Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection

The inorganic procoagulant polymer polyphosphate participates in thrombosis via factor XII. Here the authors use recombinant probes that specifically bind or degrade circulating polyphosphate to protect mice in arterial and venous thrombosis models without an increased bleeding risk, the primary com...

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Autores principales:	Linda Labberton, Ellinor Kenne, Andy T. Long, Katrin F. Nickel, Antonio Di Gennaro, Rachel A. Rigg, James S. Hernandez, Lynn Butler, Coen Maas, Evi X. Stavrou, Thomas Renné
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f48adfdce9824e40bf17559630815825
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spelling	oai:doaj.org-article:f48adfdce9824e40bf175596308158252021-12-02T15:35:24ZNeutralizing blood-borne polyphosphate in vivo provides safe thromboprotection10.1038/ncomms126162041-1723https://doaj.org/article/f48adfdce9824e40bf175596308158252016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12616https://doaj.org/toc/2041-1723The inorganic procoagulant polymer polyphosphate participates in thrombosis via factor XII. Here the authors use recombinant probes that specifically bind or degrade circulating polyphosphate to protect mice in arterial and venous thrombosis models without an increased bleeding risk, the primary complication of all currently used anticoagulants.Linda LabbertonEllinor KenneAndy T. LongKatrin F. NickelAntonio Di GennaroRachel A. RiggJames S. HernandezLynn ButlerCoen MaasEvi X. StavrouThomas RennéNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Linda Labberton Ellinor Kenne Andy T. Long Katrin F. Nickel Antonio Di Gennaro Rachel A. Rigg James S. Hernandez Lynn Butler Coen Maas Evi X. Stavrou Thomas Renné Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection
description	The inorganic procoagulant polymer polyphosphate participates in thrombosis via factor XII. Here the authors use recombinant probes that specifically bind or degrade circulating polyphosphate to protect mice in arterial and venous thrombosis models without an increased bleeding risk, the primary complication of all currently used anticoagulants.
format	article
author	Linda Labberton Ellinor Kenne Andy T. Long Katrin F. Nickel Antonio Di Gennaro Rachel A. Rigg James S. Hernandez Lynn Butler Coen Maas Evi X. Stavrou Thomas Renné
author_facet	Linda Labberton Ellinor Kenne Andy T. Long Katrin F. Nickel Antonio Di Gennaro Rachel A. Rigg James S. Hernandez Lynn Butler Coen Maas Evi X. Stavrou Thomas Renné
author_sort	Linda Labberton
title	Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection
title_short	Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection
title_full	Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection
title_fullStr	Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection
title_full_unstemmed	Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection
title_sort	neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f48adfdce9824e40bf17559630815825
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Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection

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