Deep mutational scanning of the plasminogen activator inhibitor-1 functional landscape

Deep mutational scanning of the plasminogen activator inhibitor-1 functional landscape

Abstract The serine protease inhibitor (SERPIN) plasminogen activator inhibitor-1 (PAI-1) is a key regulator of the fibrinolytic system, inhibiting the serine proteases tissue- and urokinase-type plasminogen activator (tPA and uPA, respectively). Missense variants render PAI-1 non-functional through...

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Autores principales: Zachary M. Huttinger, Laura M. Haynes, Andrew Yee, Colin A. Kretz, Matthew L. Holding, David R. Siemieniak, Daniel A. Lawrence, David Ginsburg
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
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Science
Q
Acceso en línea:https://doaj.org/article/f47950a71a2243e4bed673bbf54e9f40
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