A 10-year review of underlying diseases for endothelial keratoplasty (DSAEK/DMEK) in a tertiary referral hospital in Japan

Tsubasa Nishino, Akira Kobayashi, Hideaki Yokogawa, Natsuko Mori, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Purpose: To report a 10-year review of endothelial keratoplasty (EK) procedures, Descemet&r...

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Autores principales:	Nishino T, Kobayashi A, Yokogawa H, Mori N, Masaki T, Sugiyama K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Descemet’s stripping automated endothelial keratoplasty Descemet’s membrane endothelial keratoplasty argon laser iridotomy. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f4c40f14babf4f4eb0ab50467802a13f
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spelling	oai:doaj.org-article:f4c40f14babf4f4eb0ab50467802a13f2021-12-02T02:24:17ZA 10-year review of underlying diseases for endothelial keratoplasty (DSAEK/DMEK) in a tertiary referral hospital in Japan1177-5483https://doaj.org/article/f4c40f14babf4f4eb0ab50467802a13f2018-08-01T00:00:00Zhttps://www.dovepress.com/a-10-year-review-of-underlying-diseases-for-endothelial-keratoplasty-d-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Tsubasa Nishino, Akira Kobayashi, Hideaki Yokogawa, Natsuko Mori, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Purpose: To report a 10-year review of endothelial keratoplasty (EK) procedures, Descemet’s stripping automated endothelial keratoplasty (DSAEK) and Descemet’s membrane endothelial keratoplasty (DMEK), and underlying diseases at a tertiary referral hospital in Japan. Study design: A single-center, retrospective case series. Methods: We retrospectively reviewed all medical records of bullous keratopathy (BK) surgically treated by EK (DSAEK/DMEK) at Kanazawa University Hospital from January 2007 to December 2016. Changes or modifications to the annual number of EK procedures and underlying diseases were analyzed. Results: During this period, 320 EK procedures (DSAEK: 288 cases, DMEK: 32 cases) were performed on 250 patients. Total annual EKs gradually increased from 19 to 45 cases between 2007 and 2016. The annual number of DSAEKs was stable, although the proportion of DSAEKs to other procedures decreased significantly as re-DSAEKs and DMEKs increased. BK after argon laser iridotomy (ALI) was the leading cause in 2007, followed by Fuchs’ endothelial dystrophy (FED) and failed penetrating keratoplasty. In 2016, BK after trabeculectomy (TLE) was most prevalent, followed by failed DSAEK, failed penetrating keratoplasty, and pseudophakic BK. The decreased ALI and FED, and increased BK after TLE and failed DSAEK were statistically significant. Conclusion: The distribution of EK procedures (DSAEK/DMEK) and underlying diseases changed over 10 years at a tertiary referral hospital in Japan. The proportion of re-DSAEK and DMEK increased among all EK procedures. Most significantly, among the underlying diseases, decreased ALI and FED and increased TLE and failed DSAEK were observed. Extended multicenter analysis may further elucidate the changes in EK procedures and the causes of BK in Japan. Keywords: argon laser iridotomy, trabeculectomy, reoperation, Fuchs’ endothelial dystrophyNishino TKobayashi AYokogawa HMori NMasaki TSugiyama KDove Medical PressarticleDescemet’s stripping automated endothelial keratoplastyDescemet’s membrane endothelial keratoplastyargon laser iridotomy.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 1359-1365 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Descemet’s stripping automated endothelial keratoplasty Descemet’s membrane endothelial keratoplasty argon laser iridotomy. Ophthalmology RE1-994
spellingShingle	Descemet’s stripping automated endothelial keratoplasty Descemet’s membrane endothelial keratoplasty argon laser iridotomy. Ophthalmology RE1-994 Nishino T Kobayashi A Yokogawa H Mori N Masaki T Sugiyama K A 10-year review of underlying diseases for endothelial keratoplasty (DSAEK/DMEK) in a tertiary referral hospital in Japan
description	Tsubasa Nishino, Akira Kobayashi, Hideaki Yokogawa, Natsuko Mori, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Purpose: To report a 10-year review of endothelial keratoplasty (EK) procedures, Descemet’s stripping automated endothelial keratoplasty (DSAEK) and Descemet’s membrane endothelial keratoplasty (DMEK), and underlying diseases at a tertiary referral hospital in Japan. Study design: A single-center, retrospective case series. Methods: We retrospectively reviewed all medical records of bullous keratopathy (BK) surgically treated by EK (DSAEK/DMEK) at Kanazawa University Hospital from January 2007 to December 2016. Changes or modifications to the annual number of EK procedures and underlying diseases were analyzed. Results: During this period, 320 EK procedures (DSAEK: 288 cases, DMEK: 32 cases) were performed on 250 patients. Total annual EKs gradually increased from 19 to 45 cases between 2007 and 2016. The annual number of DSAEKs was stable, although the proportion of DSAEKs to other procedures decreased significantly as re-DSAEKs and DMEKs increased. BK after argon laser iridotomy (ALI) was the leading cause in 2007, followed by Fuchs’ endothelial dystrophy (FED) and failed penetrating keratoplasty. In 2016, BK after trabeculectomy (TLE) was most prevalent, followed by failed DSAEK, failed penetrating keratoplasty, and pseudophakic BK. The decreased ALI and FED, and increased BK after TLE and failed DSAEK were statistically significant. Conclusion: The distribution of EK procedures (DSAEK/DMEK) and underlying diseases changed over 10 years at a tertiary referral hospital in Japan. The proportion of re-DSAEK and DMEK increased among all EK procedures. Most significantly, among the underlying diseases, decreased ALI and FED and increased TLE and failed DSAEK were observed. Extended multicenter analysis may further elucidate the changes in EK procedures and the causes of BK in Japan. Keywords: argon laser iridotomy, trabeculectomy, reoperation, Fuchs’ endothelial dystrophy
format	article
author	Nishino T Kobayashi A Yokogawa H Mori N Masaki T Sugiyama K
author_facet	Nishino T Kobayashi A Yokogawa H Mori N Masaki T Sugiyama K
author_sort	Nishino T
title	A 10-year review of underlying diseases for endothelial keratoplasty (DSAEK/DMEK) in a tertiary referral hospital in Japan
title_short	A 10-year review of underlying diseases for endothelial keratoplasty (DSAEK/DMEK) in a tertiary referral hospital in Japan
title_full	A 10-year review of underlying diseases for endothelial keratoplasty (DSAEK/DMEK) in a tertiary referral hospital in Japan
title_fullStr	A 10-year review of underlying diseases for endothelial keratoplasty (DSAEK/DMEK) in a tertiary referral hospital in Japan
title_full_unstemmed	A 10-year review of underlying diseases for endothelial keratoplasty (DSAEK/DMEK) in a tertiary referral hospital in Japan
title_sort	10-year review of underlying diseases for endothelial keratoplasty (dsaek/dmek) in a tertiary referral hospital in japan
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/f4c40f14babf4f4eb0ab50467802a13f
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A 10-year review of underlying diseases for endothelial keratoplasty (DSAEK/DMEK) in a tertiary referral hospital in Japan

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