Relative Contributions of Prenylation and Postprenylation Processing in <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Pathogenesis

Relative Contributions of Prenylation and Postprenylation Processing in <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Pathogenesis

ABSTRACT Prenyltransferase enzymes promote the membrane localization of their target proteins by directing the attachment of a hydrophobic lipid group at a conserved C-terminal CAAX motif. Subsequently, the prenylated protein is further modified by postprenylation processing enzymes that cleave the...

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Bibliographic Details
Main Authors: Shannon K. Esher, Kyla S. Ost, Lukasz Kozubowski, Dong-Hoon Yang, Min Su Kim, Yong-Sun Bahn, J. Andrew Alspaugh, Connie B. Nichols
Format: article
Language:EN
Published: American Society for Microbiology 2016
Subjects:
Cryptococcus neoformans
farnesyltransferase
fungal pathogen
protein prenylation
Ras-like GTPases
Microbiology
QR1-502
Online Access:https://doaj.org/article/f4899708ff68499aa223282fe1165f78
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https://doaj.org/article/f4899708ff68499aa223282fe1165f78

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