MOG-IgG- versus AQP4-IgG-Positive Optic Neuritis in Thailand: Clinical Characteristics and Long-Term Visual Outcomes Comparison

Chanomporn Narongkhananukul,1 Tanyatuth Padungkiatsagul,1 Panitha Jindahra,2 Chaiyos Khongkhatithum,3 Lunliya Thampratankul,3 Kavin Vanikieti1 1Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Department of Medicine, Faculty of Medicine R...

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Autores principales:	Narongkhananukul C, Padungkiatsagul T, Jindahra P, Khongkhatithum C, Thampratankul L, Vanikieti K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	optic neuritis myelin oligodendrocyte glycoprotein aquaporin-4 neuromyelitis optica spectrum disorder thai Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f4c0c17db8bf4f8586c202269372ac05
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spelling	oai:doaj.org-article:f4c0c17db8bf4f8586c202269372ac052021-12-02T11:21:38ZMOG-IgG- versus AQP4-IgG-Positive Optic Neuritis in Thailand: Clinical Characteristics and Long-Term Visual Outcomes Comparison1177-5483https://doaj.org/article/f4c0c17db8bf4f8586c202269372ac052020-11-01T00:00:00Zhttps://www.dovepress.com/mog-igg--versus-aqp4-igg-positive-optic-neuritis-in-thailand-clinical--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Chanomporn Narongkhananukul,1 Tanyatuth Padungkiatsagul,1 Panitha Jindahra,2 Chaiyos Khongkhatithum,3 Lunliya Thampratankul,3 Kavin Vanikieti1 1Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 3Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Kavin Vanikieti Email Vanikieti.kavin@gmail.comPurpose: To compare demographic data, clinical and radiological characteristics, treatment, and long-term visual outcomes between myelin oligodendrocyte glycoprotein autoantibody-positive optic neuritis (MOG-IgG + ON) and aquaporin-4 autoantibody-positive optic neuritis (AQP4-IgG + ON) in Thailand.Patients and Methods: We included individuals who were diagnosed with either MOG-IgG + ON or AQP4-IgG + ON over an 11-year period. Demographic data, clinical and radiological characteristics at ON presentation, treatment, and long-term visual outcomes were retrospectively collected.Results: There were 16 patients (28 eyes) and 43 patients (59 eyes) in the MOG-IgG + ON and AQP4-IgG + ON groups, respectively. AQP4-IgG + ON occurred predominantly in female patients whereas MOG-IgG + ON-affected female patients and male patients equally (p < 0.001). Prior or concurrent non-ON demyelinating events were more often observed at AQP4-IgG + ON onset (p < 0.001). At ON presentation, bilaterality and the presence of optic disc edema were predominantly found in the MOG-IgG + ON group (bilaterality: 80% vs 8%, MOG-IgG + ON vs AQP4-IgG + ON patients, respectively (p < 0.001); presence of optic disc edema: 92.3% vs 36.6%, MOG-IgG + ON- vs AQP4-IgG + ON-affected eyes, respectively (p < 0.001)). There was no statistically significant difference in age at ON onset, nadir visual acuity (VA), presence of pain, segmental enhancement, and total enhanced segments of the anterior visual pathways. At the last follow-up, immunosuppressive drugs were used more often in the AQP4-IgG + ON group (43.7% vs 74.4%, MOG-IgG + ON vs AQP4-IgG + ON, respectively; p < 0.027). Remarkably better final VA was achieved in MOG-IgG + ON-affected eyes (median: 0.0 vs 0.4 logMAR, MOG-IgG + ON- vs AQP4-IgG + ON-affected eyes, respectively; p < 0.001).Conclusion: Compared with AQP4-IgG + ON, MOG-IgG + ON tended to present with bilaterality and optic disc edema and demonstrated better visual outcomes.Keywords: optic neuritis, myelin oligodendrocyte glycoprotein, aquaporin-4, neuromyelitis optica spectrum disorder, ThaiNarongkhananukul CPadungkiatsagul TJindahra PKhongkhatithum CThampratankul LVanikieti KDove Medical Pressarticleoptic neuritismyelin oligodendrocyte glycoproteinaquaporin-4neuromyelitis optica spectrum disorderthaiOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 4079-4088 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	optic neuritis myelin oligodendrocyte glycoprotein aquaporin-4 neuromyelitis optica spectrum disorder thai Ophthalmology RE1-994
spellingShingle	optic neuritis myelin oligodendrocyte glycoprotein aquaporin-4 neuromyelitis optica spectrum disorder thai Ophthalmology RE1-994 Narongkhananukul C Padungkiatsagul T Jindahra P Khongkhatithum C Thampratankul L Vanikieti K MOG-IgG- versus AQP4-IgG-Positive Optic Neuritis in Thailand: Clinical Characteristics and Long-Term Visual Outcomes Comparison
