Comparison of the effect of two therapeutic exercises on the inflammatory and physiological conditions and complications of diabetic neuropathy in female patients

Maryam Nadi,1 Effat Bambaeichi,2 Seyyed Mohammad Marandi21Exercise Physiology, University of Isfahan, Isfahan, Iran; 2Faculty of Sport Sciences Department, University of Isfahan, Isfahan, IranCorrespondence: Effat BambaeichiFaculty of Sport Sciences Department, University of Isfahan, Azadi Square, I...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nadi M, Bambaeichi E, Marandi SM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	TNF-α IL-10 CRP and diabetic neuropathy exercises Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/f46e8868c0b7482f8a80622f8b36d9fe
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f46e8868c0b7482f8a80622f8b36d9fe
record_format	dspace
spelling	oai:doaj.org-article:f46e8868c0b7482f8a80622f8b36d9fe2021-12-02T09:40:30ZComparison of the effect of two therapeutic exercises on the inflammatory and physiological conditions and complications of diabetic neuropathy in female patients1178-7007https://doaj.org/article/f46e8868c0b7482f8a80622f8b36d9fe2019-08-01T00:00:00Zhttps://www.dovepress.com/comparison-of-the-effect-of-two-therapeutic-exercises-on-the-inflammat-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Maryam Nadi,1 Effat Bambaeichi,2 Seyyed Mohammad Marandi21Exercise Physiology, University of Isfahan, Isfahan, Iran; 2Faculty of Sport Sciences Department, University of Isfahan, Isfahan, IranCorrespondence: Effat BambaeichiFaculty of Sport Sciences Department, University of Isfahan, Azadi Square, Isfahan 8174673441, IranTel +98 913 205 0472Email e.bambaeichi@yahoo.comIntroduction and aim: The purpose of this study was to compare the effect of 12 weeks of low-intensity resistance training and exercises for peripheral neuropathy (EPN) on the inflammatory and physiological conditions, balance, and complications of diabetic neuropathy in female patients.Materials and methods: 45 women with mild to moderate diabetic neuropathy and an average age of 55.46±3.06 years voluntarily participated in the study. They were randomly assigned to either control (n=15), resistance (n=15), and EPN (n=15) groups. Both experimental groups were trained for 12 weeks (three sessions per week). EPN group did peripheral neuropathic exercises (12 lower extremity movements), and the resistance group performed their exercises with a 30% repetition maximum. During the intervention period, the control group only performed their daily activities. Blood samples were taken in both pre-test and post-test to investigate the levels of Tumor necrosis-α (TNF-α), Interleukin-10 (IL-10), C Reactive Protein (CRP), fast blood glucose (FBG) and Glycated hemoglobin (HbA1c). Complications of diabetic neuropathy were measured using the Michigan questionnaire and the Monofilament 10 g. In order to measure the balance, De Morton mobility index (DEMMI) was used.Results: The statistical analyses showed a significant decrease of FBG and HbA1c in the two experimental groups, as compared to the control group. TNF-α and CRP levels were decreased in both EPN and resistance groups, as compared to the control group. The observed increase in the serum IL-10 levels of the two experimental groups was not, however, significant, as shown in intra-group and inter-group comparisons. On the other hand, the two complications of pain and tingling in the lower limb extremities were improved in both experimental groups (p<0.05). However, the numbness complication showed no significant change (p=0.10). Static and dynamic balance was improved in the EPN group as well (p<0.05).Conclusion: Since EPN exercises, in contrast to resistance exercises, are focused on the lower limb extremities and designed for diabetic neuropathy patients, they can improve the imbalance, pain and tingling, by significantly reducing TNF-α and CRP and improving the physiological conditions.Keywords: TNF-α, IL-10, CRP and diabetic neuropathy exercisesNadi MBambaeichi EMarandi SMDove Medical PressarticleTNF-αIL-10CRP and diabetic neuropathy exercisesSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 1493-1501 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	TNF-α IL-10 CRP and diabetic neuropathy exercises Specialties of internal medicine RC581-951
spellingShingle	TNF-α IL-10 CRP and diabetic neuropathy exercises Specialties of internal medicine RC581-951 Nadi M Bambaeichi E Marandi SM Comparison of the effect of two therapeutic exercises on the inflammatory and physiological conditions and complications of diabetic neuropathy in female patients
