THERMODYNAMICS OF THE MIXING PROCESS OF SEVERAL SODIUM SULFONAMIDES IN ETHANOL + WATER COSOLVENT MIXTURES

Sodium sulfonamides have been extensively used for the treatment of certain infections caused by several types of microorganisms. Although sulfonamides are still widely used in therapeutics, the physicochemical information about their aqueous solutions has not been completed. In this context, the th...

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Autores principales:	Daniel R. DELGADO, Edgar F. VARGAS, Fleming MARTÍNEZ
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2011
Materias:	Sodium sulfonamides mixing process cosolvency ethanol solution thermodynamics. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/f4b32150a0e34b73a2a6210e7b0a0843
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spelling	oai:doaj.org-article:f4b32150a0e34b73a2a6210e7b0a08432021-11-19T04:13:43ZTHERMODYNAMICS OF THE MIXING PROCESS OF SEVERAL SODIUM SULFONAMIDES IN ETHANOL + WATER COSOLVENT MIXTURES0121-40042145-2660https://doaj.org/article/f4b32150a0e34b73a2a6210e7b0a08432011-09-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/10072https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660Sodium sulfonamides have been extensively used for the treatment of certain infections caused by several types of microorganisms. Although sulfonamides are still widely used in therapeutics, the physicochemical information about their aqueous solutions has not been completed. In this context, the thermodynamic functions of mixing three structurally related sodium sulfonamides were evaluated: Gibbs energy, enthalpy, and entropy. The quantities of mixing were calculated based on the fusion calorimetric values obtained from differential scanning calorimetry measurements and equilibrium solubility values reported in the literature for all the drugs with ethanol + water mixtures. By means of an enthalpy-entropy compensation analysis, non-linear ΔH0mix vs. ΔG0mix plots with negative slopes from neat ethanol to a 0.60 ethanol mass fraction, and positive slopes from the latter composition to neat water were obtained. From these results, it was concluded that the dissolution process of these drugs in ethanol-rich mixtures was entropy-driven; whereas, in water-rich mixtures the process was enthalpy-driven. Nevertheless, the molecular and ionic events involved in the dissolution of these drugs in this cosolvent system remain unclear.Daniel R. DELGADOEdgar F. VARGASFleming MARTÍNEZUniversidad de AntioquiaarticleSodium sulfonamidesmixing processcosolvencyethanolsolution thermodynamics.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 18, Iss 2 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sodium sulfonamides mixing process cosolvency ethanol solution thermodynamics. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Sodium sulfonamides mixing process cosolvency ethanol solution thermodynamics. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Daniel R. DELGADO Edgar F. VARGAS Fleming MARTÍNEZ THERMODYNAMICS OF THE MIXING PROCESS OF SEVERAL SODIUM SULFONAMIDES IN ETHANOL + WATER COSOLVENT MIXTURES
description	Sodium sulfonamides have been extensively used for the treatment of certain infections caused by several types of microorganisms. Although sulfonamides are still widely used in therapeutics, the physicochemical information about their aqueous solutions has not been completed. In this context, the thermodynamic functions of mixing three structurally related sodium sulfonamides were evaluated: Gibbs energy, enthalpy, and entropy. The quantities of mixing were calculated based on the fusion calorimetric values obtained from differential scanning calorimetry measurements and equilibrium solubility values reported in the literature for all the drugs with ethanol + water mixtures. By means of an enthalpy-entropy compensation analysis, non-linear ΔH0mix vs. ΔG0mix plots with negative slopes from neat ethanol to a 0.60 ethanol mass fraction, and positive slopes from the latter composition to neat water were obtained. From these results, it was concluded that the dissolution process of these drugs in ethanol-rich mixtures was entropy-driven; whereas, in water-rich mixtures the process was enthalpy-driven. Nevertheless, the molecular and ionic events involved in the dissolution of these drugs in this cosolvent system remain unclear.
format	article
author	Daniel R. DELGADO Edgar F. VARGAS Fleming MARTÍNEZ
author_facet	Daniel R. DELGADO Edgar F. VARGAS Fleming MARTÍNEZ
author_sort	Daniel R. DELGADO
title	THERMODYNAMICS OF THE MIXING PROCESS OF SEVERAL SODIUM SULFONAMIDES IN ETHANOL + WATER COSOLVENT MIXTURES
title_short	THERMODYNAMICS OF THE MIXING PROCESS OF SEVERAL SODIUM SULFONAMIDES IN ETHANOL + WATER COSOLVENT MIXTURES
title_full	THERMODYNAMICS OF THE MIXING PROCESS OF SEVERAL SODIUM SULFONAMIDES IN ETHANOL + WATER COSOLVENT MIXTURES
title_fullStr	THERMODYNAMICS OF THE MIXING PROCESS OF SEVERAL SODIUM SULFONAMIDES IN ETHANOL + WATER COSOLVENT MIXTURES
title_full_unstemmed	THERMODYNAMICS OF THE MIXING PROCESS OF SEVERAL SODIUM SULFONAMIDES IN ETHANOL + WATER COSOLVENT MIXTURES
title_sort	thermodynamics of the mixing process of several sodium sulfonamides in ethanol + water cosolvent mixtures
publisher	Universidad de Antioquia
publishDate	2011
url	https://doaj.org/article/f4b32150a0e34b73a2a6210e7b0a0843
work_keys_str_mv	AT danielrdelgado thermodynamicsofthemixingprocessofseveralsodiumsulfonamidesinethanolwatercosolventmixtures AT edgarfvargas thermodynamicsofthemixingprocessofseveralsodiumsulfonamidesinethanolwatercosolventmixtures AT flemingmartinez thermodynamicsofthemixingprocessofseveralsodiumsulfonamidesinethanolwatercosolventmixtures
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THERMODYNAMICS OF THE MIXING PROCESS OF SEVERAL SODIUM SULFONAMIDES IN ETHANOL + WATER COSOLVENT MIXTURES

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