The effects of aspirin on the outcome of COVID-19: A systematic review and meta-analysis

Background: Repurposing the use of aspirin to treat hospitalized patients with COVID-19 is a sensible approach. However, several previous studies showed conflicting results. This meta-analysis was aimed to assess the effect of aspirin on the outcome in patients with COVID-19. Methods: Systematic sea...

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Autores principales:	Indra Wijaya, Rizky Andhika, Ian Huang, Aga Purwiga, Kevin Yonatan Budiman
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Aspirin Acetylsalicylic acid SARS-CoV-2 COVID-19 Mortality Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/f4679aaf817945758256ea4fcab349d6
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spelling	oai:doaj.org-article:f4679aaf817945758256ea4fcab349d62021-11-10T04:25:46ZThe effects of aspirin on the outcome of COVID-19: A systematic review and meta-analysis2213-398410.1016/j.cegh.2021.100883https://doaj.org/article/f4679aaf817945758256ea4fcab349d62021-10-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213398421001913https://doaj.org/toc/2213-3984Background: Repurposing the use of aspirin to treat hospitalized patients with COVID-19 is a sensible approach. However, several previous studies showed conflicting results. This meta-analysis was aimed to assess the effect of aspirin on the outcome in patients with COVID-19. Methods: Systematic search using relevant keywords was carried out via several electronic databases until February 21, 2021. Research studies on adults COVID-19 patients with documentation on the use of aspirin and reported our outcomes of interest were included in the analysis. Our main outcome of interest was all types of mortality, while the incidence of thrombosis and bleeding were considered as secondary outcomes. Estimated risk estimates of the included studies were then pooled using DerSimonian-Laird random-effect models regardless heterogeneity. Results: Seven studies with a total of 34,415 patients were included in this systematic review and meta-analysis. The use of aspirin was associated with a reduced risk of mortality (RR 0.56, 95% CI 0.38–0.81, P = 0.002; I2: 68%, P = 0.005). Sensitivity analysis by differentiating in-hospital (active aspirin prescription) and pre-hospital use of aspirin could significantly reduce the heterogeneity (I2: 1%, P = 0.4). Only one study reported the incidence of major bleeding between aspirin and non-aspirin users (6.1% vs. 7.6%, P = 0.61). The association between the use of aspirin and the incidence of thrombosis were contradictory in two studies. Conclusion: The use of aspirin was significantly associated with a reduced risk of mortality among patients with COVID-19. Due to limited studies, the effect of aspirin on the incidence of thrombosis and bleeding in patients with COVID-19 could not be drawn definitively.Indra WijayaRizky AndhikaIan HuangAga PurwigaKevin Yonatan BudimanElsevierarticleAspirinAcetylsalicylic acidSARS-CoV-2COVID-19MortalityPublic aspects of medicineRA1-1270ENClinical Epidemiology and Global Health, Vol 12, Iss , Pp 100883- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Aspirin Acetylsalicylic acid SARS-CoV-2 COVID-19 Mortality Public aspects of medicine RA1-1270
spellingShingle	Aspirin Acetylsalicylic acid SARS-CoV-2 COVID-19 Mortality Public aspects of medicine RA1-1270 Indra Wijaya Rizky Andhika Ian Huang Aga Purwiga Kevin Yonatan Budiman The effects of aspirin on the outcome of COVID-19: A systematic review and meta-analysis
description	Background: Repurposing the use of aspirin to treat hospitalized patients with COVID-19 is a sensible approach. However, several previous studies showed conflicting results. This meta-analysis was aimed to assess the effect of aspirin on the outcome in patients with COVID-19. Methods: Systematic search using relevant keywords was carried out via several electronic databases until February 21, 2021. Research studies on adults COVID-19 patients with documentation on the use of aspirin and reported our outcomes of interest were included in the analysis. Our main outcome of interest was all types of mortality, while the incidence of thrombosis and bleeding were considered as secondary outcomes. Estimated risk estimates of the included studies were then pooled using DerSimonian-Laird random-effect models regardless heterogeneity. Results: Seven studies with a total of 34,415 patients were included in this systematic review and meta-analysis. The use of aspirin was associated with a reduced risk of mortality (RR 0.56, 95% CI 0.38–0.81, P = 0.002; I2: 68%, P = 0.005). Sensitivity analysis by differentiating in-hospital (active aspirin prescription) and pre-hospital use of aspirin could significantly reduce the heterogeneity (I2: 1%, P = 0.4). Only one study reported the incidence of major bleeding between aspirin and non-aspirin users (6.1% vs. 7.6%, P = 0.61). The association between the use of aspirin and the incidence of thrombosis were contradictory in two studies. Conclusion: The use of aspirin was significantly associated with a reduced risk of mortality among patients with COVID-19. Due to limited studies, the effect of aspirin on the incidence of thrombosis and bleeding in patients with COVID-19 could not be drawn definitively.
format	article
author	Indra Wijaya Rizky Andhika Ian Huang Aga Purwiga Kevin Yonatan Budiman
author_facet	Indra Wijaya Rizky Andhika Ian Huang Aga Purwiga Kevin Yonatan Budiman
author_sort	Indra Wijaya
title	The effects of aspirin on the outcome of COVID-19: A systematic review and meta-analysis
title_short	The effects of aspirin on the outcome of COVID-19: A systematic review and meta-analysis
title_full	The effects of aspirin on the outcome of COVID-19: A systematic review and meta-analysis
title_fullStr	The effects of aspirin on the outcome of COVID-19: A systematic review and meta-analysis
title_full_unstemmed	The effects of aspirin on the outcome of COVID-19: A systematic review and meta-analysis
title_sort	effects of aspirin on the outcome of covid-19: a systematic review and meta-analysis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f4679aaf817945758256ea4fcab349d6
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The effects of aspirin on the outcome of COVID-19: A systematic review and meta-analysis

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