DNA methylation in mice is influenced by genetics as well as sex and life experience

DNA methylation is an epigenetic mark involved in gene regulation. Here the authors investigate the extent to which genetics, sex and pregnancy influence genomic DNA methylation in mice, providing evidence of the stability of CpG methylation across generation and suggest that CpG methylation may ser...

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Autores principales:	Sara A. Grimm, Takashi Shimbo, Motoki Takaku, James W. Thomas, Scott Auerbach, Brian D. Bennett, John R. Bucher, Adam B. Burkholder, Frank Day, Ying Du, Christopher G. Duncan, John E. French, Julie F. Foley, Jianying Li, B. Alex Merrick, Raymond R. Tice, Tianyuan Wang, Xiaojiang Xu, NISC Comparative Sequencing Program, Pierre R. Bushel, David C. Fargo, James C. Mullikin, Paul A. Wade
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f487b8a5e96d4b4596531537eeed2656
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spelling	oai:doaj.org-article:f487b8a5e96d4b4596531537eeed26562021-12-02T14:38:41ZDNA methylation in mice is influenced by genetics as well as sex and life experience10.1038/s41467-018-08067-z2041-1723https://doaj.org/article/f487b8a5e96d4b4596531537eeed26562019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08067-zhttps://doaj.org/toc/2041-1723DNA methylation is an epigenetic mark involved in gene regulation. Here the authors investigate the extent to which genetics, sex and pregnancy influence genomic DNA methylation in mice, providing evidence of the stability of CpG methylation across generation and suggest that CpG methylation may serve as an epigenetic record of life events in somatic tissues at loci whose expression is linked to the relevant biology.Sara A. GrimmTakashi ShimboMotoki TakakuJames W. ThomasScott AuerbachBrian D. BennettJohn R. BucherAdam B. BurkholderFrank DayYing DuChristopher G. DuncanJohn E. FrenchJulie F. FoleyJianying LiB. Alex MerrickRaymond R. TiceTianyuan WangXiaojiang XuNISC Comparative Sequencing ProgramPierre R. BushelDavid C. FargoJames C. MullikinPaul A. WadeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sara A. Grimm Takashi Shimbo Motoki Takaku James W. Thomas Scott Auerbach Brian D. Bennett John R. Bucher Adam B. Burkholder Frank Day Ying Du Christopher G. Duncan John E. French Julie F. Foley Jianying Li B. Alex Merrick Raymond R. Tice Tianyuan Wang Xiaojiang Xu NISC Comparative Sequencing Program Pierre R. Bushel David C. Fargo James C. Mullikin Paul A. Wade DNA methylation in mice is influenced by genetics as well as sex and life experience
description	DNA methylation is an epigenetic mark involved in gene regulation. Here the authors investigate the extent to which genetics, sex and pregnancy influence genomic DNA methylation in mice, providing evidence of the stability of CpG methylation across generation and suggest that CpG methylation may serve as an epigenetic record of life events in somatic tissues at loci whose expression is linked to the relevant biology.
format	article
author	Sara A. Grimm Takashi Shimbo Motoki Takaku James W. Thomas Scott Auerbach Brian D. Bennett John R. Bucher Adam B. Burkholder Frank Day Ying Du Christopher G. Duncan John E. French Julie F. Foley Jianying Li B. Alex Merrick Raymond R. Tice Tianyuan Wang Xiaojiang Xu NISC Comparative Sequencing Program Pierre R. Bushel David C. Fargo James C. Mullikin Paul A. Wade
author_facet	Sara A. Grimm Takashi Shimbo Motoki Takaku James W. Thomas Scott Auerbach Brian D. Bennett John R. Bucher Adam B. Burkholder Frank Day Ying Du Christopher G. Duncan John E. French Julie F. Foley Jianying Li B. Alex Merrick Raymond R. Tice Tianyuan Wang Xiaojiang Xu NISC Comparative Sequencing Program Pierre R. Bushel David C. Fargo James C. Mullikin Paul A. Wade
author_sort	Sara A. Grimm
title	DNA methylation in mice is influenced by genetics as well as sex and life experience
title_short	DNA methylation in mice is influenced by genetics as well as sex and life experience
title_full	DNA methylation in mice is influenced by genetics as well as sex and life experience
title_fullStr	DNA methylation in mice is influenced by genetics as well as sex and life experience
title_full_unstemmed	DNA methylation in mice is influenced by genetics as well as sex and life experience
title_sort	dna methylation in mice is influenced by genetics as well as sex and life experience
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f487b8a5e96d4b4596531537eeed2656
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DNA methylation in mice is influenced by genetics as well as sex and life experience

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