Chromatin-accessibility estimation from single-cell ATAC-seq data with scOpen
scATAC-Seq yields data that is extremely sparse. Here, the authors present a computationally efficient imputation method called scOpen that improves the downstream analyses of scATAC-Seq data and use it to identify transcriptional regulators of kidney fibrosis.
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Nature Portfolio
2021
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oai:doaj.org-article:f489d02ade954c108604ac36561468ad2021-11-08T11:09:09ZChromatin-accessibility estimation from single-cell ATAC-seq data with scOpen10.1038/s41467-021-26530-22041-1723https://doaj.org/article/f489d02ade954c108604ac36561468ad2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26530-2https://doaj.org/toc/2041-1723scATAC-Seq yields data that is extremely sparse. Here, the authors present a computationally efficient imputation method called scOpen that improves the downstream analyses of scATAC-Seq data and use it to identify transcriptional regulators of kidney fibrosis.Zhijian LiChristoph KuppeSusanne ZieglerMingbo ChengNazanin KabganiSylvia MenzelMartin ZenkeRafael KramannIvan G. CostaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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Science Q Zhijian Li Christoph Kuppe Susanne Ziegler Mingbo Cheng Nazanin Kabgani Sylvia Menzel Martin Zenke Rafael Kramann Ivan G. Costa Chromatin-accessibility estimation from single-cell ATAC-seq data with scOpen |
description |
scATAC-Seq yields data that is extremely sparse. Here, the authors present a computationally efficient imputation method called scOpen that improves the downstream analyses of scATAC-Seq data and use it to identify transcriptional regulators of kidney fibrosis. |
format |
article |
author |
Zhijian Li Christoph Kuppe Susanne Ziegler Mingbo Cheng Nazanin Kabgani Sylvia Menzel Martin Zenke Rafael Kramann Ivan G. Costa |
author_facet |
Zhijian Li Christoph Kuppe Susanne Ziegler Mingbo Cheng Nazanin Kabgani Sylvia Menzel Martin Zenke Rafael Kramann Ivan G. Costa |
author_sort |
Zhijian Li |
title |
Chromatin-accessibility estimation from single-cell ATAC-seq data with scOpen |
title_short |
Chromatin-accessibility estimation from single-cell ATAC-seq data with scOpen |
title_full |
Chromatin-accessibility estimation from single-cell ATAC-seq data with scOpen |
title_fullStr |
Chromatin-accessibility estimation from single-cell ATAC-seq data with scOpen |
title_full_unstemmed |
Chromatin-accessibility estimation from single-cell ATAC-seq data with scOpen |
title_sort |
chromatin-accessibility estimation from single-cell atac-seq data with scopen |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/f489d02ade954c108604ac36561468ad |
work_keys_str_mv |
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1718442390388211712 |