Micronucleus frequency in buccal mucosa cells of patients with neurodegenerative diseases

Abstract Neurodegenerative diseases show an increase in prevalence and incidence, with the most prominent example being Alzheimer’s disease. DNA damage has been suggested to play a role in the pathogenesis, but the exact mechanisms remain elusive. We enrolled 425 participants with and without neurod...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hauke Reimann, Helga Stopper, Thomas Polak, Martin Lauer, Martin J. Herrmann, Jürgen Deckert, Henning Hintzsche
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f4c811eeba6f4a1fa6a438b33687128e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f4c811eeba6f4a1fa6a438b33687128e
record_format	dspace
spelling	oai:doaj.org-article:f4c811eeba6f4a1fa6a438b33687128e2021-12-02T13:58:12ZMicronucleus frequency in buccal mucosa cells of patients with neurodegenerative diseases10.1038/s41598-020-78832-y2045-2322https://doaj.org/article/f4c811eeba6f4a1fa6a438b33687128e2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78832-yhttps://doaj.org/toc/2045-2322Abstract Neurodegenerative diseases show an increase in prevalence and incidence, with the most prominent example being Alzheimer’s disease. DNA damage has been suggested to play a role in the pathogenesis, but the exact mechanisms remain elusive. We enrolled 425 participants with and without neurodegenerative diseases and analyzed DNA damage in the form of micronuclei in buccal mucosa samples. In addition, other parameters such as binucleated cells, karyolytic cells, and karyorrhectic cells were quantified. No relevant differences in DNA damage and cytotoxicity markers were observed in patients compared to healthy participants. Furthermore, other parameters such as lifestyle factors and diseases were also investigated. Overall, this study could not identify a direct link between changes in buccal cells and neurogenerative diseases, but highlights the influence of lifestyle factors and diseases on the human buccal cytome.Hauke ReimannHelga StopperThomas PolakMartin LauerMartin J. HerrmannJürgen DeckertHenning HintzscheNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hauke Reimann Helga Stopper Thomas Polak Martin Lauer Martin J. Herrmann Jürgen Deckert Henning Hintzsche Micronucleus frequency in buccal mucosa cells of patients with neurodegenerative diseases
description	Abstract Neurodegenerative diseases show an increase in prevalence and incidence, with the most prominent example being Alzheimer’s disease. DNA damage has been suggested to play a role in the pathogenesis, but the exact mechanisms remain elusive. We enrolled 425 participants with and without neurodegenerative diseases and analyzed DNA damage in the form of micronuclei in buccal mucosa samples. In addition, other parameters such as binucleated cells, karyolytic cells, and karyorrhectic cells were quantified. No relevant differences in DNA damage and cytotoxicity markers were observed in patients compared to healthy participants. Furthermore, other parameters such as lifestyle factors and diseases were also investigated. Overall, this study could not identify a direct link between changes in buccal cells and neurogenerative diseases, but highlights the influence of lifestyle factors and diseases on the human buccal cytome.
format	article
author	Hauke Reimann Helga Stopper Thomas Polak Martin Lauer Martin J. Herrmann Jürgen Deckert Henning Hintzsche
author_facet	Hauke Reimann Helga Stopper Thomas Polak Martin Lauer Martin J. Herrmann Jürgen Deckert Henning Hintzsche
author_sort	Hauke Reimann
title	Micronucleus frequency in buccal mucosa cells of patients with neurodegenerative diseases
title_short	Micronucleus frequency in buccal mucosa cells of patients with neurodegenerative diseases
title_full	Micronucleus frequency in buccal mucosa cells of patients with neurodegenerative diseases
title_fullStr	Micronucleus frequency in buccal mucosa cells of patients with neurodegenerative diseases
title_full_unstemmed	Micronucleus frequency in buccal mucosa cells of patients with neurodegenerative diseases
title_sort	micronucleus frequency in buccal mucosa cells of patients with neurodegenerative diseases
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f4c811eeba6f4a1fa6a438b33687128e
work_keys_str_mv	AT haukereimann micronucleusfrequencyinbuccalmucosacellsofpatientswithneurodegenerativediseases AT helgastopper micronucleusfrequencyinbuccalmucosacellsofpatientswithneurodegenerativediseases AT thomaspolak micronucleusfrequencyinbuccalmucosacellsofpatientswithneurodegenerativediseases AT martinlauer micronucleusfrequencyinbuccalmucosacellsofpatientswithneurodegenerativediseases AT martinjherrmann micronucleusfrequencyinbuccalmucosacellsofpatientswithneurodegenerativediseases AT jurgendeckert micronucleusfrequencyinbuccalmucosacellsofpatientswithneurodegenerativediseases AT henninghintzsche micronucleusfrequencyinbuccalmucosacellsofpatientswithneurodegenerativediseases
_version_	1718392237114523648

Micronucleus frequency in buccal mucosa cells of patients with neurodegenerative diseases

Ejemplares similares