Structural and Functional Characterization of OXA-48: Insight into Mechanism and Structural Basis of Substrate Recognition and Specificity

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Structural and Functional Characterization of OXA-48: Insight into Mechanism and Structural Basis of Substrate Recognition and Specificity

Class D β-lactamase OXA-48 is widely distributed among Gram-negative bacteria and is an important determinant of resistance to the last-resort carbapenems. Nevertheless, the detailed mechanism by which this β-lactamase hydrolyzes its substrates remains poorly understood. In this study, the complex s...

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Autores principales:	Jiachi Chiou, Qipeng Cheng, Perry Tim-fat Shum, Marcus Ho-yin Wong, Edward Wai-chi Chan, Sheng Chen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	carbapenemase OXA-48 active site residues interaction β-lactams Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f47b3272ce3a49a29acb1e096c33c58c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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