Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers

Neural precursor cell expressed developmentally downregulated 4-like (NEDD4L) is an E3 ubiquitin ligase that has been reported to participate in multiple cellular procedures by regulating of substrate ubiquitination and subsequent protein degradation. A great amount of evidence has demonstrated that...

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Autores principales:	Shangdan Xie, Lu Xia, Yizuo Song, Hejing Liu, Zhi-wei Wang, Xueqiong Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	NEDD4L ubiquitination cancer treatment degradation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/f46429394576467299028e0d92d37359
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spelling	oai:doaj.org-article:f46429394576467299028e0d92d373592021-11-15T04:31:17ZInsights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers2234-943X10.3389/fonc.2021.774648https://doaj.org/article/f46429394576467299028e0d92d373592021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.774648/fullhttps://doaj.org/toc/2234-943XNeural precursor cell expressed developmentally downregulated 4-like (NEDD4L) is an E3 ubiquitin ligase that has been reported to participate in multiple cellular procedures by regulating of substrate ubiquitination and subsequent protein degradation. A great amount of evidence has demonstrated that NEDD4L mainly functions as a tumor suppressor in most cancer types, while it also acts as an oncogene in a few cancers. In this review, we summarize the potential role of NEDD4L in carcinogenesis and the related underlying molecular mechanism to improve our understanding of its functions in the tumorigenesis of human malignancies. Developing clinical drugs targeting NEDD4L could be a potential therapeutic strategy for cancer therapy in the future.Shangdan XieLu XiaYizuo SongHejing LiuZhi-wei WangXueqiong ZhuFrontiers Media S.A.articleNEDD4LubiquitinationcancertreatmentdegradationNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NEDD4L ubiquitination cancer treatment degradation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	NEDD4L ubiquitination cancer treatment degradation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Shangdan Xie Lu Xia Yizuo Song Hejing Liu Zhi-wei Wang Xueqiong Zhu Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers
description	Neural precursor cell expressed developmentally downregulated 4-like (NEDD4L) is an E3 ubiquitin ligase that has been reported to participate in multiple cellular procedures by regulating of substrate ubiquitination and subsequent protein degradation. A great amount of evidence has demonstrated that NEDD4L mainly functions as a tumor suppressor in most cancer types, while it also acts as an oncogene in a few cancers. In this review, we summarize the potential role of NEDD4L in carcinogenesis and the related underlying molecular mechanism to improve our understanding of its functions in the tumorigenesis of human malignancies. Developing clinical drugs targeting NEDD4L could be a potential therapeutic strategy for cancer therapy in the future.
format	article
author	Shangdan Xie Lu Xia Yizuo Song Hejing Liu Zhi-wei Wang Xueqiong Zhu
author_facet	Shangdan Xie Lu Xia Yizuo Song Hejing Liu Zhi-wei Wang Xueqiong Zhu
author_sort	Shangdan Xie
title	Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers
title_short	Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers
title_full	Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers
title_fullStr	Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers
title_full_unstemmed	Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers
title_sort	insights into the biological role of nedd4l e3 ubiquitin ligase in human cancers
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f46429394576467299028e0d92d37359
work_keys_str_mv	AT shangdanxie insightsintothebiologicalroleofnedd4le3ubiquitinligaseinhumancancers AT luxia insightsintothebiologicalroleofnedd4le3ubiquitinligaseinhumancancers AT yizuosong insightsintothebiologicalroleofnedd4le3ubiquitinligaseinhumancancers AT hejingliu insightsintothebiologicalroleofnedd4le3ubiquitinligaseinhumancancers AT zhiweiwang insightsintothebiologicalroleofnedd4le3ubiquitinligaseinhumancancers AT xueqiongzhu insightsintothebiologicalroleofnedd4le3ubiquitinligaseinhumancancers
_version_	1718428842267246592

Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers

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