Plasma and erythrocyte fatty acid patterns in patients with recurrent depression: a matched case-control study.

<h4>Background</h4>The polyunsaturated fatty acid (PUFA) composition of (nerve) cell membranes may be involved in the pathophysiology of depression. Studies so far, focussed mainly on omega-3 and omega-6 PUFAs. In the present study, saturated fatty acids (SFAs), monounsaturated fatty aci...

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Autores principales:	Johanna Assies, François Pouwer, Anja Lok, Roel J T Mocking, Claudi L H Bockting, Ieke Visser, Nico G G M Abeling, Marinus Duran, Aart H Schene
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f480c19ee65d41d4b55620da350f670c
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spelling	oai:doaj.org-article:f480c19ee65d41d4b55620da350f670c2021-12-02T20:21:40ZPlasma and erythrocyte fatty acid patterns in patients with recurrent depression: a matched case-control study.1932-620310.1371/journal.pone.0010635https://doaj.org/article/f480c19ee65d41d4b55620da350f670c2010-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20498721/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The polyunsaturated fatty acid (PUFA) composition of (nerve) cell membranes may be involved in the pathophysiology of depression. Studies so far, focussed mainly on omega-3 and omega-6 PUFAs. In the present study, saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) and PUFAs of the omega-3, -6 and -9 series in plasma and erythrocytes of patients with recurrent major depressive disorder (MDD-R) were compared with controls.<h4>Methodology and principal findings</h4>We carried out a case-control study. The sample consisted of 137 patients with MDD-R and 65 matched non-depressed controls. In plasma and erythrocytes of patients with MDD-R the concentrations of most of the SFAs and MUFAs, and additionally erythrocyte PUFAs, all with a chain length > 20 carbon (C) atoms, were significantly lower than in the controls. In contrast, the concentrations of most of the shorter chain members (< or = 18C) of the SFAs and MUFAs were significantly higher in the patients. Estimated activities of several elongases in plasma of patients were significantly altered, whereas delta-9 desaturase activity for C14:0 and C18:0 was significantly higher.<h4>Conclusions/significance</h4>The fatty acid status of patients with MDD-R not only differs with regard to omega-3 and omega-6 PUFAs, but also concerns other fatty acids. These alterations may be due to: differences in diet, changes in synthesizing enzyme activities, higher levels of chronic (oxidative) stress but may also result from adaptive strategies by providing protection against enhanced oxidative stress and production of free radicals.Johanna AssiesFrançois PouwerAnja LokRoel J T MockingClaudi L H BocktingIeke VisserNico G G M AbelingMarinus DuranAart H SchenePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 5, p e10635 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Johanna Assies François Pouwer Anja Lok Roel J T Mocking Claudi L H Bockting Ieke Visser Nico G G M Abeling Marinus Duran Aart H Schene Plasma and erythrocyte fatty acid patterns in patients with recurrent depression: a matched case-control study.
description	<h4>Background</h4>The polyunsaturated fatty acid (PUFA) composition of (nerve) cell membranes may be involved in the pathophysiology of depression. Studies so far, focussed mainly on omega-3 and omega-6 PUFAs. In the present study, saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) and PUFAs of the omega-3, -6 and -9 series in plasma and erythrocytes of patients with recurrent major depressive disorder (MDD-R) were compared with controls.<h4>Methodology and principal findings</h4>We carried out a case-control study. The sample consisted of 137 patients with MDD-R and 65 matched non-depressed controls. In plasma and erythrocytes of patients with MDD-R the concentrations of most of the SFAs and MUFAs, and additionally erythrocyte PUFAs, all with a chain length > 20 carbon (C) atoms, were significantly lower than in the controls. In contrast, the concentrations of most of the shorter chain members (< or = 18C) of the SFAs and MUFAs were significantly higher in the patients. Estimated activities of several elongases in plasma of patients were significantly altered, whereas delta-9 desaturase activity for C14:0 and C18:0 was significantly higher.<h4>Conclusions/significance</h4>The fatty acid status of patients with MDD-R not only differs with regard to omega-3 and omega-6 PUFAs, but also concerns other fatty acids. These alterations may be due to: differences in diet, changes in synthesizing enzyme activities, higher levels of chronic (oxidative) stress but may also result from adaptive strategies by providing protection against enhanced oxidative stress and production of free radicals.
format	article
author	Johanna Assies François Pouwer Anja Lok Roel J T Mocking Claudi L H Bockting Ieke Visser Nico G G M Abeling Marinus Duran Aart H Schene
author_facet	Johanna Assies François Pouwer Anja Lok Roel J T Mocking Claudi L H Bockting Ieke Visser Nico G G M Abeling Marinus Duran Aart H Schene
author_sort	Johanna Assies
title	Plasma and erythrocyte fatty acid patterns in patients with recurrent depression: a matched case-control study.
title_short	Plasma and erythrocyte fatty acid patterns in patients with recurrent depression: a matched case-control study.
title_full	Plasma and erythrocyte fatty acid patterns in patients with recurrent depression: a matched case-control study.
title_fullStr	Plasma and erythrocyte fatty acid patterns in patients with recurrent depression: a matched case-control study.
title_full_unstemmed	Plasma and erythrocyte fatty acid patterns in patients with recurrent depression: a matched case-control study.
title_sort	plasma and erythrocyte fatty acid patterns in patients with recurrent depression: a matched case-control study.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/f480c19ee65d41d4b55620da350f670c
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Plasma and erythrocyte fatty acid patterns in patients with recurrent depression: a matched case-control study.

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