Combination of Auranofin and ICG-001 Suppress the Proliferation and Metastasis of Colon Cancer

Colon cancer is one of the deadliest tumors in the world, and with high metastasis rate and mortality, effective drugs for its treatment are still in need. Auranofin (AF) is a gold complex that has been attested by FDA for treating human rheumatism, and researchers have found that AF acts as a great...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhaoyan Lin, Qingqing Li, Ying Zhao, Zixiang Lin, Nan Cheng, Di Zhang, Gang Liu, Jiahao Lin, Hong Zhang, Degui Lin
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ICG-001 auranofin colon cancer proliferation metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/f4668ffe220d418fa150cd85d8a06078
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f4668ffe220d418fa150cd85d8a06078
record_format	dspace
spelling	oai:doaj.org-article:f4668ffe220d418fa150cd85d8a060782021-11-30T17:05:52ZCombination of Auranofin and ICG-001 Suppress the Proliferation and Metastasis of Colon Cancer2234-943X10.3389/fonc.2021.738085https://doaj.org/article/f4668ffe220d418fa150cd85d8a060782021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.738085/fullhttps://doaj.org/toc/2234-943XColon cancer is one of the deadliest tumors in the world, and with high metastasis rate and mortality, effective drugs for its treatment are still in need. Auranofin (AF) is a gold complex that has been attested by FDA for treating human rheumatism, and researchers have found that AF acts as a great antitumor drug in recent years. ICG-001 is a small molecule inhibitor of Wnt/β-catenin pathway. In the present study, we aimed to explore the synergistic antitumor effects and the underlying mechanisms of AF and ICG-001 combination therapy on human colon cancer. The results showed that AF and ICG-001 synergistically depressed the growth and invasion of human colon cancer cells by inhibiting the phosphorylation of Signal Transducer and Activator of Transcription 3 (STAT3) and its downstream mediator B-cell lymphoma-2-like 1 (Bcl-xL) and inducing caspase-3-dependent apoptosis. Moreover, AF combined with ICG-001 synergistically inhibited the growth of colon cancer in subcutaneous xenograft mice models and restrained metastasis in lung metastasis mice models. In conclusion, our results demonstrated that combination of AF and ICG-001 suppressed the proliferation and metastasis of colon cancer by inhibiting STAT3 phosphorylation. Therefore, this combination therapy may possess potential therapeutic properties for human colon cancer.Zhaoyan LinQingqing LiYing ZhaoZixiang LinNan ChengDi ZhangGang LiuJiahao LinHong ZhangDegui LinFrontiers Media S.A.articleICG-001auranofincolon cancerproliferationmetastasisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ICG-001 auranofin colon cancer proliferation metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	ICG-001 auranofin colon cancer proliferation metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Zhaoyan Lin Qingqing Li Ying Zhao Zixiang Lin Nan Cheng Di Zhang Gang Liu Jiahao Lin Hong Zhang Degui Lin Combination of Auranofin and ICG-001 Suppress the Proliferation and Metastasis of Colon Cancer
description	Colon cancer is one of the deadliest tumors in the world, and with high metastasis rate and mortality, effective drugs for its treatment are still in need. Auranofin (AF) is a gold complex that has been attested by FDA for treating human rheumatism, and researchers have found that AF acts as a great antitumor drug in recent years. ICG-001 is a small molecule inhibitor of Wnt/β-catenin pathway. In the present study, we aimed to explore the synergistic antitumor effects and the underlying mechanisms of AF and ICG-001 combination therapy on human colon cancer. The results showed that AF and ICG-001 synergistically depressed the growth and invasion of human colon cancer cells by inhibiting the phosphorylation of Signal Transducer and Activator of Transcription 3 (STAT3) and its downstream mediator B-cell lymphoma-2-like 1 (Bcl-xL) and inducing caspase-3-dependent apoptosis. Moreover, AF combined with ICG-001 synergistically inhibited the growth of colon cancer in subcutaneous xenograft mice models and restrained metastasis in lung metastasis mice models. In conclusion, our results demonstrated that combination of AF and ICG-001 suppressed the proliferation and metastasis of colon cancer by inhibiting STAT3 phosphorylation. Therefore, this combination therapy may possess potential therapeutic properties for human colon cancer.
format	article
author	Zhaoyan Lin Qingqing Li Ying Zhao Zixiang Lin Nan Cheng Di Zhang Gang Liu Jiahao Lin Hong Zhang Degui Lin
author_facet	Zhaoyan Lin Qingqing Li Ying Zhao Zixiang Lin Nan Cheng Di Zhang Gang Liu Jiahao Lin Hong Zhang Degui Lin
author_sort	Zhaoyan Lin
title	Combination of Auranofin and ICG-001 Suppress the Proliferation and Metastasis of Colon Cancer
title_short	Combination of Auranofin and ICG-001 Suppress the Proliferation and Metastasis of Colon Cancer
title_full	Combination of Auranofin and ICG-001 Suppress the Proliferation and Metastasis of Colon Cancer
title_fullStr	Combination of Auranofin and ICG-001 Suppress the Proliferation and Metastasis of Colon Cancer
title_full_unstemmed	Combination of Auranofin and ICG-001 Suppress the Proliferation and Metastasis of Colon Cancer
title_sort	combination of auranofin and icg-001 suppress the proliferation and metastasis of colon cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f4668ffe220d418fa150cd85d8a06078
work_keys_str_mv	AT zhaoyanlin combinationofauranofinandicg001suppresstheproliferationandmetastasisofcoloncancer AT qingqingli combinationofauranofinandicg001suppresstheproliferationandmetastasisofcoloncancer AT yingzhao combinationofauranofinandicg001suppresstheproliferationandmetastasisofcoloncancer AT zixianglin combinationofauranofinandicg001suppresstheproliferationandmetastasisofcoloncancer AT nancheng combinationofauranofinandicg001suppresstheproliferationandmetastasisofcoloncancer AT dizhang combinationofauranofinandicg001suppresstheproliferationandmetastasisofcoloncancer AT gangliu combinationofauranofinandicg001suppresstheproliferationandmetastasisofcoloncancer AT jiahaolin combinationofauranofinandicg001suppresstheproliferationandmetastasisofcoloncancer AT hongzhang combinationofauranofinandicg001suppresstheproliferationandmetastasisofcoloncancer AT deguilin combinationofauranofinandicg001suppresstheproliferationandmetastasisofcoloncancer
_version_	1718406420204879872

Combination of Auranofin and ICG-001 Suppress the Proliferation and Metastasis of Colon Cancer

Ejemplares similares