Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Obesity

The incidence of obesity has dramatically increased over the last decades. Recently, there has been a growing interest in the possible association between the pandemics of obesity and some endocrine-disrupting chemicals (EDCs), termed “obesogens”. These are a heterogeneous group of exogenous compoun...

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Autores principales:	Immacolata Cristina Nettore, Fabiana Franchini, Giuseppe Palatucci, Paolo Emidio Macchia, Paola Ungaro
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	epigenetic endocrine-disrupting chemicals obesity obesogens DNA methylation histone modifications Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f4a0ba1fcfdd40e2975f656ed0f25744
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spelling	oai:doaj.org-article:f4a0ba1fcfdd40e2975f656ed0f257442021-11-25T16:51:11ZEpigenetic Mechanisms of Endocrine-Disrupting Chemicals in Obesity10.3390/biomedicines91117162227-9059https://doaj.org/article/f4a0ba1fcfdd40e2975f656ed0f257442021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1716https://doaj.org/toc/2227-9059The incidence of obesity has dramatically increased over the last decades. Recently, there has been a growing interest in the possible association between the pandemics of obesity and some endocrine-disrupting chemicals (EDCs), termed “obesogens”. These are a heterogeneous group of exogenous compounds that can interfere in the endocrine regulation of energy metabolism and adipose tissue structure. Oral intake, inhalation, and dermal absorption represent the major sources of human exposure to these EDCs. Recently, epigenetic changes such as the methylation of cytosine residues on DNA, post-translational modification of histones, and microRNA expression have been considered to act as an intermediary between deleterious effects of EDCs and obesity development in susceptible individuals. Specifically, EDCs exposure during early-life development can detrimentally affect individuals via inducing epigenetic modifications that can permanently change the epigenome in the germline, enabling changes to be transmitted to the next generations and predisposing them to a multitude of diseases. The purpose of this review is to analyze the epigenetic alterations putatively induced by chemical exposures and their ability to interfere with the control of energy metabolism and adipose tissue regulation, resulting in imbalances in the control of body weight, which can lead to obesity.Immacolata Cristina NettoreFabiana FranchiniGiuseppe PalatucciPaolo Emidio MacchiaPaola UngaroMDPI AGarticleepigeneticendocrine-disrupting chemicalsobesityobesogensDNA methylationhistone modificationsBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1716, p 1716 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	epigenetic endocrine-disrupting chemicals obesity obesogens DNA methylation histone modifications Biology (General) QH301-705.5
spellingShingle	epigenetic endocrine-disrupting chemicals obesity obesogens DNA methylation histone modifications Biology (General) QH301-705.5 Immacolata Cristina Nettore Fabiana Franchini Giuseppe Palatucci Paolo Emidio Macchia Paola Ungaro Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Obesity
description	The incidence of obesity has dramatically increased over the last decades. Recently, there has been a growing interest in the possible association between the pandemics of obesity and some endocrine-disrupting chemicals (EDCs), termed “obesogens”. These are a heterogeneous group of exogenous compounds that can interfere in the endocrine regulation of energy metabolism and adipose tissue structure. Oral intake, inhalation, and dermal absorption represent the major sources of human exposure to these EDCs. Recently, epigenetic changes such as the methylation of cytosine residues on DNA, post-translational modification of histones, and microRNA expression have been considered to act as an intermediary between deleterious effects of EDCs and obesity development in susceptible individuals. Specifically, EDCs exposure during early-life development can detrimentally affect individuals via inducing epigenetic modifications that can permanently change the epigenome in the germline, enabling changes to be transmitted to the next generations and predisposing them to a multitude of diseases. The purpose of this review is to analyze the epigenetic alterations putatively induced by chemical exposures and their ability to interfere with the control of energy metabolism and adipose tissue regulation, resulting in imbalances in the control of body weight, which can lead to obesity.
format	article
author	Immacolata Cristina Nettore Fabiana Franchini Giuseppe Palatucci Paolo Emidio Macchia Paola Ungaro
author_facet	Immacolata Cristina Nettore Fabiana Franchini Giuseppe Palatucci Paolo Emidio Macchia Paola Ungaro
author_sort	Immacolata Cristina Nettore
title	Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Obesity
title_short	Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Obesity
title_full	Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Obesity
title_fullStr	Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Obesity
title_full_unstemmed	Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Obesity
title_sort	epigenetic mechanisms of endocrine-disrupting chemicals in obesity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f4a0ba1fcfdd40e2975f656ed0f25744
work_keys_str_mv	AT immacolatacristinanettore epigeneticmechanismsofendocrinedisruptingchemicalsinobesity AT fabianafranchini epigeneticmechanismsofendocrinedisruptingchemicalsinobesity AT giuseppepalatucci epigeneticmechanismsofendocrinedisruptingchemicalsinobesity AT paoloemidiomacchia epigeneticmechanismsofendocrinedisruptingchemicalsinobesity AT paolaungaro epigeneticmechanismsofendocrinedisruptingchemicalsinobesity
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Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Obesity

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