Reactive oxygen species (ROS)-responsive nanoprobe for bioimaging and targeting therapy of osteoarthritis

Abstract Stimulus-responsive therapy that allows precise imaging-guided therapy is limited for osteoarthritis (OA) therapy due to the selection of proper physiological markers as stimulus. Based on that the over-production of Reactive Oxygen Species (ROS) is associated with the progression in OA, we...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chong Shen, Ming Gao, Haimin Chen, Yanting Zhan, Qiumei Lan, Zhimin Li, Wei Xiong, Zainen Qin, Li Zheng, Jinmin Zhao
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	ROS-responsive Drug delivery Targeting therapy Osteoarthritis Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/f475fa47d5db40e5951920de540a53d6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f475fa47d5db40e5951920de540a53d6
record_format	dspace
spelling	oai:doaj.org-article:f475fa47d5db40e5951920de540a53d62021-11-28T12:26:45ZReactive oxygen species (ROS)-responsive nanoprobe for bioimaging and targeting therapy of osteoarthritis10.1186/s12951-021-01136-41477-3155https://doaj.org/article/f475fa47d5db40e5951920de540a53d62021-11-01T00:00:00Zhttps://doi.org/10.1186/s12951-021-01136-4https://doaj.org/toc/1477-3155Abstract Stimulus-responsive therapy that allows precise imaging-guided therapy is limited for osteoarthritis (OA) therapy due to the selection of proper physiological markers as stimulus. Based on that the over-production of Reactive Oxygen Species (ROS) is associated with the progression in OA, we selected ROS as markers and designed a cartilage targeting and ROS-responsive theranostic nanoprobe that can be used for effective bioimaging and therapy of OA. This nanoprobe was fabricated by using PEG micelles modified with ROS-sensitive thioketal linkers (TK) and cartilage-targeting peptide, termed TKCP, which was then encapsulated with Dexamethasone (DEX) to form TKCP@DEX nanoparticles. Results showed that the nanoprobe can smartly “turn on” in response to excessive ROS and “turn off” in the normal joint. By applying different doses of ROS inducer and ROS inhibitor, this nanoprobe can emit ROS-dependent fluorescence according to the degree of OA severity, helpful to precise disease classification in clinic. Specifically targeting cartilage, TKCP@DEX could effectively respond to ROS and sustained release DEX to remarkably reduce cartilage damage in the OA joints. This smart, sensitive and endogenously activated ROS-responsive nanoprobe is promising for OA theranostics. Graphical AbstractChong ShenMing GaoHaimin ChenYanting ZhanQiumei LanZhimin LiWei XiongZainen QinLi ZhengJinmin ZhaoBMCarticleROS-responsiveDrug deliveryTargeting therapyOsteoarthritisBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENJournal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ROS-responsive Drug delivery Targeting therapy Osteoarthritis Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	ROS-responsive Drug delivery Targeting therapy Osteoarthritis Biotechnology TP248.13-248.65 Medical technology R855-855.5 Chong Shen Ming Gao Haimin Chen Yanting Zhan Qiumei Lan Zhimin Li Wei Xiong Zainen Qin Li Zheng Jinmin Zhao Reactive oxygen species (ROS)-responsive nanoprobe for bioimaging and targeting therapy of osteoarthritis
description	Abstract Stimulus-responsive therapy that allows precise imaging-guided therapy is limited for osteoarthritis (OA) therapy due to the selection of proper physiological markers as stimulus. Based on that the over-production of Reactive Oxygen Species (ROS) is associated with the progression in OA, we selected ROS as markers and designed a cartilage targeting and ROS-responsive theranostic nanoprobe that can be used for effective bioimaging and therapy of OA. This nanoprobe was fabricated by using PEG micelles modified with ROS-sensitive thioketal linkers (TK) and cartilage-targeting peptide, termed TKCP, which was then encapsulated with Dexamethasone (DEX) to form TKCP@DEX nanoparticles. Results showed that the nanoprobe can smartly “turn on” in response to excessive ROS and “turn off” in the normal joint. By applying different doses of ROS inducer and ROS inhibitor, this nanoprobe can emit ROS-dependent fluorescence according to the degree of OA severity, helpful to precise disease classification in clinic. Specifically targeting cartilage, TKCP@DEX could effectively respond to ROS and sustained release DEX to remarkably reduce cartilage damage in the OA joints. This smart, sensitive and endogenously activated ROS-responsive nanoprobe is promising for OA theranostics. Graphical Abstract
format	article
author	Chong Shen Ming Gao Haimin Chen Yanting Zhan Qiumei Lan Zhimin Li Wei Xiong Zainen Qin Li Zheng Jinmin Zhao
author_facet	Chong Shen Ming Gao Haimin Chen Yanting Zhan Qiumei Lan Zhimin Li Wei Xiong Zainen Qin Li Zheng Jinmin Zhao
author_sort	Chong Shen
title	Reactive oxygen species (ROS)-responsive nanoprobe for bioimaging and targeting therapy of osteoarthritis
title_short	Reactive oxygen species (ROS)-responsive nanoprobe for bioimaging and targeting therapy of osteoarthritis
title_full	Reactive oxygen species (ROS)-responsive nanoprobe for bioimaging and targeting therapy of osteoarthritis
title_fullStr	Reactive oxygen species (ROS)-responsive nanoprobe for bioimaging and targeting therapy of osteoarthritis
title_full_unstemmed	Reactive oxygen species (ROS)-responsive nanoprobe for bioimaging and targeting therapy of osteoarthritis
title_sort	reactive oxygen species (ros)-responsive nanoprobe for bioimaging and targeting therapy of osteoarthritis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/f475fa47d5db40e5951920de540a53d6
work_keys_str_mv	AT chongshen reactiveoxygenspeciesrosresponsivenanoprobeforbioimagingandtargetingtherapyofosteoarthritis AT minggao reactiveoxygenspeciesrosresponsivenanoprobeforbioimagingandtargetingtherapyofosteoarthritis AT haiminchen reactiveoxygenspeciesrosresponsivenanoprobeforbioimagingandtargetingtherapyofosteoarthritis AT yantingzhan reactiveoxygenspeciesrosresponsivenanoprobeforbioimagingandtargetingtherapyofosteoarthritis AT qiumeilan reactiveoxygenspeciesrosresponsivenanoprobeforbioimagingandtargetingtherapyofosteoarthritis AT zhiminli reactiveoxygenspeciesrosresponsivenanoprobeforbioimagingandtargetingtherapyofosteoarthritis AT weixiong reactiveoxygenspeciesrosresponsivenanoprobeforbioimagingandtargetingtherapyofosteoarthritis AT zainenqin reactiveoxygenspeciesrosresponsivenanoprobeforbioimagingandtargetingtherapyofosteoarthritis AT lizheng reactiveoxygenspeciesrosresponsivenanoprobeforbioimagingandtargetingtherapyofosteoarthritis AT jinminzhao reactiveoxygenspeciesrosresponsivenanoprobeforbioimagingandtargetingtherapyofosteoarthritis
_version_	1718407990570123264

Reactive oxygen species (ROS)-responsive nanoprobe for bioimaging and targeting therapy of osteoarthritis

Ejemplares similares