description	Maryam Nadi,1 Effat Bambaeichi,2 Seyyed Mohammad Marandi21Exercise Physiology, University of Isfahan, Isfahan, Iran; 2Faculty of Sport Sciences Department, University of Isfahan, Isfahan, IranCorrespondence: Effat BambaeichiFaculty of Sport Sciences Department, University of Isfahan, Azadi Square, Isfahan 8174673441, IranTel +98 913 205 0472Email e.bambaeichi@yahoo.comIntroduction and aim: The purpose of this study was to compare the effect of 12 weeks of low-intensity resistance training and exercises for peripheral neuropathy (EPN) on the inflammatory and physiological conditions, balance, and complications of diabetic neuropathy in female patients.Materials and methods: 45 women with mild to moderate diabetic neuropathy and an average age of 55.46±3.06 years voluntarily participated in the study. They were randomly assigned to either control (n=15), resistance (n=15), and EPN (n=15) groups. Both experimental groups were trained for 12 weeks (three sessions per week). EPN group did peripheral neuropathic exercises (12 lower extremity movements), and the resistance group performed their exercises with a 30% repetition maximum. During the intervention period, the control group only performed their daily activities. Blood samples were taken in both pre-test and post-test to investigate the levels of Tumor necrosis-α (TNF-α), Interleukin-10 (IL-10), C Reactive Protein (CRP), fast blood glucose (FBG) and Glycated hemoglobin (HbA1c). Complications of diabetic neuropathy were measured using the Michigan questionnaire and the Monofilament 10 g. In order to measure the balance, De Morton mobility index (DEMMI) was used.Results: The statistical analyses showed a significant decrease of FBG and HbA1c in the two experimental groups, as compared to the control group. TNF-α and CRP levels were decreased in both EPN and resistance groups, as compared to the control group. The observed increase in the serum IL-10 levels of the two experimental groups was not, however, significant, as shown in intra-group and inter-group comparisons. On the other hand, the two complications of pain and tingling in the lower limb extremities were improved in both experimental groups (p<0.05). However, the numbness complication showed no significant change (p=0.10). Static and dynamic balance was improved in the EPN group as well (p<0.05).Conclusion: Since EPN exercises, in contrast to resistance exercises, are focused on the lower limb extremities and designed for diabetic neuropathy patients, they can improve the imbalance, pain and tingling, by significantly reducing TNF-α and CRP and improving the physiological conditions.Keywords: TNF-α, IL-10, CRP and diabetic neuropathy exercises
format	article
author	Nadi M Bambaeichi E Marandi SM
author_facet	Nadi M Bambaeichi E Marandi SM
author_sort	Nadi M
title	Comparison of the effect of two therapeutic exercises on the inflammatory and physiological conditions and complications of diabetic neuropathy in female patients
title_short	Comparison of the effect of two therapeutic exercises on the inflammatory and physiological conditions and complications of diabetic neuropathy in female patients
title_full	Comparison of the effect of two therapeutic exercises on the inflammatory and physiological conditions and complications of diabetic neuropathy in female patients
title_fullStr	Comparison of the effect of two therapeutic exercises on the inflammatory and physiological conditions and complications of diabetic neuropathy in female patients
title_full_unstemmed	Comparison of the effect of two therapeutic exercises on the inflammatory and physiological conditions and complications of diabetic neuropathy in female patients
title_sort	comparison of the effect of two therapeutic exercises on the inflammatory and physiological conditions and complications of diabetic neuropathy in female patients
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/f46e8868c0b7482f8a80622f8b36d9fe
work_keys_str_mv	AT nadim comparisonoftheeffectoftwotherapeuticexercisesontheinflammatoryandphysiologicalconditionsandcomplicationsofdiabeticneuropathyinfemalepatients AT bambaeichie comparisonoftheeffectoftwotherapeuticexercisesontheinflammatoryandphysiologicalconditionsandcomplicationsofdiabeticneuropathyinfemalepatients AT marandism comparisonoftheeffectoftwotherapeuticexercisesontheinflammatoryandphysiologicalconditionsandcomplicationsofdiabeticneuropathyinfemalepatients
_version_	1718398098919653376

Comparison of the effect of two therapeutic exercises on the inflammatory and physiological conditions and complications of diabetic neuropathy in female patients

Ejemplares similares