DNA binding strength increases the processivity and activity of a Y-Family DNA polymerase

Abstract DNA polymerase (pol) processivity, i.e., the bases a polymerase extends before falling off the DNA, and activity are important for copying difficult DNA sequences, including simple repeats. Y-family pols would be appealing for copying difficult DNA and incorporating non-natural dNTPs, due t...

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Auteurs principaux: Jing Wu, Alexandra de Paz, Bradley M. Zamft, Adam H. Marblestone, Edward S. Boyden, Konrad P. Kording, Keith E. J. Tyo
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Accès en ligne:https://doaj.org/article/f4b1ec7d932b45bca5803a0278a5f0b6
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