Prevalence of antidepressant use during pregnancy in Denmark, a nation-wide cohort study.

<h4>Aim</h4>The aim of this study was to assess the prevalence and patterns of exposure to antidepressants before, during and after pregnancy in a cohort including all pregnant women in Denmark between 1997 and 2010.<h4>Methods</h4>We performed a retrospective cohort study in...

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Autores principales:	Espen Jimenez-Solem, Jon Trærup Andersen, Morten Petersen, Kasper Broedbaek, Nadia Lyhne Andersen, Christian Torp-Pedersen, Henrik Enghusen Poulsen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f4bfcdc76a214710ba69a7678e2a8959
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spelling	oai:doaj.org-article:f4bfcdc76a214710ba69a7678e2a89592021-11-18T07:47:47ZPrevalence of antidepressant use during pregnancy in Denmark, a nation-wide cohort study.1932-620310.1371/journal.pone.0063034https://doaj.org/article/f4bfcdc76a214710ba69a7678e2a89592013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23638179/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Aim</h4>The aim of this study was to assess the prevalence and patterns of exposure to antidepressants before, during and after pregnancy in a cohort including all pregnant women in Denmark between 1997 and 2010.<h4>Methods</h4>We performed a retrospective cohort study including 912 322 pregnancies. Information was retrieved from the Danish Birth Registry and The Register of Medicinal Product Statistics to identify women redeeming an antidepressant prescription during pregnancy. Exposure periods were based on standard treatment doses and dispensed pack sizes.<h4>Results</h4>We identified 19 740 pregnancies exposed to an antidepressant at some point during pregnancy. The rate of exposure increased from 0.2% in 1997 to 3.2% in 2010. We found that the rate of exposure was halved during the first 3 months of pregnancy. In contrast, we describe a clear increase in exposure after pregnancy among pre-delivery treatment-naïve women.<h4>Conclusions</h4>In spite of uncertainty concerning antidepressants' safety during pregnancy we find a 16-fold increase in exposure rates between 1997 and 2010. The rates describe a sharp decrease in exposure during pregnancy that is probably caused by physicians' hesitation to prescribe antidepressants and women's fear of unwanted effects on the unborn child. More studies are needed to clarify the consequences of antidepressant discontinuation during pregnancy.Espen Jimenez-SolemJon Trærup AndersenMorten PetersenKasper BroedbaekNadia Lyhne AndersenChristian Torp-PedersenHenrik Enghusen PoulsenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e63034 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Espen Jimenez-Solem Jon Trærup Andersen Morten Petersen Kasper Broedbaek Nadia Lyhne Andersen Christian Torp-Pedersen Henrik Enghusen Poulsen Prevalence of antidepressant use during pregnancy in Denmark, a nation-wide cohort study.
description	<h4>Aim</h4>The aim of this study was to assess the prevalence and patterns of exposure to antidepressants before, during and after pregnancy in a cohort including all pregnant women in Denmark between 1997 and 2010.<h4>Methods</h4>We performed a retrospective cohort study including 912 322 pregnancies. Information was retrieved from the Danish Birth Registry and The Register of Medicinal Product Statistics to identify women redeeming an antidepressant prescription during pregnancy. Exposure periods were based on standard treatment doses and dispensed pack sizes.<h4>Results</h4>We identified 19 740 pregnancies exposed to an antidepressant at some point during pregnancy. The rate of exposure increased from 0.2% in 1997 to 3.2% in 2010. We found that the rate of exposure was halved during the first 3 months of pregnancy. In contrast, we describe a clear increase in exposure after pregnancy among pre-delivery treatment-naïve women.<h4>Conclusions</h4>In spite of uncertainty concerning antidepressants' safety during pregnancy we find a 16-fold increase in exposure rates between 1997 and 2010. The rates describe a sharp decrease in exposure during pregnancy that is probably caused by physicians' hesitation to prescribe antidepressants and women's fear of unwanted effects on the unborn child. More studies are needed to clarify the consequences of antidepressant discontinuation during pregnancy.
format	article
author	Espen Jimenez-Solem Jon Trærup Andersen Morten Petersen Kasper Broedbaek Nadia Lyhne Andersen Christian Torp-Pedersen Henrik Enghusen Poulsen
author_facet	Espen Jimenez-Solem Jon Trærup Andersen Morten Petersen Kasper Broedbaek Nadia Lyhne Andersen Christian Torp-Pedersen Henrik Enghusen Poulsen
author_sort	Espen Jimenez-Solem
title	Prevalence of antidepressant use during pregnancy in Denmark, a nation-wide cohort study.
title_short	Prevalence of antidepressant use during pregnancy in Denmark, a nation-wide cohort study.
title_full	Prevalence of antidepressant use during pregnancy in Denmark, a nation-wide cohort study.
title_fullStr	Prevalence of antidepressant use during pregnancy in Denmark, a nation-wide cohort study.
title_full_unstemmed	Prevalence of antidepressant use during pregnancy in Denmark, a nation-wide cohort study.
title_sort	prevalence of antidepressant use during pregnancy in denmark, a nation-wide cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/f4bfcdc76a214710ba69a7678e2a8959
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Prevalence of antidepressant use during pregnancy in Denmark, a nation-wide cohort study.

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