MicroRNA-889-3p restrains the proliferation and epithelial–mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1

Dysregulated microRNAs (miRNAs) are common in human cancers and are involved in the proliferation, promotion, and metastasis of tumor cells. Therefore, the aim of this study was to evaluate the expression and biological function of miR-889-3p in lung cancer (LC). MiR-889-3p and Homeodomain-interacti...

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Autores principales:	Qiang Zhu, Yun Li, Lina Li, Mingxue Guo, Chenxi Zou, Yi Xu, Zhen Yang
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	microrna-889-3p lung cancer cells homeodomain-interacting protein kinase 1 epithelial mesenchymal transition Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/f4a03fca19d94dbfb45497ac06931d4d
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spelling	oai:doaj.org-article:f4a03fca19d94dbfb45497ac06931d4d2021-12-01T14:41:00ZMicroRNA-889-3p restrains the proliferation and epithelial–mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 12165-59792165-598710.1080/21655979.2021.2000283https://doaj.org/article/f4a03fca19d94dbfb45497ac06931d4d2021-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.2000283https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Dysregulated microRNAs (miRNAs) are common in human cancers and are involved in the proliferation, promotion, and metastasis of tumor cells. Therefore, the aim of this study was to evaluate the expression and biological function of miR-889-3p in lung cancer (LC). MiR-889-3p and Homeodomain-interacting protein kinase 1 (HIPK1) expression was detected in human LC tissues and cells. The correlation of miR-889-3p with the clinicopathology of LC patients was observed. After the transfection of miR-889-3p and HIPK1-related plasmids in human LC cell line A549, several studies were employed for detection of cell growth. In addition, the targeting of miR-889-3p with HIPK1 was verified. The results clarified miR-889-3p was down-regulated, while HIPK1 was up-regulated in LC tissues. Elevated miR-889-3p or repressed HIPK1 weakened the viability, epithelial–mesenchymal transition (EMT), invasion, migration of LC cells, whereas strengthened apoptosis. MiR-889-3p targeted HIPK1; MiR-889-3p mediated HIPK1 to affect the proliferation and EMT of LC cells. Therefore, it is concluded that miR-889-3p repressing HIPK1 restrains the proliferation and EMT of LC cells, providing a novel target for LC therapy.Qiang ZhuYun LiLina LiMingxue GuoChenxi ZouYi XuZhen YangTaylor & Francis Grouparticlemicrorna-889-3plung cancer cellshomeodomain-interacting protein kinase 1epithelial mesenchymal transitionBiotechnologyTP248.13-248.65ENBioengineered, Vol 12, Iss 2, Pp 10945-10958 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microrna-889-3p lung cancer cells homeodomain-interacting protein kinase 1 epithelial mesenchymal transition Biotechnology TP248.13-248.65
spellingShingle	microrna-889-3p lung cancer cells homeodomain-interacting protein kinase 1 epithelial mesenchymal transition Biotechnology TP248.13-248.65 Qiang Zhu Yun Li Lina Li Mingxue Guo Chenxi Zou Yi Xu Zhen Yang MicroRNA-889-3p restrains the proliferation and epithelial–mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1
description	Dysregulated microRNAs (miRNAs) are common in human cancers and are involved in the proliferation, promotion, and metastasis of tumor cells. Therefore, the aim of this study was to evaluate the expression and biological function of miR-889-3p in lung cancer (LC). MiR-889-3p and Homeodomain-interacting protein kinase 1 (HIPK1) expression was detected in human LC tissues and cells. The correlation of miR-889-3p with the clinicopathology of LC patients was observed. After the transfection of miR-889-3p and HIPK1-related plasmids in human LC cell line A549, several studies were employed for detection of cell growth. In addition, the targeting of miR-889-3p with HIPK1 was verified. The results clarified miR-889-3p was down-regulated, while HIPK1 was up-regulated in LC tissues. Elevated miR-889-3p or repressed HIPK1 weakened the viability, epithelial–mesenchymal transition (EMT), invasion, migration of LC cells, whereas strengthened apoptosis. MiR-889-3p targeted HIPK1; MiR-889-3p mediated HIPK1 to affect the proliferation and EMT of LC cells. Therefore, it is concluded that miR-889-3p repressing HIPK1 restrains the proliferation and EMT of LC cells, providing a novel target for LC therapy.
format	article
author	Qiang Zhu Yun Li Lina Li Mingxue Guo Chenxi Zou Yi Xu Zhen Yang
author_facet	Qiang Zhu Yun Li Lina Li Mingxue Guo Chenxi Zou Yi Xu Zhen Yang
author_sort	Qiang Zhu
title	MicroRNA-889-3p restrains the proliferation and epithelial–mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1
title_short	MicroRNA-889-3p restrains the proliferation and epithelial–mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1
title_full	MicroRNA-889-3p restrains the proliferation and epithelial–mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1
title_fullStr	MicroRNA-889-3p restrains the proliferation and epithelial–mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1
title_full_unstemmed	MicroRNA-889-3p restrains the proliferation and epithelial–mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1
title_sort	microrna-889-3p restrains the proliferation and epithelial–mesenchymal transformation of lung cancer cells via down-regulation of homeodomain-interacting protein kinase 1
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/f4a03fca19d94dbfb45497ac06931d4d
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MicroRNA-889-3p restrains the proliferation and epithelial–mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1

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