THE CLINICAL PICTURE AND LABORATORY WORK-UP OF GLANZMANN THROMBASTHENIA

Case report: We present the clinical picture and laboratory work-up of Glanzmann thrombasthenia, based on a group of 7 patients. Bleeding history was significant in all patients and included both mucosal and postsurgery bleeds. Laboratory analysis revealed decreased or absent platelet aggregation (&...

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Autores principales:	Joanna Zdziarska, Teresa Iwaniec, Tomasz Sacha, Ewa Wypasek
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/f4a505a9ea3941f4aa873c121c4ff1ff
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spelling	oai:doaj.org-article:f4a505a9ea3941f4aa873c121c4ff1ff2021-11-10T04:38:17ZTHE CLINICAL PICTURE AND LABORATORY WORK-UP OF GLANZMANN THROMBASTHENIA2531-137910.1016/j.htct.2021.10.1071https://doaj.org/article/f4a505a9ea3941f4aa873c121c4ff1ff2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2531137921012189https://doaj.org/toc/2531-1379Case report: We present the clinical picture and laboratory work-up of Glanzmann thrombasthenia, based on a group of 7 patients. Bleeding history was significant in all patients and included both mucosal and postsurgery bleeds. Laboratory analysis revealed decreased or absent platelet aggregation (< 10%) with all physiologic agonists (ADP, collagen, epinephrin, arachidonic acid) together with normal agglutination response to ristocetin. In three patients diagnosis was confirmed by flow cytometry.Joanna ZdziarskaTeresa IwaniecTomasz SachaEwa WypasekElsevierarticleDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss , Pp S56- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Joanna Zdziarska Teresa Iwaniec Tomasz Sacha Ewa Wypasek THE CLINICAL PICTURE AND LABORATORY WORK-UP OF GLANZMANN THROMBASTHENIA
description	Case report: We present the clinical picture and laboratory work-up of Glanzmann thrombasthenia, based on a group of 7 patients. Bleeding history was significant in all patients and included both mucosal and postsurgery bleeds. Laboratory analysis revealed decreased or absent platelet aggregation (< 10%) with all physiologic agonists (ADP, collagen, epinephrin, arachidonic acid) together with normal agglutination response to ristocetin. In three patients diagnosis was confirmed by flow cytometry.
format	article
author	Joanna Zdziarska Teresa Iwaniec Tomasz Sacha Ewa Wypasek
author_facet	Joanna Zdziarska Teresa Iwaniec Tomasz Sacha Ewa Wypasek
author_sort	Joanna Zdziarska
title	THE CLINICAL PICTURE AND LABORATORY WORK-UP OF GLANZMANN THROMBASTHENIA
title_short	THE CLINICAL PICTURE AND LABORATORY WORK-UP OF GLANZMANN THROMBASTHENIA
title_full	THE CLINICAL PICTURE AND LABORATORY WORK-UP OF GLANZMANN THROMBASTHENIA
title_fullStr	THE CLINICAL PICTURE AND LABORATORY WORK-UP OF GLANZMANN THROMBASTHENIA
title_full_unstemmed	THE CLINICAL PICTURE AND LABORATORY WORK-UP OF GLANZMANN THROMBASTHENIA
title_sort	clinical picture and laboratory work-up of glanzmann thrombasthenia
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f4a505a9ea3941f4aa873c121c4ff1ff
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THE CLINICAL PICTURE AND LABORATORY WORK-UP OF GLANZMANN THROMBASTHENIA

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