Novel evolutionary dynamics of small populations in breast cancer adjuvant and neoadjuvant therapy

Abstract Disseminated cancer cells (DCCs) are detected in the circulation and bone marrow of up to 40% of breast cancer (BC) patients with clinically localized disease. The formation of metastases is governed by eco-evolutionary interactions of DCCs with the tissue during the transition from microsc...

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Autores principales:	Yael Artzy-Randrup, Tamir Epstein, Joel S. Brown, Ricardo L. B. Costa, Brian J. Czerniecki, Robert A. Gatenby
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/f49023cafb534e68bae333b8a306dcc9
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spelling	oai:doaj.org-article:f49023cafb534e68bae333b8a306dcc92021-12-02T15:52:55ZNovel evolutionary dynamics of small populations in breast cancer adjuvant and neoadjuvant therapy10.1038/s41523-021-00230-y2374-4677https://doaj.org/article/f49023cafb534e68bae333b8a306dcc92021-03-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00230-yhttps://doaj.org/toc/2374-4677Abstract Disseminated cancer cells (DCCs) are detected in the circulation and bone marrow of up to 40% of breast cancer (BC) patients with clinically localized disease. The formation of metastases is governed by eco-evolutionary interactions of DCCs with the tissue during the transition from microscopic populations to macroscopic disease. Here, we view BC adjuvant and neoadjuvant treatments in the context of small population extinction dynamics observed in the Anthropocene era. Specifically, the unique eco-evolutionary dynamics of small asexually reproducing cancer populations render them highly vulnerable to: (1) environmental and demographic fluctuations, (2) Allee effects, (3) genetic drift and (4) population fragmentation. Furthermore, these typically interact, producing self-reinforcing, destructive dynamics—termed the Extinction Vortex—eradicating the population even when none of the perturbations is individually capable of causing extinction. We propose that developing BC adjuvant and neoadjuvant protocols may exploit these dynamics to prevent recovery and proliferation of small cancer populations during and after treatment—termed “Eco-evolutionary rescue” in natural extinctions. We hypothesize more strategic application of currently available agents based on the extinction vulnerabilities of small populations could improve clinical outcomes.Yael Artzy-RandrupTamir EpsteinJoel S. BrownRicardo L. B. CostaBrian J. CzernieckiRobert A. GatenbyNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yael Artzy-Randrup Tamir Epstein Joel S. Brown Ricardo L. B. Costa Brian J. Czerniecki Robert A. Gatenby Novel evolutionary dynamics of small populations in breast cancer adjuvant and neoadjuvant therapy
description	Abstract Disseminated cancer cells (DCCs) are detected in the circulation and bone marrow of up to 40% of breast cancer (BC) patients with clinically localized disease. The formation of metastases is governed by eco-evolutionary interactions of DCCs with the tissue during the transition from microscopic populations to macroscopic disease. Here, we view BC adjuvant and neoadjuvant treatments in the context of small population extinction dynamics observed in the Anthropocene era. Specifically, the unique eco-evolutionary dynamics of small asexually reproducing cancer populations render them highly vulnerable to: (1) environmental and demographic fluctuations, (2) Allee effects, (3) genetic drift and (4) population fragmentation. Furthermore, these typically interact, producing self-reinforcing, destructive dynamics—termed the Extinction Vortex—eradicating the population even when none of the perturbations is individually capable of causing extinction. We propose that developing BC adjuvant and neoadjuvant protocols may exploit these dynamics to prevent recovery and proliferation of small cancer populations during and after treatment—termed “Eco-evolutionary rescue” in natural extinctions. We hypothesize more strategic application of currently available agents based on the extinction vulnerabilities of small populations could improve clinical outcomes.
format	article
author	Yael Artzy-Randrup Tamir Epstein Joel S. Brown Ricardo L. B. Costa Brian J. Czerniecki Robert A. Gatenby
author_facet	Yael Artzy-Randrup Tamir Epstein Joel S. Brown Ricardo L. B. Costa Brian J. Czerniecki Robert A. Gatenby
author_sort	Yael Artzy-Randrup
title	Novel evolutionary dynamics of small populations in breast cancer adjuvant and neoadjuvant therapy
title_short	Novel evolutionary dynamics of small populations in breast cancer adjuvant and neoadjuvant therapy
title_full	Novel evolutionary dynamics of small populations in breast cancer adjuvant and neoadjuvant therapy
title_fullStr	Novel evolutionary dynamics of small populations in breast cancer adjuvant and neoadjuvant therapy
title_full_unstemmed	Novel evolutionary dynamics of small populations in breast cancer adjuvant and neoadjuvant therapy
title_sort	novel evolutionary dynamics of small populations in breast cancer adjuvant and neoadjuvant therapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f49023cafb534e68bae333b8a306dcc9
work_keys_str_mv	AT yaelartzyrandrup novelevolutionarydynamicsofsmallpopulationsinbreastcanceradjuvantandneoadjuvanttherapy AT tamirepstein novelevolutionarydynamicsofsmallpopulationsinbreastcanceradjuvantandneoadjuvanttherapy AT joelsbrown novelevolutionarydynamicsofsmallpopulationsinbreastcanceradjuvantandneoadjuvanttherapy AT ricardolbcosta novelevolutionarydynamicsofsmallpopulationsinbreastcanceradjuvantandneoadjuvanttherapy AT brianjczerniecki novelevolutionarydynamicsofsmallpopulationsinbreastcanceradjuvantandneoadjuvanttherapy AT robertagatenby novelevolutionarydynamicsofsmallpopulationsinbreastcanceradjuvantandneoadjuvanttherapy
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Novel evolutionary dynamics of small populations in breast cancer adjuvant and neoadjuvant therapy

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