromosome (Xi) is a model for establishment and maintenance of repressed chromatin and the function of polycomb repressive complexes. Here the authors show that Xi transiently relocates from the nuclear periphery during replication in a CIZ1-dependent manner, which plays a role in ma...

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Autores principales:	Emma R. Stewart, Robert M. L. Turner, Katherine Newling, Rebeca Ridings-Figueroa, Victoria Scott, Peter D. Ashton, Justin F. X. Ainscough, Dawn Coverley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f461e6cb469a41aaaa4bb9b78a0b0508
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spelling	oai:doaj.org-article:f461e6cb469a41aaaa4bb9b78a0b05082021-12-02T17:01:53ZMaintenance of epigenetic landscape requires CIZ1 and is corrupted in differentiated fibroblasts in long-term culture10.1038/s41467-018-08072-22041-1723https://doaj.org/article/f461e6cb469a41aaaa4bb9b78a0b05082019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08072-2https://doaj.org/toc/2041-1723The inactive X chromosome (Xi) is a model for establishment and maintenance of repressed chromatin and the function of polycomb repressive complexes. Here the authors show that Xi transiently relocates from the nuclear periphery during replication in a CIZ1-dependent manner, which plays a role in maintaining PRC-mediated repressed chromatin.Emma R. StewartRobert M. L. TurnerKatherine NewlingRebeca Ridings-FigueroaVictoria ScottPeter D. AshtonJustin F. X. AinscoughDawn CoverleyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emma R. Stewart Robert M. L. Turner Katherine Newling Rebeca Ridings-Figueroa Victoria Scott Peter D. Ashton Justin F. X. Ainscough Dawn Coverley Maintenance of epigenetic landscape requires CIZ1 and is corrupted in differentiated fibroblasts in long-term culture
description	The inactive X chromosome (Xi) is a model for establishment and maintenance of repressed chromatin and the function of polycomb repressive complexes. Here the authors show that Xi transiently relocates from the nuclear periphery during replication in a CIZ1-dependent manner, which plays a role in maintaining PRC-mediated repressed chromatin.
format	article
author	Emma R. Stewart Robert M. L. Turner Katherine Newling Rebeca Ridings-Figueroa Victoria Scott Peter D. Ashton Justin F. X. Ainscough Dawn Coverley
author_facet	Emma R. Stewart Robert M. L. Turner Katherine Newling Rebeca Ridings-Figueroa Victoria Scott Peter D. Ashton Justin F. X. Ainscough Dawn Coverley
author_sort	Emma R. Stewart
title	Maintenance of epigenetic landscape requires CIZ1 and is corrupted in differentiated fibroblasts in long-term culture
title_short	Maintenance of epigenetic landscape requires CIZ1 and is corrupted in differentiated fibroblasts in long-term culture
title_full	Maintenance of epigenetic landscape requires CIZ1 and is corrupted in differentiated fibroblasts in long-term culture
title_fullStr	Maintenance of epigenetic landscape requires CIZ1 and is corrupted in differentiated fibroblasts in long-term culture
title_full_unstemmed	Maintenance of epigenetic landscape requires CIZ1 and is corrupted in differentiated fibroblasts in long-term culture
title_sort	maintenance of epigenetic landscape requires ciz1 and is corrupted in differentiated fibroblasts in long-term culture
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f461e6cb469a41aaaa4bb9b78a0b0508
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Maintenance of epigenetic landscape requires CIZ1 and is corrupted in differentiated fibroblasts in long-term culture

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