Paper-Based Point-of-Care Testing of SARS-CoV-2

The COVID-19 pandemic has resulted in significant global social and economic disruption. The highly transmissive nature of the disease makes rapid and reliable detection critically important. Point-of-care (POC) tests involve performing diagnostic tests outside of a laboratory that produce a rapid a...

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Autores principales:	Yuan Jia, Hao Sun, Jinpeng Tian, Qiuming Song, Wenwei Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	paper-based point-of-care COVID-19 diagnostics immunoassay CRISPR Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/f46c5df2cbd040138fbfccb29f93cd4d
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spelling	oai:doaj.org-article:f46c5df2cbd040138fbfccb29f93cd4d2021-12-01T13:22:04ZPaper-Based Point-of-Care Testing of SARS-CoV-22296-418510.3389/fbioe.2021.773304https://doaj.org/article/f46c5df2cbd040138fbfccb29f93cd4d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.773304/fullhttps://doaj.org/toc/2296-4185The COVID-19 pandemic has resulted in significant global social and economic disruption. The highly transmissive nature of the disease makes rapid and reliable detection critically important. Point-of-care (POC) tests involve performing diagnostic tests outside of a laboratory that produce a rapid and reliable result. It therefore allows the diagnostics of diseases at or near the patient site. Paper-based POC tests have been gaining interest in recent years as they allow rapid, low-cost detection without the need for external instruments. In this review, we focus on the development of paper-based POC devices for the detection of SARS-CoV-2. The review first introduces the principles of detection methods that are available to paper-based devices. It then summarizes the state-of-the-art paper devices and their analytical performances. The advantages and drawbacks among methods are also discussed. Finally, limitations of the existing devices are discussed, and prospects are given with the hope to identify research opportunities and directions in the field. We hope this review will be helpful for researchers to develop a clinically useful and economically efficient paper-based platform that can be used for rapid, accurate on-site diagnosis to aid in identifying acute infections and eventually contain the COVID-19 pandemic.Yuan JiaHao SunJinpeng TianQiuming SongWenwei ZhangFrontiers Media S.A.articlepaper-basedpoint-of-careCOVID-19 diagnosticsimmunoassayCRISPRBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	paper-based point-of-care COVID-19 diagnostics immunoassay CRISPR Biotechnology TP248.13-248.65
spellingShingle	paper-based point-of-care COVID-19 diagnostics immunoassay CRISPR Biotechnology TP248.13-248.65 Yuan Jia Hao Sun Jinpeng Tian Qiuming Song Wenwei Zhang Paper-Based Point-of-Care Testing of SARS-CoV-2
description	The COVID-19 pandemic has resulted in significant global social and economic disruption. The highly transmissive nature of the disease makes rapid and reliable detection critically important. Point-of-care (POC) tests involve performing diagnostic tests outside of a laboratory that produce a rapid and reliable result. It therefore allows the diagnostics of diseases at or near the patient site. Paper-based POC tests have been gaining interest in recent years as they allow rapid, low-cost detection without the need for external instruments. In this review, we focus on the development of paper-based POC devices for the detection of SARS-CoV-2. The review first introduces the principles of detection methods that are available to paper-based devices. It then summarizes the state-of-the-art paper devices and their analytical performances. The advantages and drawbacks among methods are also discussed. Finally, limitations of the existing devices are discussed, and prospects are given with the hope to identify research opportunities and directions in the field. We hope this review will be helpful for researchers to develop a clinically useful and economically efficient paper-based platform that can be used for rapid, accurate on-site diagnosis to aid in identifying acute infections and eventually contain the COVID-19 pandemic.
format	article
author	Yuan Jia Hao Sun Jinpeng Tian Qiuming Song Wenwei Zhang
author_facet	Yuan Jia Hao Sun Jinpeng Tian Qiuming Song Wenwei Zhang
author_sort	Yuan Jia
title	Paper-Based Point-of-Care Testing of SARS-CoV-2
title_short	Paper-Based Point-of-Care Testing of SARS-CoV-2
title_full	Paper-Based Point-of-Care Testing of SARS-CoV-2
title_fullStr	Paper-Based Point-of-Care Testing of SARS-CoV-2
title_full_unstemmed	Paper-Based Point-of-Care Testing of SARS-CoV-2
title_sort	paper-based point-of-care testing of sars-cov-2
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f46c5df2cbd040138fbfccb29f93cd4d
work_keys_str_mv	AT yuanjia paperbasedpointofcaretestingofsarscov2 AT haosun paperbasedpointofcaretestingofsarscov2 AT jinpengtian paperbasedpointofcaretestingofsarscov2 AT qiumingsong paperbasedpointofcaretestingofsarscov2 AT wenweizhang paperbasedpointofcaretestingofsarscov2
_version_	1718405151995199488

Paper-Based Point-of-Care Testing of SARS-CoV-2

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