Alterations of oral microbiota distinguish children with autism spectrum disorders from healthy controls

Abstract Altered gut microbiota is associated with autism spectrum disorders (ASD), a group of complex, fast growing but difficult-to-diagnose neurodevelopmental disorders worldwide. However, the role of the oral microbiota in ASD remains unexplored. Via high-throughput sequencing of 111 oral sample...

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Autores principales:	Yanan Qiao, Mingtao Wu, Yanhuizhi Feng, Zhichong Zhou, Lei Chen, Fengshan Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f48079b2f8b14afaa73b3bf478c255c3
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spelling	oai:doaj.org-article:f48079b2f8b14afaa73b3bf478c255c32021-12-02T15:08:50ZAlterations of oral microbiota distinguish children with autism spectrum disorders from healthy controls10.1038/s41598-018-19982-y2045-2322https://doaj.org/article/f48079b2f8b14afaa73b3bf478c255c32018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19982-yhttps://doaj.org/toc/2045-2322Abstract Altered gut microbiota is associated with autism spectrum disorders (ASD), a group of complex, fast growing but difficult-to-diagnose neurodevelopmental disorders worldwide. However, the role of the oral microbiota in ASD remains unexplored. Via high-throughput sequencing of 111 oral samples in 32 children with ASD and 27 healthy controls, we demonstrated that the salivary and dental microbiota of ASD patients were highly distinct from those of healthy individuals. Lower bacterial diversity was observed in ASD children compared to controls, especially in dental samples. Also, principal coordinate analysis revealed divergences between ASD patients and controls. Moreover, pathogens such as Haemophilus in saliva and Streptococcus in plaques showed significantly higher abundance in ASD patients, whereas commensals such as Prevotella, Selenomonas, Actinomyces, Porphyromonas, and Fusobacterium were reduced. Specifically, an overt depletion of Prevotellaceae co-occurrence network in ASD patients was obtained in dental plaques. The distinguishable bacteria were also correlated with clinical indices, reflecting disease severity and the oral health status (i.e. dental caries). Finally, diagnostic models based on key microbes were constructed, with 96.3% accuracy in saliva. Taken together, this study characterized the habitat-specific profile of the oral microbiota in ASD patients, which might help develop novel strategies for the diagnosis of ASD.Yanan QiaoMingtao WuYanhuizhi FengZhichong ZhouLei ChenFengshan ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yanan Qiao Mingtao Wu Yanhuizhi Feng Zhichong Zhou Lei Chen Fengshan Chen Alterations of oral microbiota distinguish children with autism spectrum disorders from healthy controls
description	Abstract Altered gut microbiota is associated with autism spectrum disorders (ASD), a group of complex, fast growing but difficult-to-diagnose neurodevelopmental disorders worldwide. However, the role of the oral microbiota in ASD remains unexplored. Via high-throughput sequencing of 111 oral samples in 32 children with ASD and 27 healthy controls, we demonstrated that the salivary and dental microbiota of ASD patients were highly distinct from those of healthy individuals. Lower bacterial diversity was observed in ASD children compared to controls, especially in dental samples. Also, principal coordinate analysis revealed divergences between ASD patients and controls. Moreover, pathogens such as Haemophilus in saliva and Streptococcus in plaques showed significantly higher abundance in ASD patients, whereas commensals such as Prevotella, Selenomonas, Actinomyces, Porphyromonas, and Fusobacterium were reduced. Specifically, an overt depletion of Prevotellaceae co-occurrence network in ASD patients was obtained in dental plaques. The distinguishable bacteria were also correlated with clinical indices, reflecting disease severity and the oral health status (i.e. dental caries). Finally, diagnostic models based on key microbes were constructed, with 96.3% accuracy in saliva. Taken together, this study characterized the habitat-specific profile of the oral microbiota in ASD patients, which might help develop novel strategies for the diagnosis of ASD.
format	article
author	Yanan Qiao Mingtao Wu Yanhuizhi Feng Zhichong Zhou Lei Chen Fengshan Chen
author_facet	Yanan Qiao Mingtao Wu Yanhuizhi Feng Zhichong Zhou Lei Chen Fengshan Chen
author_sort	Yanan Qiao
title	Alterations of oral microbiota distinguish children with autism spectrum disorders from healthy controls
title_short	Alterations of oral microbiota distinguish children with autism spectrum disorders from healthy controls
title_full	Alterations of oral microbiota distinguish children with autism spectrum disorders from healthy controls
title_fullStr	Alterations of oral microbiota distinguish children with autism spectrum disorders from healthy controls
title_full_unstemmed	Alterations of oral microbiota distinguish children with autism spectrum disorders from healthy controls
title_sort	alterations of oral microbiota distinguish children with autism spectrum disorders from healthy controls
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f48079b2f8b14afaa73b3bf478c255c3
work_keys_str_mv	AT yananqiao alterationsoforalmicrobiotadistinguishchildrenwithautismspectrumdisordersfromhealthycontrols AT mingtaowu alterationsoforalmicrobiotadistinguishchildrenwithautismspectrumdisordersfromhealthycontrols AT yanhuizhifeng alterationsoforalmicrobiotadistinguishchildrenwithautismspectrumdisordersfromhealthycontrols AT zhichongzhou alterationsoforalmicrobiotadistinguishchildrenwithautismspectrumdisordersfromhealthycontrols AT leichen alterationsoforalmicrobiotadistinguishchildrenwithautismspectrumdisordersfromhealthycontrols AT fengshanchen alterationsoforalmicrobiotadistinguishchildrenwithautismspectrumdisordersfromhealthycontrols
_version_	1718388036710957056

Alterations of oral microbiota distinguish children with autism spectrum disorders from healthy controls

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