The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus

Mutations in the MLL4 gene can cause Kabuki syndrome, whose underlying molecular mechanisms are unclear. Here, the authors show that Mll4 epigenetically regulates the transcriptional program leading to the formation of GHRH-neurons in the developing mouse hypothalamus.

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Autores principales:	Christian Huisman, Young A. Kim, Shin Jeon, Bongjin Shin, Jeonghoon Choi, Su Jeong Lim, Sung Min Youn, Younjung Park, Medha K. C., Sangsoo Kim, Soo-Kyung Lee, Seunghee Lee, Jae W. Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f4776337d0c9432e83c1b590c0f4a473
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spelling	oai:doaj.org-article:f4776337d0c9432e83c1b590c0f4a4732021-12-02T14:12:04ZThe histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus10.1038/s41467-020-20511-72041-1723https://doaj.org/article/f4776337d0c9432e83c1b590c0f4a4732021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20511-7https://doaj.org/toc/2041-1723Mutations in the MLL4 gene can cause Kabuki syndrome, whose underlying molecular mechanisms are unclear. Here, the authors show that Mll4 epigenetically regulates the transcriptional program leading to the formation of GHRH-neurons in the developing mouse hypothalamus.Christian HuismanYoung A. KimShin JeonBongjin ShinJeonghoon ChoiSu Jeong LimSung Min YounYounjung ParkMedha K. C.Sangsoo KimSoo-Kyung LeeSeunghee LeeJae W. LeeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christian Huisman Young A. Kim Shin Jeon Bongjin Shin Jeonghoon Choi Su Jeong Lim Sung Min Youn Younjung Park Medha K. C. Sangsoo Kim Soo-Kyung Lee Seunghee Lee Jae W. Lee The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus
description	Mutations in the MLL4 gene can cause Kabuki syndrome, whose underlying molecular mechanisms are unclear. Here, the authors show that Mll4 epigenetically regulates the transcriptional program leading to the formation of GHRH-neurons in the developing mouse hypothalamus.
format	article
author	Christian Huisman Young A. Kim Shin Jeon Bongjin Shin Jeonghoon Choi Su Jeong Lim Sung Min Youn Younjung Park Medha K. C. Sangsoo Kim Soo-Kyung Lee Seunghee Lee Jae W. Lee
author_facet	Christian Huisman Young A. Kim Shin Jeon Bongjin Shin Jeonghoon Choi Su Jeong Lim Sung Min Youn Younjung Park Medha K. C. Sangsoo Kim Soo-Kyung Lee Seunghee Lee Jae W. Lee
author_sort	Christian Huisman
title	The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus
title_short	The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus
title_full	The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus
title_fullStr	The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus
title_full_unstemmed	The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus
title_sort	histone h3-lysine 4-methyltransferase mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f4776337d0c9432e83c1b590c0f4a473
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The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus

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