Associations Between Thyroid Hormones and Glycated Albumin in Euthyroid and Subclinical Hypothyroid Individuals: Results of an Observational Study

Xiaomin Nie,* Yun Shen,* Xiaojing Ma, Yiting Xu, Yufei Wang, Jian Zhou, Yuqian Bao Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shangh...

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Autores principales:	Nie X, Shen Y, Ma X, Xu Y, Wang Y, Zhou J, Bao Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	glycated albumin glycated hemoglobin free triiodothyronine free thyroxine Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/f4985742135045c1bf86fcf51f2ec999
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spelling	oai:doaj.org-article:f4985742135045c1bf86fcf51f2ec9992021-12-02T08:07:36ZAssociations Between Thyroid Hormones and Glycated Albumin in Euthyroid and Subclinical Hypothyroid Individuals: Results of an Observational Study1178-7007https://doaj.org/article/f4985742135045c1bf86fcf51f2ec9992020-03-01T00:00:00Zhttps://www.dovepress.com/associations-between-thyroid-hormones-and-glycated-albumin-in-euthyroi-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Xiaomin Nie,* Yun Shen,* Xiaojing Ma, Yiting Xu, Yufei Wang, Jian Zhou, Yuqian Bao Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaojing Ma; Yuqian BaoDepartment of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, 600 Yishan Road, Shanghai 200233, People’s Republic of ChinaTel +86-21-64369181Fax +86-21-64368031Email maxiaojing@sjtu.edu.cn; yqbao@sjtu.edu.cnPurpose: Although overt thyroid dysfunction has been found to influence the level of glycated albumin (GA), the associations between thyroid hormones and GA in individuals with euthyroidism and subclinical hypothyroidism (SHypo) are still unknown. The present study aimed to investigate whether thyroid hormones were related to GA in euthyroid and SHypo individuals.Methods: We recruited 685 euthyroid and 103 SHypo subjects with normal weight from communities in Shanghai. Electrochemiluminescence immunoassay was used to detect the serum levels of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone. GA was detected by the enzymatic method. Glycated hemoglobin (HbA1c) was detected by high-performance liquid chromatography.Results: Among the 788 subjects (age range 31– 81 years old), 307 were men and 481 were women. In the Spearman correlation analysis and multiple stepwise regression analysis, FT3 was negatively correlated with both GA and GA/HbA1c in euthyroid subjects (all P < 0.05). The values of GA and GA/HbA1c were reduced by approximately 0.30 and 0.05, respectively, for each 0.50 pmol/L increment in FT3. In SHypo subjects, FT4 was negatively associated with both GA and GA/HbA1c (all P < 0.05). The values of GA and GA/HbA1c were reduced by approximately 0.23 and 0.03, respectively, for each 1.00 pmol/L increment in FT4.Conclusion: In euthyroid and SHypo subjects, more attention should be paid to the potential effects of individual differences in thyroid hormones on GA.Keywords: glycated albumin, glycated hemoglobin, free triiodothyronine, free thyroxineNie XShen YMa XXu YWang YZhou JBao YDove Medical Pressarticleglycated albuminglycated hemoglobinfree triiodothyroninefree thyroxineSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 915-923 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	glycated albumin glycated hemoglobin free triiodothyronine free thyroxine Specialties of internal medicine RC581-951
spellingShingle	glycated albumin glycated hemoglobin free triiodothyronine free thyroxine Specialties of internal medicine RC581-951 Nie X Shen Y Ma X Xu Y Wang Y Zhou J Bao Y Associations Between Thyroid Hormones and Glycated Albumin in Euthyroid and Subclinical Hypothyroid Individuals: Results of an Observational Study
description	Xiaomin Nie,* Yun Shen,* Xiaojing Ma, Yiting Xu, Yufei Wang, Jian Zhou, Yuqian Bao Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaojing Ma; Yuqian BaoDepartment of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, 600 Yishan Road, Shanghai 200233, People’s Republic of ChinaTel +86-21-64369181Fax +86-21-64368031Email maxiaojing@sjtu.edu.cn; yqbao@sjtu.edu.cnPurpose: Although overt thyroid dysfunction has been found to influence the level of glycated albumin (GA), the associations between thyroid hormones and GA in individuals with euthyroidism and subclinical hypothyroidism (SHypo) are still unknown. The present study aimed to investigate whether thyroid hormones were related to GA in euthyroid and SHypo individuals.Methods: We recruited 685 euthyroid and 103 SHypo subjects with normal weight from communities in Shanghai. Electrochemiluminescence immunoassay was used to detect the serum levels of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone. GA was detected by the enzymatic method. Glycated hemoglobin (HbA1c) was detected by high-performance liquid chromatography.Results: Among the 788 subjects (age range 31– 81 years old), 307 were men and 481 were women. In the Spearman correlation analysis and multiple stepwise regression analysis, FT3 was negatively correlated with both GA and GA/HbA1c in euthyroid subjects (all P < 0.05). The values of GA and GA/HbA1c were reduced by approximately 0.30 and 0.05, respectively, for each 0.50 pmol/L increment in FT3. In SHypo subjects, FT4 was negatively associated with both GA and GA/HbA1c (all P < 0.05). The values of GA and GA/HbA1c were reduced by approximately 0.23 and 0.03, respectively, for each 1.00 pmol/L increment in FT4.Conclusion: In euthyroid and SHypo subjects, more attention should be paid to the potential effects of individual differences in thyroid hormones on GA.Keywords: glycated albumin, glycated hemoglobin, free triiodothyronine, free thyroxine
format	article
author	Nie X Shen Y Ma X Xu Y Wang Y Zhou J Bao Y
author_facet	Nie X Shen Y Ma X Xu Y Wang Y Zhou J Bao Y
author_sort	Nie X
title	Associations Between Thyroid Hormones and Glycated Albumin in Euthyroid and Subclinical Hypothyroid Individuals: Results of an Observational Study
title_short	Associations Between Thyroid Hormones and Glycated Albumin in Euthyroid and Subclinical Hypothyroid Individuals: Results of an Observational Study
title_full	Associations Between Thyroid Hormones and Glycated Albumin in Euthyroid and Subclinical Hypothyroid Individuals: Results of an Observational Study
title_fullStr	Associations Between Thyroid Hormones and Glycated Albumin in Euthyroid and Subclinical Hypothyroid Individuals: Results of an Observational Study
title_full_unstemmed	Associations Between Thyroid Hormones and Glycated Albumin in Euthyroid and Subclinical Hypothyroid Individuals: Results of an Observational Study
title_sort	associations between thyroid hormones and glycated albumin in euthyroid and subclinical hypothyroid individuals: results of an observational study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/f4985742135045c1bf86fcf51f2ec999
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Associations Between Thyroid Hormones and Glycated Albumin in Euthyroid and Subclinical Hypothyroid Individuals: Results of an Observational Study

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