Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis

While being known as a transcription factor, Kruppel-like factor 4 (Klf4) may have other molecular functions. This study shows that Klf4 in neural progenitor cells regulate neurogenesis and self-renewal by interacting with RNA-binding protein Staufen1 and RNA helicase Ddx5/17 to control mRNA decay.

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Autores principales:	Byoung-San Moon, Jinlun Bai, Mingyang Cai, Chunming Liu, Jiandang Shi, Wange Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f4bb66914ce74744b74376ccdc9f2c05
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spelling	oai:doaj.org-article:f4bb66914ce74744b74376ccdc9f2c052021-12-02T14:40:06ZKruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis10.1038/s41467-017-02720-92041-1723https://doaj.org/article/f4bb66914ce74744b74376ccdc9f2c052018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02720-9https://doaj.org/toc/2041-1723While being known as a transcription factor, Kruppel-like factor 4 (Klf4) may have other molecular functions. This study shows that Klf4 in neural progenitor cells regulate neurogenesis and self-renewal by interacting with RNA-binding protein Staufen1 and RNA helicase Ddx5/17 to control mRNA decay.Byoung-San MoonJinlun BaiMingyang CaiChunming LiuJiandang ShiWange LuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Byoung-San Moon Jinlun Bai Mingyang Cai Chunming Liu Jiandang Shi Wange Lu Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis
description	While being known as a transcription factor, Kruppel-like factor 4 (Klf4) may have other molecular functions. This study shows that Klf4 in neural progenitor cells regulate neurogenesis and self-renewal by interacting with RNA-binding protein Staufen1 and RNA helicase Ddx5/17 to control mRNA decay.
format	article
author	Byoung-San Moon Jinlun Bai Mingyang Cai Chunming Liu Jiandang Shi Wange Lu
author_facet	Byoung-San Moon Jinlun Bai Mingyang Cai Chunming Liu Jiandang Shi Wange Lu
author_sort	Byoung-San Moon
title	Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis
title_short	Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis
title_full	Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis
title_fullStr	Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis
title_full_unstemmed	Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis
title_sort	kruppel-like factor 4-dependent staufen1-mediated mrna decay regulates cortical neurogenesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f4bb66914ce74744b74376ccdc9f2c05
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Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis

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