Chromatin-accessibility estimation from single-cell ATAC-seq data with scOpen

Chromatin-accessibility estimation from single-cell ATAC-seq data with scOpen

scATAC-Seq yields data that is extremely sparse. Here, the authors present a computationally efficient imputation method called scOpen that improves the downstream analyses of scATAC-Seq data and use it to identify transcriptional regulators of kidney fibrosis.

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Detalles Bibliográficos
Autores principales: Zhijian Li, Christoph Kuppe, Susanne Ziegler, Mingbo Cheng, Nazanin Kabgani, Sylvia Menzel, Martin Zenke, Rafael Kramann, Ivan G. Costa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/f489d02ade954c108604ac36561468ad
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