Reduction of pTau and APP levels in mammalian brain after low-dose radiation

Abstract Brain radiation can occur from treatment of brain tumors or accidental exposures. Brain radiation has been rarely considered, though, as a possible tool to alter protein levels involved in neurodegenerative disorders. We analyzed possible molecular and neuropathology changes of phosphorylat...

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Autores principales:	Diego Iacono, Erin K. Murphy, Soundarya S. Avantsa, Daniel P. Perl, Regina M. Day
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f4a60ba268b34dcf8e930a5f89c10045
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spelling	oai:doaj.org-article:f4a60ba268b34dcf8e930a5f89c100452021-12-02T10:48:22ZReduction of pTau and APP levels in mammalian brain after low-dose radiation10.1038/s41598-021-81602-z2045-2322https://doaj.org/article/f4a60ba268b34dcf8e930a5f89c100452021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81602-zhttps://doaj.org/toc/2045-2322Abstract Brain radiation can occur from treatment of brain tumors or accidental exposures. Brain radiation has been rarely considered, though, as a possible tool to alter protein levels involved in neurodegenerative disorders. We analyzed possible molecular and neuropathology changes of phosphorylated-Tau (pTau), all-Tau forms, β-tubulin, amyloid precursor protein (APP), glial fibrillary acidic protein (GFAP), ionized calcium binding adaptor molecule 1 (IBA-1), myelin basic protein (MBP), and GAP43 in Frontal Cortex (FC), Hippocampus (H) and Cerebellum (CRB) of swine brains following total-body low-dose radiation (1.79 Gy). Our data show that radiated-animals had lower levels of pTau in FC and H, APP in H and CRB, GAP43 in CRB, and higher level of GFAP in H versus sham-animals. These molecular changes were not accompanied by obvious neurohistological changes, except for astrogliosis in the H. These findings are novel, and might open new perspectives on brain radiation as a potential tool to interfere with the accumulation of specific proteins linked to the pathogenesis of various neurodegenerative disorders.Diego IaconoErin K. MurphySoundarya S. AvantsaDaniel P. PerlRegina M. DayNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Diego Iacono Erin K. Murphy Soundarya S. Avantsa Daniel P. Perl Regina M. Day Reduction of pTau and APP levels in mammalian brain after low-dose radiation
description	Abstract Brain radiation can occur from treatment of brain tumors or accidental exposures. Brain radiation has been rarely considered, though, as a possible tool to alter protein levels involved in neurodegenerative disorders. We analyzed possible molecular and neuropathology changes of phosphorylated-Tau (pTau), all-Tau forms, β-tubulin, amyloid precursor protein (APP), glial fibrillary acidic protein (GFAP), ionized calcium binding adaptor molecule 1 (IBA-1), myelin basic protein (MBP), and GAP43 in Frontal Cortex (FC), Hippocampus (H) and Cerebellum (CRB) of swine brains following total-body low-dose radiation (1.79 Gy). Our data show that radiated-animals had lower levels of pTau in FC and H, APP in H and CRB, GAP43 in CRB, and higher level of GFAP in H versus sham-animals. These molecular changes were not accompanied by obvious neurohistological changes, except for astrogliosis in the H. These findings are novel, and might open new perspectives on brain radiation as a potential tool to interfere with the accumulation of specific proteins linked to the pathogenesis of various neurodegenerative disorders.
format	article
author	Diego Iacono Erin K. Murphy Soundarya S. Avantsa Daniel P. Perl Regina M. Day
author_facet	Diego Iacono Erin K. Murphy Soundarya S. Avantsa Daniel P. Perl Regina M. Day
author_sort	Diego Iacono
title	Reduction of pTau and APP levels in mammalian brain after low-dose radiation
title_short	Reduction of pTau and APP levels in mammalian brain after low-dose radiation
title_full	Reduction of pTau and APP levels in mammalian brain after low-dose radiation
title_fullStr	Reduction of pTau and APP levels in mammalian brain after low-dose radiation
title_full_unstemmed	Reduction of pTau and APP levels in mammalian brain after low-dose radiation
title_sort	reduction of ptau and app levels in mammalian brain after low-dose radiation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f4a60ba268b34dcf8e930a5f89c10045
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Reduction of pTau and APP levels in mammalian brain after low-dose radiation

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