Timed action of IL-27 protects from immunopathology while preserving defense in influenza.

Infection with influenza virus can result in massive pulmonary infiltration and potentially fatal immunopathology. Understanding the endogenous mechanisms that control immunopathology could provide a key to novel adjunct therapies for this disease. Here we show that the cytokine IL-27 plays a crucia...

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Auteurs principaux:	Francesca Diane M Liu, Elisabeth E Kenngott, Micha F Schröter, Anja Kühl, Silke Jennrich, Ralf Watzlawick, Ute Hoffmann, Thorsten Wolff, Stephen Norley, Alexander Scheffold, Jason S Stumhofer, Christiaan J M Saris, Jan M Schwab, Christopher A Hunter, Gudrun F Debes, Alf Hamann
Format:	article
Langue:	EN
Publié:	Public Library of Science (PLoS) 2014
Sujets:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/f46c7abf103043808e7e70a88af3992e
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Timed action of IL-27 protects from immunopathology while preserving defense in influenza.

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