The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus

The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus

Mutations in the MLL4 gene can cause Kabuki syndrome, whose underlying molecular mechanisms are unclear. Here, the authors show that Mll4 epigenetically regulates the transcriptional program leading to the formation of GHRH-neurons in the developing mouse hypothalamus.

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Detalles Bibliográficos
Autores principales: Christian Huisman, Young A. Kim, Shin Jeon, Bongjin Shin, Jeonghoon Choi, Su Jeong Lim, Sung Min Youn, Younjung Park, Medha K. C., Sangsoo Kim, Soo-Kyung Lee, Seunghee Lee, Jae W. Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/f4776337d0c9432e83c1b590c0f4a473
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