Bioavailability of nanoemulsified conjugated linoleic acid for an antiobesity effect

Dongyeop Kim,1,3* Jin-Hong Park,2* Dae-Jun Kweon,2 Gi Dong Han11Department of Food Science and Technology, College of Natural Resources, Yeungnam University, Gyeongsan, Republic of Korea; 2BioHealth Convergence Center, Daegu Technopark, Daegu, Republic of Korea; 3Division of Applied Bioscience, Grad...

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Autores principales:	Kim D, Park JH, Kweon DJ, Han GD
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f46a55f205924d068d095514353656f6
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spelling	oai:doaj.org-article:f46a55f205924d068d095514353656f62021-12-02T01:07:52ZBioavailability of nanoemulsified conjugated linoleic acid for an antiobesity effect1176-91141178-2013https://doaj.org/article/f46a55f205924d068d095514353656f62013-02-01T00:00:00Zhttp://www.dovepress.com/bioavailability-of-nanoemulsified-conjugated-linoleic-acid-for-an-anti-a12123https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Dongyeop Kim,1,3* Jin-Hong Park,2* Dae-Jun Kweon,2 Gi Dong Han11Department of Food Science and Technology, College of Natural Resources, Yeungnam University, Gyeongsan, Republic of Korea; 2BioHealth Convergence Center, Daegu Technopark, Daegu, Republic of Korea; 3Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan *These authors contributed equally to this workBackground: The aim of this study was to enhance the bioavailability of conjugated linoleic acid (CLA), which has low water solubility, using nanoemulsion technology and to evaluate the effects of its improved bioavailability as an antiobesity agent.Methods: The antiobesity effect of nanoemulsified water-soluble conjugated linoleic acid (N-CLA) was evaluated using in vitro and in vivo studies. Differentiated 3T3-L1 adipocytes were treated with CLA and N-CLA to assess their lipolytic effect. Further, to confirm the antiobesity effect of N-CLA, male Sprague-Dawley rats were randomly separated into four groups, ie, a group fed a normal diet, a group fed a high-fat diet (obesity rat model), a CLA-treated group, and an N-CLA-treated group.Results: N-CLA showed a greater lipolytic effect on differentiated 3T3-L1 adipocytes compared with normal CLA. N-CLA enhanced the release of glycerol from triglycerides, which accumulated in differentiated 3T3-L1 adipocytes. Further, N-CLA enhanced leptin secretion to an extent similar to that of orlistat, an antiobesity agent. In an animal obesity model fed a high-fat diet, N-CLA attenuated accumulation of triglycerides, total cholesterol, and low-density lipoprotein cholesterol in serum, and also significantly decreased the volume of triglycerides and cholesterol in liver tissue.Conclusion: These results indicate that N-CLA has a greater antiobesity effect than CLA as a result of its improved bioavailability.Keywords: conjugated linoleic acid, nanoemulsion, water-soluble, improved bioavailability, antiobesityKim DPark JHKweon DJHan GDDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 451-459 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Kim D Park JH Kweon DJ Han GD Bioavailability of nanoemulsified conjugated linoleic acid for an antiobesity effect
description	Dongyeop Kim,1,3* Jin-Hong Park,2* Dae-Jun Kweon,2 Gi Dong Han11Department of Food Science and Technology, College of Natural Resources, Yeungnam University, Gyeongsan, Republic of Korea; 2BioHealth Convergence Center, Daegu Technopark, Daegu, Republic of Korea; 3Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan *These authors contributed equally to this workBackground: The aim of this study was to enhance the bioavailability of conjugated linoleic acid (CLA), which has low water solubility, using nanoemulsion technology and to evaluate the effects of its improved bioavailability as an antiobesity agent.Methods: The antiobesity effect of nanoemulsified water-soluble conjugated linoleic acid (N-CLA) was evaluated using in vitro and in vivo studies. Differentiated 3T3-L1 adipocytes were treated with CLA and N-CLA to assess their lipolytic effect. Further, to confirm the antiobesity effect of N-CLA, male Sprague-Dawley rats were randomly separated into four groups, ie, a group fed a normal diet, a group fed a high-fat diet (obesity rat model), a CLA-treated group, and an N-CLA-treated group.Results: N-CLA showed a greater lipolytic effect on differentiated 3T3-L1 adipocytes compared with normal CLA. N-CLA enhanced the release of glycerol from triglycerides, which accumulated in differentiated 3T3-L1 adipocytes. Further, N-CLA enhanced leptin secretion to an extent similar to that of orlistat, an antiobesity agent. In an animal obesity model fed a high-fat diet, N-CLA attenuated accumulation of triglycerides, total cholesterol, and low-density lipoprotein cholesterol in serum, and also significantly decreased the volume of triglycerides and cholesterol in liver tissue.Conclusion: These results indicate that N-CLA has a greater antiobesity effect than CLA as a result of its improved bioavailability.Keywords: conjugated linoleic acid, nanoemulsion, water-soluble, improved bioavailability, antiobesity
format	article
author	Kim D Park JH Kweon DJ Han GD
author_facet	Kim D Park JH Kweon DJ Han GD
author_sort	Kim D
title	Bioavailability of nanoemulsified conjugated linoleic acid for an antiobesity effect
title_short	Bioavailability of nanoemulsified conjugated linoleic acid for an antiobesity effect
title_full	Bioavailability of nanoemulsified conjugated linoleic acid for an antiobesity effect
title_fullStr	Bioavailability of nanoemulsified conjugated linoleic acid for an antiobesity effect
title_full_unstemmed	Bioavailability of nanoemulsified conjugated linoleic acid for an antiobesity effect
title_sort	bioavailability of nanoemulsified conjugated linoleic acid for an antiobesity effect
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/f46a55f205924d068d095514353656f6
work_keys_str_mv	AT kimd bioavailabilityofnanoemulsifiedconjugatedlinoleicacidforanantiobesityeffect AT parkjh bioavailabilityofnanoemulsifiedconjugatedlinoleicacidforanantiobesityeffect AT kweondj bioavailabilityofnanoemulsifiedconjugatedlinoleicacidforanantiobesityeffect AT hangd bioavailabilityofnanoemulsifiedconjugatedlinoleicacidforanantiobesityeffect
_version_	1718403292635070464

Bioavailability of nanoemulsified conjugated linoleic acid for an antiobesity effect

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