description	Chanomporn Narongkhananukul,1 Tanyatuth Padungkiatsagul,1 Panitha Jindahra,2 Chaiyos Khongkhatithum,3 Lunliya Thampratankul,3 Kavin Vanikieti1 1Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 3Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Kavin Vanikieti Email Vanikieti.kavin@gmail.comPurpose: To compare demographic data, clinical and radiological characteristics, treatment, and long-term visual outcomes between myelin oligodendrocyte glycoprotein autoantibody-positive optic neuritis (MOG-IgG + ON) and aquaporin-4 autoantibody-positive optic neuritis (AQP4-IgG + ON) in Thailand.Patients and Methods: We included individuals who were diagnosed with either MOG-IgG + ON or AQP4-IgG + ON over an 11-year period. Demographic data, clinical and radiological characteristics at ON presentation, treatment, and long-term visual outcomes were retrospectively collected.Results: There were 16 patients (28 eyes) and 43 patients (59 eyes) in the MOG-IgG + ON and AQP4-IgG + ON groups, respectively. AQP4-IgG + ON occurred predominantly in female patients whereas MOG-IgG + ON-affected female patients and male patients equally (p < 0.001). Prior or concurrent non-ON demyelinating events were more often observed at AQP4-IgG + ON onset (p < 0.001). At ON presentation, bilaterality and the presence of optic disc edema were predominantly found in the MOG-IgG + ON group (bilaterality: 80% vs 8%, MOG-IgG + ON vs AQP4-IgG + ON patients, respectively (p < 0.001); presence of optic disc edema: 92.3% vs 36.6%, MOG-IgG + ON- vs AQP4-IgG + ON-affected eyes, respectively (p < 0.001)). There was no statistically significant difference in age at ON onset, nadir visual acuity (VA), presence of pain, segmental enhancement, and total enhanced segments of the anterior visual pathways. At the last follow-up, immunosuppressive drugs were used more often in the AQP4-IgG + ON group (43.7% vs 74.4%, MOG-IgG + ON vs AQP4-IgG + ON, respectively; p < 0.027). Remarkably better final VA was achieved in MOG-IgG + ON-affected eyes (median: 0.0 vs 0.4 logMAR, MOG-IgG + ON- vs AQP4-IgG + ON-affected eyes, respectively; p < 0.001).Conclusion: Compared with AQP4-IgG + ON, MOG-IgG + ON tended to present with bilaterality and optic disc edema and demonstrated better visual outcomes.Keywords: optic neuritis, myelin oligodendrocyte glycoprotein, aquaporin-4, neuromyelitis optica spectrum disorder, Thai
format	article
author	Narongkhananukul C Padungkiatsagul T Jindahra P Khongkhatithum C Thampratankul L Vanikieti K
author_facet	Narongkhananukul C Padungkiatsagul T Jindahra P Khongkhatithum C Thampratankul L Vanikieti K
author_sort	Narongkhananukul C
title	MOG-IgG- versus AQP4-IgG-Positive Optic Neuritis in Thailand: Clinical Characteristics and Long-Term Visual Outcomes Comparison
title_short	MOG-IgG- versus AQP4-IgG-Positive Optic Neuritis in Thailand: Clinical Characteristics and Long-Term Visual Outcomes Comparison
title_full	MOG-IgG- versus AQP4-IgG-Positive Optic Neuritis in Thailand: Clinical Characteristics and Long-Term Visual Outcomes Comparison
title_fullStr	MOG-IgG- versus AQP4-IgG-Positive Optic Neuritis in Thailand: Clinical Characteristics and Long-Term Visual Outcomes Comparison
title_full_unstemmed	MOG-IgG- versus AQP4-IgG-Positive Optic Neuritis in Thailand: Clinical Characteristics and Long-Term Visual Outcomes Comparison
title_sort	mog-igg- versus aqp4-igg-positive optic neuritis in thailand: clinical characteristics and long-term visual outcomes comparison
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/f4c0c17db8bf4f8586c202269372ac05
work_keys_str_mv	AT narongkhananukulc mogiggversusaqp4iggpositiveopticneuritisinthailandclinicalcharacteristicsandlongtermvisualoutcomescomparison AT padungkiatsagult mogiggversusaqp4iggpositiveopticneuritisinthailandclinicalcharacteristicsandlongtermvisualoutcomescomparison AT jindahrap mogiggversusaqp4iggpositiveopticneuritisinthailandclinicalcharacteristicsandlongtermvisualoutcomescomparison AT khongkhatithumc mogiggversusaqp4iggpositiveopticneuritisinthailandclinicalcharacteristicsandlongtermvisualoutcomescomparison AT thampratankull mogiggversusaqp4iggpositiveopticneuritisinthailandclinicalcharacteristicsandlongtermvisualoutcomescomparison AT vanikietik mogiggversusaqp4iggpositiveopticneuritisinthailandclinicalcharacteristicsandlongtermvisualoutcomescomparison
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MOG-IgG- versus AQP4-IgG-Positive Optic Neuritis in Thailand: Clinical Characteristics and Long-Term Visual Outcomes Comparison

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