The influence of physiological aging and atrophy on brain viscoelastic properties in humans.

Physiological aging of the brain is accompanied by ubiquitous degeneration of neurons and oligodendrocytes. An alteration of the cellular matrix of an organ impacts its macroscopic viscoelastic properties which can be detected by magnetic resonance elastography (MRE)--to date the only method for mea...

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Autores principales:	Ingolf Sack, Kaspar-Josche Streitberger, Dagmar Krefting, Friedemann Paul, Jürgen Braun
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f4c71fe2df464da4b08769913bd38257
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spelling	oai:doaj.org-article:f4c71fe2df464da4b08769913bd382572021-11-04T06:08:51ZThe influence of physiological aging and atrophy on brain viscoelastic properties in humans.1932-620310.1371/journal.pone.0023451https://doaj.org/article/f4c71fe2df464da4b08769913bd382572011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21931599/?tool=EBIhttps://doaj.org/toc/1932-6203Physiological aging of the brain is accompanied by ubiquitous degeneration of neurons and oligodendrocytes. An alteration of the cellular matrix of an organ impacts its macroscopic viscoelastic properties which can be detected by magnetic resonance elastography (MRE)--to date the only method for measuring brain mechanical parameters without intervention. However, the wave patterns detected by MRE are affected by atrophic changes in brain geometry occurring in an individual's life span. Moreover, regional variability in MRE-detected age effects is expected corresponding to the regional variation in atrophy. Therefore, the sensitivity of brain MRE to brain volume and aging was investigated in 66 healthy volunteers aged 18-72. A linear decline in whole-brain elasticity was observed (-0.75%/year, R-square = 0.59, p<0.001); the rate is three times that determined by volume measurements (-0.23%/year, R-square = 0.4, p<0.001). The highest decline in elasticity (-0.92%/year, R-square = 0.43, p<0.001) was observed in a region of interest placed in the frontal lobe with minimal age-related shrinkage (-0.1%, R-square = 0.06, p = 0.043). Our results suggest that cerebral MRE can measure geometry-independent viscoelastic parameters related to intrinsic tissue structure and altered by age.Ingolf SackKaspar-Josche StreitbergerDagmar KreftingFriedemann PaulJürgen BraunPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e23451 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ingolf Sack Kaspar-Josche Streitberger Dagmar Krefting Friedemann Paul Jürgen Braun The influence of physiological aging and atrophy on brain viscoelastic properties in humans.
description	Physiological aging of the brain is accompanied by ubiquitous degeneration of neurons and oligodendrocytes. An alteration of the cellular matrix of an organ impacts its macroscopic viscoelastic properties which can be detected by magnetic resonance elastography (MRE)--to date the only method for measuring brain mechanical parameters without intervention. However, the wave patterns detected by MRE are affected by atrophic changes in brain geometry occurring in an individual's life span. Moreover, regional variability in MRE-detected age effects is expected corresponding to the regional variation in atrophy. Therefore, the sensitivity of brain MRE to brain volume and aging was investigated in 66 healthy volunteers aged 18-72. A linear decline in whole-brain elasticity was observed (-0.75%/year, R-square = 0.59, p<0.001); the rate is three times that determined by volume measurements (-0.23%/year, R-square = 0.4, p<0.001). The highest decline in elasticity (-0.92%/year, R-square = 0.43, p<0.001) was observed in a region of interest placed in the frontal lobe with minimal age-related shrinkage (-0.1%, R-square = 0.06, p = 0.043). Our results suggest that cerebral MRE can measure geometry-independent viscoelastic parameters related to intrinsic tissue structure and altered by age.
format	article
author	Ingolf Sack Kaspar-Josche Streitberger Dagmar Krefting Friedemann Paul Jürgen Braun
author_facet	Ingolf Sack Kaspar-Josche Streitberger Dagmar Krefting Friedemann Paul Jürgen Braun
author_sort	Ingolf Sack
title	The influence of physiological aging and atrophy on brain viscoelastic properties in humans.
title_short	The influence of physiological aging and atrophy on brain viscoelastic properties in humans.
title_full	The influence of physiological aging and atrophy on brain viscoelastic properties in humans.
title_fullStr	The influence of physiological aging and atrophy on brain viscoelastic properties in humans.
title_full_unstemmed	The influence of physiological aging and atrophy on brain viscoelastic properties in humans.
title_sort	influence of physiological aging and atrophy on brain viscoelastic properties in humans.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/f4c71fe2df464da4b08769913bd38257
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The influence of physiological aging and atrophy on brain viscoelastic properties in humans.

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