MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme

Mitochondria maintain a balance between thermogenesis and ATP synthesis, but how this is coordinated is largely unknown. Here, the authors show that MFSD7C coordinates ATP synthesis and thermogenesis in response to heme by directly binding to electron transport chain complexes and SERCA2b.

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Autores principales:	Yingzhong Li, Nikola A. Ivica, Ting Dong, Dimitrios P. Papageorgiou, Yanpu He, Douglas R. Brown, Marianna Kleyman, Guangan Hu, Walter W. Chen, Lucas B. Sullivan, Amanda Del Rosario, Paula T. Hammond, Matthew G. Vander Heiden, Jianzhu Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f4b39f9789c94baca207b22daeaf19cc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:f4b39f9789c94baca207b22daeaf19cc2021-12-02T17:26:57ZMFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme10.1038/s41467-020-18607-12041-1723https://doaj.org/article/f4b39f9789c94baca207b22daeaf19cc2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18607-1https://doaj.org/toc/2041-1723Mitochondria maintain a balance between thermogenesis and ATP synthesis, but how this is coordinated is largely unknown. Here, the authors show that MFSD7C coordinates ATP synthesis and thermogenesis in response to heme by directly binding to electron transport chain complexes and SERCA2b.Yingzhong LiNikola A. IvicaTing DongDimitrios P. PapageorgiouYanpu HeDouglas R. BrownMarianna KleymanGuangan HuWalter W. ChenLucas B. SullivanAmanda Del RosarioPaula T. HammondMatthew G. Vander HeidenJianzhu ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yingzhong Li Nikola A. Ivica Ting Dong Dimitrios P. Papageorgiou Yanpu He Douglas R. Brown Marianna Kleyman Guangan Hu Walter W. Chen Lucas B. Sullivan Amanda Del Rosario Paula T. Hammond Matthew G. Vander Heiden Jianzhu Chen MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme
description	Mitochondria maintain a balance between thermogenesis and ATP synthesis, but how this is coordinated is largely unknown. Here, the authors show that MFSD7C coordinates ATP synthesis and thermogenesis in response to heme by directly binding to electron transport chain complexes and SERCA2b.
format	article
author	Yingzhong Li Nikola A. Ivica Ting Dong Dimitrios P. Papageorgiou Yanpu He Douglas R. Brown Marianna Kleyman Guangan Hu Walter W. Chen Lucas B. Sullivan Amanda Del Rosario Paula T. Hammond Matthew G. Vander Heiden Jianzhu Chen
author_facet	Yingzhong Li Nikola A. Ivica Ting Dong Dimitrios P. Papageorgiou Yanpu He Douglas R. Brown Marianna Kleyman Guangan Hu Walter W. Chen Lucas B. Sullivan Amanda Del Rosario Paula T. Hammond Matthew G. Vander Heiden Jianzhu Chen
author_sort	Yingzhong Li
title	MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme
title_short	MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme
title_full	MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme
title_fullStr	MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme
title_full_unstemmed	MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme
title_sort	mfsd7c switches mitochondrial atp synthesis to thermogenesis in response to heme
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f4b39f9789c94baca207b22daeaf19cc
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MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme

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