Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis

Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis

Treg cells can maintain intestinal homeostasis and limit intestinal bowel disease. Here the authors use a mouse model of spontaneous colitis to show that calcineurin-NFAT-induced IL-2 production by dendritic cells regulates the balance between Treg and effector T cells in the gut lamina propria.

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Autores principales: Andrea Mencarelli, Hanif Javanmard Khameneh, Jan Fric, Maurizio Vacca, Sary El Daker, Baptiste Janela, Jing Ping Tang, Sabrina Nabti, Akhila Balachander, Tong Seng Lim, Florent Ginhoux, Paola Ricciardi-Castagnoli, Alessandra Mortellaro
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
Q
Acceso en línea:https://doaj.org/article/f4b2627b710a44c8a5cd966297f696e0
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spelling oai:doaj.org-article:f4b2627b710a44c8a5cd966297f696e02021-12-02T16:50:11ZCalcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis10.1038/s41467-018-03495-32041-1723https://doaj.org/article/f4b2627b710a44c8a5cd966297f696e02018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03495-3https://doaj.org/toc/2041-1723Treg cells can maintain intestinal homeostasis and limit intestinal bowel disease. Here the authors use a mouse model of spontaneous colitis to show that calcineurin-NFAT-induced IL-2 production by dendritic cells regulates the balance between Treg and effector T cells in the gut lamina propria.Andrea MencarelliHanif Javanmard KhamenehJan FricMaurizio VaccaSary El DakerBaptiste JanelaJing Ping TangSabrina NabtiAkhila BalachanderTong Seng LimFlorent GinhouxPaola Ricciardi-CastagnoliAlessandra MortellaroNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Andrea Mencarelli
Hanif Javanmard Khameneh
Jan Fric
Maurizio Vacca
Sary El Daker
Baptiste Janela
Jing Ping Tang
Sabrina Nabti
Akhila Balachander
Tong Seng Lim
Florent Ginhoux
Paola Ricciardi-Castagnoli
Alessandra Mortellaro
Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis
description Treg cells can maintain intestinal homeostasis and limit intestinal bowel disease. Here the authors use a mouse model of spontaneous colitis to show that calcineurin-NFAT-induced IL-2 production by dendritic cells regulates the balance between Treg and effector T cells in the gut lamina propria.
format article
author Andrea Mencarelli
Hanif Javanmard Khameneh
Jan Fric
Maurizio Vacca
Sary El Daker
Baptiste Janela
Jing Ping Tang
Sabrina Nabti
Akhila Balachander
Tong Seng Lim
Florent Ginhoux
Paola Ricciardi-Castagnoli
Alessandra Mortellaro
author_facet Andrea Mencarelli
Hanif Javanmard Khameneh
Jan Fric
Maurizio Vacca
Sary El Daker
Baptiste Janela
Jing Ping Tang
Sabrina Nabti
Akhila Balachander
Tong Seng Lim
Florent Ginhoux
Paola Ricciardi-Castagnoli
Alessandra Mortellaro
author_sort Andrea Mencarelli
title Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis
title_short Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis
title_full Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis
title_fullStr Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis
title_full_unstemmed Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis
title_sort calcineurin-mediated il-2 production by cd11chighmhcii+ myeloid cells is crucial for intestinal immune homeostasis
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/f4b2627b710a44c8a5cd966297f696e0
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