Adipocyte OGT governs diet-induced hyperphagia and obesity

Endocannabinoid signaling regulates food intake and is a potential therapeutic target for obesity. Here the authors show that adipocyte O-GlcNAc transferase (OGT) is required for high fat diet-induced hyperphagia via transcriptional activation of de novo lipid desaturation and accumulation of an end...

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Autores principales:	Min-Dian Li, Nicholas B. Vera, Yunfan Yang, Bichen Zhang, Weiming Ni, Enida Ziso-Qejvanaj, Sheng Ding, Kaisi Zhang, Ruonan Yin, Simeng Wang, Xu Zhou, Ethan X. Fang, Tian Xu, Derek M. Erion, Xiaoyong Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f49d2d5b81154fdfad2889c2229e7c6b
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spelling	oai:doaj.org-article:f49d2d5b81154fdfad2889c2229e7c6b2021-12-02T15:34:39ZAdipocyte OGT governs diet-induced hyperphagia and obesity10.1038/s41467-018-07461-x2041-1723https://doaj.org/article/f49d2d5b81154fdfad2889c2229e7c6b2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07461-xhttps://doaj.org/toc/2041-1723Endocannabinoid signaling regulates food intake and is a potential therapeutic target for obesity. Here the authors show that adipocyte O-GlcNAc transferase (OGT) is required for high fat diet-induced hyperphagia via transcriptional activation of de novo lipid desaturation and accumulation of an endogenous appetite-inducing cannabinoid.Min-Dian LiNicholas B. VeraYunfan YangBichen ZhangWeiming NiEnida Ziso-QejvanajSheng DingKaisi ZhangRuonan YinSimeng WangXu ZhouEthan X. FangTian XuDerek M. ErionXiaoyong YangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Min-Dian Li Nicholas B. Vera Yunfan Yang Bichen Zhang Weiming Ni Enida Ziso-Qejvanaj Sheng Ding Kaisi Zhang Ruonan Yin Simeng Wang Xu Zhou Ethan X. Fang Tian Xu Derek M. Erion Xiaoyong Yang Adipocyte OGT governs diet-induced hyperphagia and obesity
description	Endocannabinoid signaling regulates food intake and is a potential therapeutic target for obesity. Here the authors show that adipocyte O-GlcNAc transferase (OGT) is required for high fat diet-induced hyperphagia via transcriptional activation of de novo lipid desaturation and accumulation of an endogenous appetite-inducing cannabinoid.
format	article
author	Min-Dian Li Nicholas B. Vera Yunfan Yang Bichen Zhang Weiming Ni Enida Ziso-Qejvanaj Sheng Ding Kaisi Zhang Ruonan Yin Simeng Wang Xu Zhou Ethan X. Fang Tian Xu Derek M. Erion Xiaoyong Yang
author_facet	Min-Dian Li Nicholas B. Vera Yunfan Yang Bichen Zhang Weiming Ni Enida Ziso-Qejvanaj Sheng Ding Kaisi Zhang Ruonan Yin Simeng Wang Xu Zhou Ethan X. Fang Tian Xu Derek M. Erion Xiaoyong Yang
author_sort	Min-Dian Li
title	Adipocyte OGT governs diet-induced hyperphagia and obesity
title_short	Adipocyte OGT governs diet-induced hyperphagia and obesity
title_full	Adipocyte OGT governs diet-induced hyperphagia and obesity
title_fullStr	Adipocyte OGT governs diet-induced hyperphagia and obesity
title_full_unstemmed	Adipocyte OGT governs diet-induced hyperphagia and obesity
title_sort	adipocyte ogt governs diet-induced hyperphagia and obesity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f49d2d5b81154fdfad2889c2229e7c6b
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Adipocyte OGT governs diet-induced hyperphagia and obesity

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