High-resolution TADs reveal DNA sequences underlying genome organization in flies

Although topologically associating domains (TADs) have been extensively investigated, it is not clear to what extent DNA sequence contributes to their formation. Here the authors develop software to identify high-resolution TAD boundaries and reveal their relationship to underlying DNA motifs.

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Autores principales:	Fidel Ramírez, Vivek Bhardwaj, Laura Arrigoni, Kin Chung Lam, Björn A. Grüning, José Villaveces, Bianca Habermann, Asifa Akhtar, Thomas Manke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f48cef696c874fc680f5d90d7c13d700
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spelling	oai:doaj.org-article:f48cef696c874fc680f5d90d7c13d7002021-12-02T16:49:38ZHigh-resolution TADs reveal DNA sequences underlying genome organization in flies10.1038/s41467-017-02525-w2041-1723https://doaj.org/article/f48cef696c874fc680f5d90d7c13d7002018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02525-whttps://doaj.org/toc/2041-1723Although topologically associating domains (TADs) have been extensively investigated, it is not clear to what extent DNA sequence contributes to their formation. Here the authors develop software to identify high-resolution TAD boundaries and reveal their relationship to underlying DNA motifs.Fidel RamírezVivek BhardwajLaura ArrigoniKin Chung LamBjörn A. GrüningJosé VillavecesBianca HabermannAsifa AkhtarThomas MankeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fidel Ramírez Vivek Bhardwaj Laura Arrigoni Kin Chung Lam Björn A. Grüning José Villaveces Bianca Habermann Asifa Akhtar Thomas Manke High-resolution TADs reveal DNA sequences underlying genome organization in flies
description	Although topologically associating domains (TADs) have been extensively investigated, it is not clear to what extent DNA sequence contributes to their formation. Here the authors develop software to identify high-resolution TAD boundaries and reveal their relationship to underlying DNA motifs.
format	article
author	Fidel Ramírez Vivek Bhardwaj Laura Arrigoni Kin Chung Lam Björn A. Grüning José Villaveces Bianca Habermann Asifa Akhtar Thomas Manke
author_facet	Fidel Ramírez Vivek Bhardwaj Laura Arrigoni Kin Chung Lam Björn A. Grüning José Villaveces Bianca Habermann Asifa Akhtar Thomas Manke
author_sort	Fidel Ramírez
title	High-resolution TADs reveal DNA sequences underlying genome organization in flies
title_short	High-resolution TADs reveal DNA sequences underlying genome organization in flies
title_full	High-resolution TADs reveal DNA sequences underlying genome organization in flies
title_fullStr	High-resolution TADs reveal DNA sequences underlying genome organization in flies
title_full_unstemmed	High-resolution TADs reveal DNA sequences underlying genome organization in flies
title_sort	high-resolution tads reveal dna sequences underlying genome organization in flies
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f48cef696c874fc680f5d90d7c13d700
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High-resolution TADs reveal DNA sequences underlying genome organization in flies

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