Na+/H+-Exchanger Family as Novel Prognostic Biomarkers in Colorectal Cancer

Background. The acidic characteristics of the tumor microenvironment (TME) are attributed to cancer cells’ needs of metabolism which produce a large amount of H+. In order not to affect its own life activities, it needs to release H+ into the intercellular space through an efficient Na+/H+ exchanger...

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Autores principales:	Xin Zhou, Manman Jiang, Zhihong Liu, Mengmeng Xu, Nannan Chen, Ziyu Wu, Changji Gu, Eugene Chin, Xiaodong Yang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/f4946ba3de5a472d9c7540eae78191cf
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spelling	oai:doaj.org-article:f4946ba3de5a472d9c7540eae78191cf2021-11-15T01:19:56ZNa+/H+-Exchanger Family as Novel Prognostic Biomarkers in Colorectal Cancer1687-846910.1155/2021/3241351https://doaj.org/article/f4946ba3de5a472d9c7540eae78191cf2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/3241351https://doaj.org/toc/1687-8469Background. The acidic characteristics of the tumor microenvironment (TME) are attributed to cancer cells’ needs of metabolism which produce a large amount of H+. In order not to affect its own life activities, it needs to release H+ into the intercellular space through an efficient Na+/H+ exchanger. On account of the intestine whose physiological function is highly dependent on intestinal pH value, NHE family members may play a critical role in the occurrence and development of colorectal cancer (CRC). Methods. TCGA, GEPIA2, ONCOMINE, UALCAN, STRING, TIMER, Cytoscape, TargetScan, ENCORI, LncBase v.2, DNMIVD, HPA, and CellMinerTM databases were used in our study. Results. The mRNA expressions of SLC9A1, SLC9A2, SLC9A3, and SLC9A9 were evidently lower in COAD than in normal samples; however, the mRNA expressions of SLC9A5, SLC9A8, and SLC9B2 were higher. Besides, mRNA expressions of NHE family were extremely associated with clinicopathological features, tumor immune microenvironment and stemness score, DNA methylation, and patient prognosis in COAD. Moreover, we conjectured that NHE family may play a role through MAPK or ErbB signaling pathway according to the results of GO/KEGG enrichment analysis. At last, we found that NHE family members were key factors of various kinds of cancers. Conclusion. Our study indicated that NHE family represented new diagnostic and therapeutic targets for CRC, which could have important significance for the clinical treatment of CRC.Xin ZhouManman JiangZhihong LiuMengmeng XuNannan ChenZiyu WuChangji GuEugene ChinXiaodong YangHindawi LimitedarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of Oncology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Xin Zhou Manman Jiang Zhihong Liu Mengmeng Xu Nannan Chen Ziyu Wu Changji Gu Eugene Chin Xiaodong Yang Na+/H+-Exchanger Family as Novel Prognostic Biomarkers in Colorectal Cancer
description	Background. The acidic characteristics of the tumor microenvironment (TME) are attributed to cancer cells’ needs of metabolism which produce a large amount of H+. In order not to affect its own life activities, it needs to release H+ into the intercellular space through an efficient Na+/H+ exchanger. On account of the intestine whose physiological function is highly dependent on intestinal pH value, NHE family members may play a critical role in the occurrence and development of colorectal cancer (CRC). Methods. TCGA, GEPIA2, ONCOMINE, UALCAN, STRING, TIMER, Cytoscape, TargetScan, ENCORI, LncBase v.2, DNMIVD, HPA, and CellMinerTM databases were used in our study. Results. The mRNA expressions of SLC9A1, SLC9A2, SLC9A3, and SLC9A9 were evidently lower in COAD than in normal samples; however, the mRNA expressions of SLC9A5, SLC9A8, and SLC9B2 were higher. Besides, mRNA expressions of NHE family were extremely associated with clinicopathological features, tumor immune microenvironment and stemness score, DNA methylation, and patient prognosis in COAD. Moreover, we conjectured that NHE family may play a role through MAPK or ErbB signaling pathway according to the results of GO/KEGG enrichment analysis. At last, we found that NHE family members were key factors of various kinds of cancers. Conclusion. Our study indicated that NHE family represented new diagnostic and therapeutic targets for CRC, which could have important significance for the clinical treatment of CRC.
format	article
author	Xin Zhou Manman Jiang Zhihong Liu Mengmeng Xu Nannan Chen Ziyu Wu Changji Gu Eugene Chin Xiaodong Yang
author_facet	Xin Zhou Manman Jiang Zhihong Liu Mengmeng Xu Nannan Chen Ziyu Wu Changji Gu Eugene Chin Xiaodong Yang
author_sort	Xin Zhou
title	Na+/H+-Exchanger Family as Novel Prognostic Biomarkers in Colorectal Cancer
title_short	Na+/H+-Exchanger Family as Novel Prognostic Biomarkers in Colorectal Cancer
title_full	Na+/H+-Exchanger Family as Novel Prognostic Biomarkers in Colorectal Cancer
title_fullStr	Na+/H+-Exchanger Family as Novel Prognostic Biomarkers in Colorectal Cancer
title_full_unstemmed	Na+/H+-Exchanger Family as Novel Prognostic Biomarkers in Colorectal Cancer
title_sort	na+/h+-exchanger family as novel prognostic biomarkers in colorectal cancer
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/f4946ba3de5a472d9c7540eae78191cf
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_version_	1718428960182763520

Na+/H+-Exchanger Family as Novel Prognostic Biomarkers in Colorectal Cancer

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