Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma

Glioblastoma patients are treated with Aurora kinase A (AURKA) inhibitors but resistance can occur. Here, the authors show that AURKA inhibition induces metabolic reprogramming, which leads to increased mitochondrial activity and inhibition of oxidative metabolism sensitizes glioblastoma cells to AU...

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Autores principales:	Trang T. T. Nguyen, Enyuan Shang, Chang Shu, Sungsoo Kim, Angeliki Mela, Nelson Humala, Aayushi Mahajan, Hee Won Yang, Hasan Orhan Akman, Catarina M. Quinzii, Guoan Zhang, Mike-Andrew Westhoff, Georg Karpel-Massler, Jeffrey N. Bruce, Peter Canoll, Markus D. Siegelin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f4ce109d7c6840f1a279ca28a9499ce7
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spelling	oai:doaj.org-article:f4ce109d7c6840f1a279ca28a9499ce72021-12-02T19:04:19ZAurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma10.1038/s41467-021-25501-x2041-1723https://doaj.org/article/f4ce109d7c6840f1a279ca28a9499ce72021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25501-xhttps://doaj.org/toc/2041-1723Glioblastoma patients are treated with Aurora kinase A (AURKA) inhibitors but resistance can occur. Here, the authors show that AURKA inhibition induces metabolic reprogramming, which leads to increased mitochondrial activity and inhibition of oxidative metabolism sensitizes glioblastoma cells to AURKA inhibition.Trang T. T. NguyenEnyuan ShangChang ShuSungsoo KimAngeliki MelaNelson HumalaAayushi MahajanHee Won YangHasan Orhan AkmanCatarina M. QuinziiGuoan ZhangMike-Andrew WesthoffGeorg Karpel-MasslerJeffrey N. BrucePeter CanollMarkus D. SiegelinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Trang T. T. Nguyen Enyuan Shang Chang Shu Sungsoo Kim Angeliki Mela Nelson Humala Aayushi Mahajan Hee Won Yang Hasan Orhan Akman Catarina M. Quinzii Guoan Zhang Mike-Andrew Westhoff Georg Karpel-Massler Jeffrey N. Bruce Peter Canoll Markus D. Siegelin Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma
description	Glioblastoma patients are treated with Aurora kinase A (AURKA) inhibitors but resistance can occur. Here, the authors show that AURKA inhibition induces metabolic reprogramming, which leads to increased mitochondrial activity and inhibition of oxidative metabolism sensitizes glioblastoma cells to AURKA inhibition.
format	article
author	Trang T. T. Nguyen Enyuan Shang Chang Shu Sungsoo Kim Angeliki Mela Nelson Humala Aayushi Mahajan Hee Won Yang Hasan Orhan Akman Catarina M. Quinzii Guoan Zhang Mike-Andrew Westhoff Georg Karpel-Massler Jeffrey N. Bruce Peter Canoll Markus D. Siegelin
author_facet	Trang T. T. Nguyen Enyuan Shang Chang Shu Sungsoo Kim Angeliki Mela Nelson Humala Aayushi Mahajan Hee Won Yang Hasan Orhan Akman Catarina M. Quinzii Guoan Zhang Mike-Andrew Westhoff Georg Karpel-Massler Jeffrey N. Bruce Peter Canoll Markus D. Siegelin
author_sort	Trang T. T. Nguyen
title	Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma
title_short	Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma
title_full	Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma
title_fullStr	Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma
title_full_unstemmed	Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma
title_sort	aurora kinase a inhibition reverses the warburg effect and elicits unique metabolic vulnerabilities in glioblastoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f4ce109d7c6840f1a279ca28a9499ce7
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Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma

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