Hepatitis B virus and Homo sapiens proteomewide analysis: A profusion of viral peptide overlaps in neuron-specific human proteins

Rosalia Ricco1, Darja Kanduc21Department of Pathological Anatomy, 2Department of Biochemistry and Molecular Biology, University of Bari, Bari, ItalyAbstract: The primary amino acid sequence of the hepatitis B virus (HBV) proteome was searched for identity spots in the human proteome by using the Pro...

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Autores principales:	Rosalia Ricco, Darja Kanduc
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f4ae7a1069cf40d89f6117e1dc519ed0
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spelling	oai:doaj.org-article:f4ae7a1069cf40d89f6117e1dc519ed02021-12-02T02:48:53ZHepatitis B virus and Homo sapiens proteomewide analysis: A profusion of viral peptide overlaps in neuron-specific human proteins1177-54751177-5491https://doaj.org/article/f4ae7a1069cf40d89f6117e1dc519ed02010-04-01T00:00:00Zhttp://www.dovepress.com/hepatitis-b-virus-and-homo-sapiens-proteomewide-analysis-a-profusion-o-a4191https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Rosalia Ricco1, Darja Kanduc21Department of Pathological Anatomy, 2Department of Biochemistry and Molecular Biology, University of Bari, Bari, ItalyAbstract: The primary amino acid sequence of the hepatitis B virus (HBV) proteome was searched for identity spots in the human proteome by using the Protein Information Resource database. We find that the HBV polyprotein shares sixty-five heptapeptides, one octapeptide, and one nonapeptide with the human proteins. The viral matches are disseminated among fundamental human proteins such as adhesion molecules, leukocyte differentiation antigens, enzymes, proteins associated with spermatogenesis, and transcription factors. As a datum of special interest, a number of peptide motifs are shared between the virus- and brain-specific antigens involved in neuronal protection. This study may help to evaluate the potential cross reactions and side effects of HBV antigen-based vaccines.Keywords: HBV proteome, human proteome, similarity analysis, viral versus human proteome overlapping, vaccine-related cross-reactions Rosalia RiccoDarja KanducDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2010, Iss default, Pp 75-81 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Rosalia Ricco Darja Kanduc Hepatitis B virus and Homo sapiens proteomewide analysis: A profusion of viral peptide overlaps in neuron-specific human proteins
description	Rosalia Ricco1, Darja Kanduc21Department of Pathological Anatomy, 2Department of Biochemistry and Molecular Biology, University of Bari, Bari, ItalyAbstract: The primary amino acid sequence of the hepatitis B virus (HBV) proteome was searched for identity spots in the human proteome by using the Protein Information Resource database. We find that the HBV polyprotein shares sixty-five heptapeptides, one octapeptide, and one nonapeptide with the human proteins. The viral matches are disseminated among fundamental human proteins such as adhesion molecules, leukocyte differentiation antigens, enzymes, proteins associated with spermatogenesis, and transcription factors. As a datum of special interest, a number of peptide motifs are shared between the virus- and brain-specific antigens involved in neuronal protection. This study may help to evaluate the potential cross reactions and side effects of HBV antigen-based vaccines.Keywords: HBV proteome, human proteome, similarity analysis, viral versus human proteome overlapping, vaccine-related cross-reactions
format	article
author	Rosalia Ricco Darja Kanduc
author_facet	Rosalia Ricco Darja Kanduc
author_sort	Rosalia Ricco
title	Hepatitis B virus and Homo sapiens proteomewide analysis: A profusion of viral peptide overlaps in neuron-specific human proteins
title_short	Hepatitis B virus and Homo sapiens proteomewide analysis: A profusion of viral peptide overlaps in neuron-specific human proteins
title_full	Hepatitis B virus and Homo sapiens proteomewide analysis: A profusion of viral peptide overlaps in neuron-specific human proteins
title_fullStr	Hepatitis B virus and Homo sapiens proteomewide analysis: A profusion of viral peptide overlaps in neuron-specific human proteins
title_full_unstemmed	Hepatitis B virus and Homo sapiens proteomewide analysis: A profusion of viral peptide overlaps in neuron-specific human proteins
title_sort	hepatitis b virus and homo sapiens proteomewide analysis: a profusion of viral peptide overlaps in neuron-specific human proteins
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/f4ae7a1069cf40d89f6117e1dc519ed0
work_keys_str_mv	AT rosaliaricco hepatitisbvirusandhomosapiensproteomewideanalysisaprofusionofviralpeptideoverlapsinneuronspecifichumanproteins AT darjakanduc hepatitisbvirusandhomosapiensproteomewideanalysisaprofusionofviralpeptideoverlapsinneuronspecifichumanproteins
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Hepatitis B virus and Homo sapiens proteomewide analysis: A profusion of viral peptide overlaps in neuron-specific human proteins

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